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2KSR
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BU of 2ksr by Molmil
NMR structures of TM domain of the n-Acetylcholine receptor b2 subunit
Descriptor: Neuronal acetylcholine receptor subunit beta-2
Authors:Bondarenko, V, Tillman, T, Xu, Y, Tang, P.
Deposit date:2010-01-12
Release date:2010-06-16
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit.
Biochim.Biophys.Acta, 1798, 2010
1OED
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BU of 1oed by Molmil
STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES
Descriptor: Acetylcholine receptor beta subunit, Acetylcholine receptor delta subunit, Acetylcholine receptor gamma subunit, ...
Authors:Miyazawa, A, Fujiyoshi, Y, Unwin, N.
Deposit date:2003-03-24
Release date:2003-06-26
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure and Gating Mechanism of the Acetylcholine Receptor Pore.
Nature, 423, 2003
1VRY
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BU of 1vry by Molmil
Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor
Descriptor: Glycine receptor alpha-1 chain
Authors:Ma, D, Liu, Z, Li, L, Tang, P, Xu, Y.
Deposit date:2005-07-20
Release date:2005-07-26
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Second and Third Transmembrane Domains of Human Glycine Receptor.
Biochemistry, 44, 2005
2LM2
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BU of 2lm2 by Molmil
NMR structures of the transmembrane domains of the AChR b2 subunit
Descriptor: Neuronal acetylcholine receptor subunit beta-2
Authors:Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P.
Deposit date:2011-11-18
Release date:2012-03-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NMR structures of the transmembrane domains of the a4b2 nAChR.
Biochim.Biophys.Acta, 1818, 2012
2MAW
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BU of 2maw by Molmil
NMR structures of the alpha7 nAChR transmembrane domain.
Descriptor: Neuronal acetylcholine receptor subunit alpha-7
Authors:Bondarenko, V, Mowrey, D, Xu, Y, Tang, P.
Deposit date:2013-07-19
Release date:2013-11-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Insights into distinct modulation of alpha 7 and alpha 7 beta 2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane.
J.Biol.Chem., 288, 2013
2M6I
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BU of 2m6i by Molmil
Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit
Descriptor: Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit
Authors:Mowrey, D, Cui, T, Jia, Y, Ma, D, Makhov, A.M, Zhang, P, Tang, P, Xu, Y.
Deposit date:2013-03-29
Release date:2013-09-04
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Open-Channel Structures of the Human Glycine Receptor alpha 1 Full-Length Transmembrane Domain.
Structure, 21, 2013
2M6B
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BU of 2m6b by Molmil
Structure of full-length transmembrane domains of human glycine receptor alpha1 monomer subunit
Descriptor: Full-Length Transmembrane Domains of Human Glycine Receptor alpha1 Subunit
Authors:Mowrey, D, Cui, T, Jia, Y, Ma, D, Makhov, A.M, Zhang, P, Tang, P, Xu, Y.
Deposit date:2013-03-28
Release date:2013-09-04
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Open-Channel Structures of the Human Glycine Receptor alpha 1 Full-Length Transmembrane Domain.
Structure, 21, 2013
2LLY
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BU of 2lly by Molmil
NMR structures of the transmembrane domains of the nAChR a4 subunit
Descriptor: Neuronal acetylcholine receptor subunit alpha-4
Authors:Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P.
Deposit date:2011-11-18
Release date:2012-03-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NMR structures of the transmembrane domains of the a4b2 nAChR.
Biochim.Biophys.Acta, 1818, 2012
7RPM
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BU of 7rpm by Molmil
Structures of the Intracellular Domain and Transmembrane Domain of the Human alpha7 Nicotinic Acetylcholine Receptors
Descriptor: Neuronal acetylcholine receptor subunit alpha-7
Authors:Bondarenko, V, Chen, Q, Tang, P.
Deposit date:2021-08-03
Release date:2022-01-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of highly flexible intracellular domain of human alpha 7 nicotinic acetylcholine receptor.
Nat Commun, 13, 2022
8F4V
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BU of 8f4v by Molmil
Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state
Descriptor: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Neuronal acetylcholine receptor subunit alpha-7
Authors:Bondarenko, V, Chen, Q, Tang, P.
Deposit date:2022-11-11
Release date:2023-02-22
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Elucidation of Ivermectin Binding to alpha 7nAChR and the Induced Channel Desensitization.
Acs Chem Neurosci, 14, 2023
4COF
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BU of 4cof by Molmil
Crystal structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, CHLORIDE ION, ...
Authors:Miller, P.S, Aricescu, A.R.
Deposit date:2014-01-28
Release date:2014-06-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Crystal Structure of a Human Gabaa Receptor
Nature, 512, 2014
6I53
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BU of 6i53 by Molmil
Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ...
Authors:Laverty, D, Desai, R, Uchanski, T, Masiulis, S, Wojciech, J.S, Malinauskas, T, Zivanov, J, Pardon, E, Steyaert, J, Miller, K.W, Aricescu, A.R.
Deposit date:2018-11-12
Release date:2019-01-02
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer.
Nature, 565, 2019
8QQM
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BU of 8qqm by Molmil
nicotinic acetylcholine receptor in intact synaptic membrane
Descriptor: Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, Acetylcholine receptor subunit delta, ...
Authors:Unwin, N.
Deposit date:2023-10-05
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor.
Proc.Natl.Acad.Sci.USA, 121, 2024
5CFB
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BU of 5cfb by Molmil
Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-3,Glycine receptor subunit alpha-3, ...
Authors:Shaffer, P.L, Huang, X, Chen, H.
Deposit date:2015-07-08
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Crystal structure of human glycine receptor-alpha 3 bound to antagonist strychnine.
Nature, 526, 2015
5KXI
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BU of 5kxi by Molmil
X-ray structure of the human Alpha4Beta2 nicotinic receptor
Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuronal acetylcholine receptor subunit alpha-4, ...
Authors:Morales-Perez, C.L, Noviello, C.M, Hibbs, R.E.
Deposit date:2016-07-20
Release date:2016-09-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.941 Å)
Cite:X-ray structure of the human alpha 4 beta 2 nicotinic receptor.
Nature, 538, 2016
7PBD
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BU of 7pbd by Molmil
a1b3 GABA-A receptor + GABA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Miller, P.S, Kasaragod, V.B.
Deposit date:2021-08-02
Release date:2022-02-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
4X5T
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BU of 4x5t by Molmil
alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC
Descriptor: ACETATE ION, CHLORIDE ION, NICKEL (II) ION, ...
Authors:Sauguet, L, Corringer, P.J, Huon, C, Delarue, M.
Deposit date:2014-12-05
Release date:2015-02-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Allosteric and hyperekplexic mutant phenotypes investigated on an alpha 1 glycine receptor transmembrane structure.
Proc.Natl.Acad.Sci.USA, 112, 2015
6NP0
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BU of 6np0 by Molmil
Cryo-EM structure of 5HT3A receptor in presence of granisetron
Descriptor: 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Basak, S, Chakrapani, S.
Deposit date:2019-01-17
Release date:2019-07-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor.
Nat Commun, 10, 2019
2BG9
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BU of 2bg9 by Molmil
REFINED STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTOR AT 4A RESOLUTION.
Descriptor: ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA CHAIN, BETA CHAIN, ...
Authors:Unwin, N.
Deposit date:2004-12-17
Release date:2005-02-16
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution
J.Mol.Biol., 346, 2005
4PIR
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BU of 4pir by Molmil
X-ray structure of the mouse serotonin 5-HT3 receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ...
Authors:Hassaine, G, Deluz, C, Grasso, L, Wyss, R, Tol, M.B, Hovius, R, Graff, A, Stahlberg, H, Tomizaki, T, Desmyter, A, Moreau, C, Li, X.-D, Poitevin, F, Vogel, H, Nury, H.
Deposit date:2014-05-09
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of the mouse serotonin 5-HT3 receptor.
Nature, 512, 2014
7Z14
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BU of 7z14 by Molmil
Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain neurotoxin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ...
Authors:Nys, M.A.E.M, Zarkadas, E, Ulens, C, Nury, H.
Deposit date:2022-02-24
Release date:2022-08-17
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:The molecular mechanism of snake short-chain alpha-neurotoxin binding to muscle-type nicotinic acetylcholine receptors.
Nat Commun, 13, 2022
5TIO
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BU of 5tio by Molmil
Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607
Descriptor: (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
Authors:Shaffer, P.L, Huang, X, Chen, H.
Deposit date:2016-10-03
Release date:2017-01-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain
To Be Published
6A96
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BU of 6a96 by Molmil
Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, ...
Authors:Liu, S, Xu, L, Guan, F, Liu, Y.T, Cui, Y, Zhang, Q, Bi, G.Q, Zhou, Z.H, Zhang, X, Ye, S.
Deposit date:2018-07-11
Release date:2018-10-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Cryo-EM structure of the human alpha 5 beta 3 GABAAreceptor.
Cell Res., 28, 2018
4TNW
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BU of 4tnw by Molmil
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ...
Authors:Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E.
Deposit date:2014-06-05
Release date:2014-08-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
Nature, 512, 2014
4TNV
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BU of 4tnv by Molmil
C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ...
Authors:Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E.
Deposit date:2014-06-05
Release date:2014-08-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
Nature, 512, 2014

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