8XP5
The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
Functional Information from PROSITE/UniProt
site_id | PS00348 |
Number of Residues | 13 |
Details | P53 p53 family signature. MCNSSCMGGMNRR |
Chain | Residue | Details |
A | MET303-ARG315 |
site_id | PS01080 |
Number of Residues | 19 |
Details | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG |
Chain | Residue | Details |
A | LEU90-GLY108 |
site_id | PS01258 |
Number of Residues | 12 |
Details | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV |
Chain | Residue | Details |
A | TRP141-VAL152 |
site_id | PS01259 |
Number of Residues | 15 |
Details | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR |
Chain | Residue | Details |
A | VAL46-ARG60 |
site_id | PS01260 |
Number of Residues | 21 |
Details | BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW |
Chain | Residue | Details |
A | SER4-TRP24 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Cleavage; by caspase-1 |
Chain | Residue | Details |
A | TYR61 | |
B | TYR61 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391 |
Chain | Residue | Details |
A | ALA49 | |
B | ALA49 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720 |
Chain | Residue | Details |
A | ARG62 | |
B | ARG62 |
site_id | SWS_FT_FI4 |
Number of Residues | 380 |
Details | DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
Chain | Residue | Details |
A | THR168-LYS358 | |
B | THR168-LYS358 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 |
Chain | Residue | Details |
B | CYS242 | |
B | HIS245 | |
B | CYS304 | |
B | CYS308 | |
A | CYS242 | |
A | HIS245 | |
A | CYS304 | |
A | CYS308 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
Chain | Residue | Details |
A | LYS186 | |
B | LYS186 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine; by KAT6A => ECO:0000269|PubMed:23431171 |
Chain | Residue | Details |
B | LYS186 | |
A | LYS186 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
Chain | Residue | Details |
A | SER249 | |
A | SER335 | |
B | SER249 | |
B | SER335 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
Chain | Residue | Details |
A | THR350 | |
B | THR350 |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
Chain | Residue | Details |
A | LYS357 | |
A | LYS358 | |
B | LYS357 | |
B | LYS358 |