PDB: 278 resultsInfo pagesStatus searchChemie searchBIRD

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6NHK	Mortalin nucleotide binding domain in the ADP-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Page, R.C, Moseng, M.A, Nix, J.C. Deposit date: 2018-12-23 Release date: 2019-04-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.777 Å) Cite: Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
6ZHI	Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide Descriptor: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70 Authors: Schmidt, J, Vakonakis, I. Deposit date: 2020-06-23 Release date: 2020-09-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structure of the PfHsp70-x SBD Acta Crystallographica Section F
5GJJ	Glutathionylated hHsp70 SBD Descriptor: Heat shock 70 kDa protein 1A Authors: Gong, W.B, Yang, J, Zhang, H, Perrett, S. Deposit date: 2016-06-30 Release date: 2017-07-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
2E88	Crystal structure of the human Hsp70 ATPase domain in the apo form Descriptor: Heat shock 70kDa protein 1A, ZINC ION Authors: Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-01-19 Release date: 2008-01-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein Authors: Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. Deposit date: 2016-10-10 Release date: 2016-11-16 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
4R5K	Crystal structure of the DnaK C-terminus (Dnak-SBD-B) Descriptor: CALCIUM ION, Chaperone protein DnaK, SULFATE ION Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7469 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate Descriptor: Heat shock protein 70 Authors: Zuiderweg, E.R.P, Bertelsen, E.B. Deposit date: 2009-04-10 Release date: 2009-05-12 Last modified: 2021-08-18 Method: SOLUTION NMR Cite: Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
4R5G	Crystal structure of the DnaK C-terminus with the inhibitor PET-16 Descriptor: Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.4501 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5I	Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG Descriptor: Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ... Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9702 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5J	Crystal structure of the DnaK C-terminus (Dnak-SBD-A) Descriptor: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.361 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5L	Crystal structure of the DnaK C-terminus (Dnak-SBD-C) Descriptor: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION, ... Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9701 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... Authors: Wang, W, Hendrickson, W.A. Deposit date: 2021-07-04 Release date: 2023-07-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate Descriptor: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Moseng, M.A, Page, R.C. Deposit date: 2019-05-22 Release date: 2019-06-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... Authors: Moseng, M.A, Nix, J.C, Page, R.C. Deposit date: 2019-07-02 Release date: 2020-07-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
4B9Q	Open conformation of ATP-bound Hsp70 homolog DnaK Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION Authors: Kopp, J, Mayer, M.P, Sinning, I. Deposit date: 2012-09-06 Release date: 2012-11-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones Mol.Cell, 48, 2012
6G3S	Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Second structure of two TEW-HSP70 structures deposited. Descriptor: 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... Authors: Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. Deposit date: 2018-03-26 Release date: 2018-10-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PLoS ONE, 13, 2018
6G3R	Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Structure one of two TEW-HSP70 structures deposited. Descriptor: 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... Authors: Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. Deposit date: 2018-03-26 Release date: 2018-10-17 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.4 Å) Cite: The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PLoS ONE, 13, 2018
6GFA	Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 105 kDa, MAGNESIUM ION Authors: Gonzalez, D, Gotthard, G, Gozzi, G.J, Seigneuric, R, Neiers, F, Briand, L, Garrido, C. Deposit date: 2018-04-29 Release date: 2019-05-08 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy. Cell Death Differ., 27, 2020
5MKR	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation Descriptor: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A Authors: Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. Deposit date: 2016-12-05 Release date: 2017-03-01 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.87 Å) Cite: An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.87 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... Authors: Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. Deposit date: 2019-09-05 Release date: 2020-03-25 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
5XI9	Solution structure for human HSP70 substrate binding domain Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-26 Release date: 2018-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
5XIR	Solution structure for human HSP70 substrate binding domain L542Y mutant Descriptor: Heat shock 70 kDa protein 1A Authors: Hoshikawa, M, Tochio, N, Tate, S. Deposit date: 2017-04-27 Release date: 2018-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication. Molecules, 23, 2018
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state Descriptor: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... Authors: Vakonakis, I, Day, J. Deposit date: 2019-06-13 Release date: 2019-10-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.81 Å) Cite: ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... Authors: Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. Deposit date: 2016-11-07 Release date: 2016-12-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017

 

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