4EF9

Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate

Summary for 4EF9

Entry DOI	10.2210/pdb4ef9/pdb
Related	4EF8
Descriptor	Dihydroorotate dehydrogenase, N-(4-nitrophenyl)thioformamide, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
Functional Keywords	leishmania major, dihydroorotate dehydrogenase, 4-nitrophenyl isothiocyanate, pyrd, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Leishmania major
Total number of polymer chains	2
Total formula weight	78452.77
Authors	Pinheiro, M.P.,Emery, F.S.,Nonato, M.C. (deposition date: 2012-03-29, release date: 2012-12-12, Last modification date: 2023-09-13)
Primary citation	Pinheiro, M.P.,Emery, F.S.,Nonato, M.C. Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19:2615-2627, 2013 Cited by PubMed: 23116399 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation