8FIL
| Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate | Descriptor: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | Deposit date: | 2022-12-16 | Release date: | 2023-09-06 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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8FIK
| APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate | Descriptor: | CHLORIDE ION, DNA (5'-D(P*CP*CP*CP*AP*TP*CP*AP*TP*TP*CP*GP*AP*TP*GP*GP*G)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | Deposit date: | 2022-12-16 | Release date: | 2023-09-06 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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8FII
| Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 1) | Descriptor: | DNA (5'-D(P*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*C)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ... | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | Deposit date: | 2022-12-16 | Release date: | 2023-09-06 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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8FIJ
| Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 2) | Descriptor: | DNA (5'-D(*GP*CP*GP*CP*TP*TP*(UFP)P*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, PHOSPHATE ION, ... | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | Deposit date: | 2022-12-16 | Release date: | 2023-09-06 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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8FIM
| Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate | Descriptor: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*GP*CP*TP*TP*CP*GP*CP*GP*CP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3A, ... | Authors: | Harjes, S, Jameson, G.B, Harjes, E, Filichev, V.V, Kurup, H.M. | Deposit date: | 2022-12-16 | Release date: | 2023-09-06 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nat Commun, 14, 2023
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8H0I
| Cryo-EM structure of APOBEC3G-Vif complex | Descriptor: | APOBEC3G, CHLORIDE ION, Core binding factor beta, ... | Authors: | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | Deposit date: | 2022-09-29 | Release date: | 2023-07-19 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G. Nat Commun, 14, 2023
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8J62
| Cryo-EM structure of APOBEC3G-Vif complex | Descriptor: | APOBEC3G, Core binding factor beta, RNA (5'-R(*CP*GP*GP*UP*UP*GP*AP*UP*UP*GP*UP*UP*UP*UP*AP*AP*CP*AP*A)-3'), ... | Authors: | Kouno, T, Shibata, S, Hyun, J, Kim, T.G, Wolf, M. | Deposit date: | 2023-04-24 | Release date: | 2023-07-19 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G. Nat Commun, 14, 2023
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8CX2
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX0
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX1
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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7UXD
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7RW6
| BORF2-APOBEC3Bctd Complex | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION | Authors: | Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S. | Deposit date: | 2021-08-19 | Release date: | 2022-04-27 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. Sci Adv, 8, 2022
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7D3V
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7D3X
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7D3W
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6X91
| Crystal structure of MBP-fused human APOBEC1 | Descriptor: | CACODYLATE ION, Maltodextrin-binding protein, C->U-editing enzyme APOBEC-1 chimera, ... | Authors: | Wolfe, A.D, Li, S.-X, Chen, X.S. | Deposit date: | 2020-06-02 | Release date: | 2020-12-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.51 Å) | Cite: | The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. NAR Cancer, 2, 2020
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6NFK
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G bound to iodide | Descriptor: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IODIDE ION | Authors: | Shi, K, Orellana, K, Aihara, H. | Deposit date: | 2018-12-20 | Release date: | 2019-12-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B Faseb Bioadv, 2, 2020
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6NFM
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6NFL
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B with loop 7 from APOBEC3G complexed with 2-HP | Descriptor: | 1,2-ETHANEDIOL, 1,3-diazinan-2-one, CHLORIDE ION, ... | Authors: | Shi, K, Orellana, K, Aihara, H. | Deposit date: | 2018-12-20 | Release date: | 2019-12-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.731 Å) | Cite: | Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B Faseb Bioadv, 2, 2020
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6K3K
| Solution structure of APOBEC3G-CD2 with ssDNA, Product B | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, DNA/RNA (5'-D(*AP*TP*TP*CP*UP*(ICY)P*AP*AP*TP*T)-3'), ZINC ION | Authors: | Cao, C, Yan, X, Lan, W, Wang, C. | Deposit date: | 2019-05-19 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. Chem Asian J, 14, 2019
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6K3J
| Solution structure of APOBEC3G-CD2 with ssDNA, Product A | Descriptor: | DNA (5'-D(*AP*TP*TP*CP*UP*(IUR)P*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Cao, C, Yan, X, Lan, W, Wang, C. | Deposit date: | 2019-05-19 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. Chem Asian J, 14, 2019
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6BUX
| CRYSTAL STRUCTURE OF APOBEC3G CATALYTIC DOMAIN COMPLEX WITH SUBSTRATE SSDNA | Descriptor: | Apolipoprotein B mRNA editing enzyme catalytic subunit 3G catalytic domain, DNA (5'-D(*AP*AP*TP*CP*CP*CP*AP*AP*A)-3'), GLYCEROL, ... | Authors: | Maiti, A, Matsuo, H. | Deposit date: | 2017-12-11 | Release date: | 2018-07-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.856 Å) | Cite: | Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA. Nat Commun, 9, 2018
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6BWY
| DNA substrate selection by APOBEC3G | Descriptor: | DNA (30-MER), PHOSPHATE ION, Protection of telomeres protein 1, ... | Authors: | Ziegler, S.J, Buzovetsky, O. | Deposit date: | 2017-12-15 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. PLoS ONE, 13, 2018
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5SXG
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | Descriptor: | 1,3-PROPANDIOL, DNA dC->dU-editing enzyme APOBEC-3B, IMIDAZOLE, ... | Authors: | Shi, K, Kurahashi, K, Aihara, H. | Deposit date: | 2016-08-09 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Sci Rep, 7, 2017
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5SXH
| Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B | Descriptor: | 1,2-ETHANEDIOL, DNA dC->dU-editing enzyme APOBEC-3B, ZINC ION | Authors: | Shi, K, Kurahashi, K, Aihara, H. | Deposit date: | 2016-08-09 | Release date: | 2017-12-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Sci Rep, 7, 2017
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