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6P2U
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BU of 6p2u by Molmil
Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate
Descriptor: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Moseng, M.A, Page, R.C.
Deposit date:2019-05-22
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
Febs Lett., 593, 2019
1QQN
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BU of 1qqn by Molmil
D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ...
Authors:Johnson, E.R, McKay, D.B.
Deposit date:1999-06-07
Release date:1999-09-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein.
Biochemistry, 38, 1999
6NHK
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BU of 6nhk by Molmil
Mortalin nucleotide binding domain in the ADP-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Page, R.C, Moseng, M.A, Nix, J.C.
Deposit date:2018-12-23
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.777 Å)
Cite:Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
2KHO
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BU of 2kho by Molmil
NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate
Descriptor: Heat shock protein 70
Authors:Zuiderweg, E.R.P, Bertelsen, E.B.
Deposit date:2009-04-10
Release date:2009-05-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.
Proc.Natl.Acad.Sci.USA, 106, 2009
5FPE
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BU of 5fpe by Molmil
Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site.
Descriptor: 3-AMINO-1,2,4-TRIAZOLE, HEAT SHOCK-RELATED 70KDA PROTEIN 2
Authors:Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M.
Deposit date:2015-11-28
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Detection of Secondary Binding Sites in Proteins Using Fragment Screening.
Proc.Natl.Acad.Sci.USA, 112, 2015
5MKR
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BU of 5mkr by Molmil
HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation
Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A
Authors:Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M.
Deposit date:2016-12-05
Release date:2017-03-01
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Angew. Chem. Int. Ed. Engl., 56, 2017
5FPD
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BU of 5fpd by Molmil
Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site.
Descriptor: HEAT SHOCK-RELATED 70KDA PROTEIN 2, PYRAZINE-2-CARBOXAMIDE
Authors:Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M.
Deposit date:2015-11-28
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Detection of Secondary Binding Sites in Proteins Using Fragment Screening.
Proc.Natl.Acad.Sci.USA, 112, 2015
5MB9
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BU of 5mb9 by Molmil
Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I.
Deposit date:2016-11-07
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex.
Nat. Struct. Mol. Biol., 24, 2017
5GJJ
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BU of 5gjj by Molmil
Glutathionylated hHsp70 SBD
Descriptor: Heat shock 70 kDa protein 1A
Authors:Gong, W.B, Yang, J, Zhang, H, Perrett, S.
Deposit date:2016-06-30
Release date:2017-07-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of glutathionylated hHsp70 SBD (385-641)
To Be Published
1U00
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BU of 1u00 by Molmil
HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC
Descriptor: Chaperone protein hscA, IscU recognition peptide
Authors:Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E.
Deposit date:2004-07-12
Release date:2004-10-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC.
J.Mol.Biol., 342, 2004
1S3X
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BU of 1s3x by Molmil
The crystal structure of the human Hsp70 ATPase domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ...
Authors:Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A.
Deposit date:2004-01-14
Release date:2004-01-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
Structure, 5, 1997
5FPM
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BU of 5fpm by Molmil
Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site.
Descriptor: 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL, HEAT SHOCK-RELATED 70KDA PROTEIN 2
Authors:Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M.
Deposit date:2015-12-02
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Detection of Secondary Binding Sites in Proteins Using Fragment Screening.
Proc.Natl.Acad.Sci.USA, 112, 2015
5TKY
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BU of 5tky by Molmil
Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein
Authors:Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I.
Deposit date:2016-10-10
Release date:2016-11-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain.
Nat Commun, 7, 2016
4B9Q
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BU of 4b9q by Molmil
Open conformation of ATP-bound Hsp70 homolog DnaK
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION
Authors:Kopp, J, Mayer, M.P, Sinning, I.
Deposit date:2012-09-06
Release date:2012-11-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones
Mol.Cell, 48, 2012
6SR6
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BU of 6sr6 by Molmil
Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ...
Authors:Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I.
Deposit date:2019-09-05
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb.
Nat Commun, 11, 2020
5UMB
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BU of 5umb by Molmil
Crystal structure of ATPase domain of Malaria GRP78 with ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ...
Authors:Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H.
Deposit date:2017-01-26
Release date:2022-07-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Repurposing drugs to target the malaria parasite unfolding protein response.
Sci Rep, 8, 2018
1YUW
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BU of 1yuw by Molmil
crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Descriptor: Heat shock cognate 71 kDa protein
Authors:Jiang, J, Lafer, E.M, Prasad, K, Sousa, R.
Deposit date:2005-02-14
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of interdomain communication in the Hsc70 chaperone
Mol.Cell, 20, 2005
7Q4R
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BU of 7q4r by Molmil
Crystal structure of human HSP72-NBD in complex with fragment 1
Descriptor: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ...
Authors:Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M.
Deposit date:2021-11-02
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
Molecules, 27, 2022
6PMT
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BU of 6pmt by Molmil
Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate
Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ...
Authors:Moseng, M.A, Nix, J.C, Page, R.C.
Deposit date:2019-07-02
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate
to be published
7PLK
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BU of 7plk by Molmil
Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ...
Authors:Zehe, M, Grimm, C, Sotriffer, C.
Deposit date:2021-08-31
Release date:2022-09-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.48781371 Å)
Cite:Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
7RAX
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BU of 7rax by Molmil
ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2021-07-04
Release date:2023-07-05
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021
6S02
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BU of 6s02 by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION
Authors:Vakonakis, I, Day, J.
Deposit date:2019-06-13
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite.
Faseb J., 33, 2019
6RZQ
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BU of 6rzq by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state
Descriptor: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ...
Authors:Vakonakis, I, Day, J.
Deposit date:2019-06-13
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite.
Faseb J., 33, 2019
1DKZ
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BU of 1dkz by Molmil
THE SUBSTRATE BINDING DOMAIN OF DNAK IN COMPLEX WITH A SUBSTRATE PEPTIDE, DETERMINED FROM TYPE 1 NATIVE CRYSTALS
Descriptor: SUBSTRATE BINDING DOMAIN OF DNAK, SUBSTRATE PEPTIDE (7 RESIDUES)
Authors:Zhu, X, Zhao, X, Burkholder, W.F, Gragerov, A, Ogata, C.M, Gottesman, M.E, Hendrickson, W.A.
Deposit date:1996-06-03
Release date:1996-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of substrate binding by the molecular chaperone DnaK.
Science, 272, 1996
2BPR
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BU of 2bpr by Molmil
NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES
Descriptor: DNAK
Authors:Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P.
Deposit date:1998-08-11
Release date:1999-03-02
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction.
Biochemistry, 37, 1998

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