8XBT

The cryo-EM structure of the octameric RAD51 ring bound to the nucleosome with the linker DNA binding

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0010467	biological_process	gene expression
A	0016020	cellular_component	membrane
A	0032200	biological_process	telomere organization
A	0032991	cellular_component	protein-containing complex
A	0040029	biological_process	epigenetic regulation of gene expression
A	0043229	cellular_component	intracellular organelle
A	0045296	molecular_function	cadherin binding
A	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0008285	biological_process	negative regulation of cell population proliferation
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0043229	cellular_component	intracellular organelle
C	0043505	cellular_component	CENP-A containing nucleosome
C	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0070062	cellular_component	extracellular exosome
D	0000786	cellular_component	nucleosome
D	0001530	molecular_function	lipopolysaccharide binding
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0019731	biological_process	antibacterial humoral response
D	0031640	biological_process	killing of cells of another organism
D	0042742	biological_process	defense response to bacterium
D	0043229	cellular_component	intracellular organelle
D	0043505	cellular_component	CENP-A containing nucleosome
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061644	biological_process	protein localization to CENP-A containing chromatin
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0010467	biological_process	gene expression
E	0016020	cellular_component	membrane
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0040029	biological_process	epigenetic regulation of gene expression
E	0043229	cellular_component	intracellular organelle
E	0045296	molecular_function	cadherin binding
E	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0008285	biological_process	negative regulation of cell population proliferation
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
G	0043229	cellular_component	intracellular organelle
G	0043505	cellular_component	CENP-A containing nucleosome
G	0061644	biological_process	protein localization to CENP-A containing chromatin
G	0070062	cellular_component	extracellular exosome
H	0000786	cellular_component	nucleosome
H	0001530	molecular_function	lipopolysaccharide binding
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
H	0019731	biological_process	antibacterial humoral response
H	0031640	biological_process	killing of cells of another organism
H	0042742	biological_process	defense response to bacterium
H	0043229	cellular_component	intracellular organelle
H	0043505	cellular_component	CENP-A containing nucleosome
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0000150	molecular_function	DNA strand exchange activity
K	0000152	cellular_component	nuclear ubiquitin ligase complex
K	0000228	cellular_component	nuclear chromosome
K	0000722	biological_process	telomere maintenance via recombination
K	0000724	biological_process	double-strand break repair via homologous recombination
K	0000730	biological_process	DNA recombinase assembly
K	0000781	cellular_component	chromosome, telomeric region
K	0000785	cellular_component	chromatin
K	0000793	cellular_component	condensed chromosome
K	0000794	cellular_component	condensed nuclear chromosome
K	0000800	cellular_component	lateral element
K	0001673	cellular_component	male germ cell nucleus
K	0001932	biological_process	regulation of protein phosphorylation
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003697	molecular_function	single-stranded DNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0006268	biological_process	DNA unwinding involved in DNA replication
K	0006281	biological_process	DNA repair
K	0006310	biological_process	DNA recombination
K	0006312	biological_process	mitotic recombination
K	0006974	biological_process	DNA damage response
K	0007131	biological_process	reciprocal meiotic recombination
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0010569	biological_process	regulation of double-strand break repair via homologous recombination
K	0010833	biological_process	telomere maintenance via telomere lengthening
K	0016605	cellular_component	PML body
K	0017116	molecular_function	single-stranded DNA helicase activity
K	0019899	molecular_function	enzyme binding
K	0031297	biological_process	replication fork processing
K	0032200	biological_process	telomere organization
K	0032991	cellular_component	protein-containing complex
K	0035861	cellular_component	site of double-strand break
K	0036297	biological_process	interstrand cross-link repair
K	0042148	biological_process	DNA strand invasion
K	0042802	molecular_function	identical protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051106	biological_process	positive regulation of DNA ligation
K	0051321	biological_process	meiotic cell cycle
K	0070182	molecular_function	DNA polymerase binding
K	0070192	biological_process	chromosome organization involved in meiotic cell cycle
K	0071312	biological_process	cellular response to alkaloid
K	0071479	biological_process	cellular response to ionizing radiation
K	0072711	biological_process	cellular response to hydroxyurea
K	0072757	biological_process	cellular response to camptothecin
K	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
K	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
K	1990918	biological_process	double-strand break repair involved in meiotic recombination
K	2000001	biological_process	regulation of DNA damage checkpoint
L	0000150	molecular_function	DNA strand exchange activity
L	0000152	cellular_component	nuclear ubiquitin ligase complex
L	0000228	cellular_component	nuclear chromosome
L	0000722	biological_process	telomere maintenance via recombination
L	0000724	biological_process	double-strand break repair via homologous recombination
L	0000730	biological_process	DNA recombinase assembly
L	0000781	cellular_component	chromosome, telomeric region
L	0000785	cellular_component	chromatin
L	0000793	cellular_component	condensed chromosome
L	0000794	cellular_component	condensed nuclear chromosome
L	0000800	cellular_component	lateral element
L	0001673	cellular_component	male germ cell nucleus
L	0001932	biological_process	regulation of protein phosphorylation
L	0003677	molecular_function	DNA binding
L	0003682	molecular_function	chromatin binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003697	molecular_function	single-stranded DNA binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0006268	biological_process	DNA unwinding involved in DNA replication
L	0006281	biological_process	DNA repair
L	0006310	biological_process	DNA recombination
L	0006312	biological_process	mitotic recombination
L	0006974	biological_process	DNA damage response
L	0007131	biological_process	reciprocal meiotic recombination
L	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0010569	biological_process	regulation of double-strand break repair via homologous recombination
L	0010833	biological_process	telomere maintenance via telomere lengthening
L	0016605	cellular_component	PML body
L	0017116	molecular_function	single-stranded DNA helicase activity
L	0019899	molecular_function	enzyme binding
L	0031297	biological_process	replication fork processing
L	0032200	biological_process	telomere organization
L	0032991	cellular_component	protein-containing complex
L	0035861	cellular_component	site of double-strand break
L	0036297	biological_process	interstrand cross-link repair
L	0042148	biological_process	DNA strand invasion
L	0042802	molecular_function	identical protein binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0051106	biological_process	positive regulation of DNA ligation
L	0051321	biological_process	meiotic cell cycle
L	0070182	molecular_function	DNA polymerase binding
L	0070192	biological_process	chromosome organization involved in meiotic cell cycle
L	0071312	biological_process	cellular response to alkaloid
L	0071479	biological_process	cellular response to ionizing radiation
L	0072711	biological_process	cellular response to hydroxyurea
L	0072757	biological_process	cellular response to camptothecin
L	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
L	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
L	1990918	biological_process	double-strand break repair involved in meiotic recombination
L	2000001	biological_process	regulation of DNA damage checkpoint
M	0000150	molecular_function	DNA strand exchange activity
M	0000152	cellular_component	nuclear ubiquitin ligase complex
M	0000228	cellular_component	nuclear chromosome
M	0000722	biological_process	telomere maintenance via recombination
M	0000724	biological_process	double-strand break repair via homologous recombination
M	0000730	biological_process	DNA recombinase assembly
M	0000781	cellular_component	chromosome, telomeric region
M	0000785	cellular_component	chromatin
M	0000793	cellular_component	condensed chromosome
M	0000794	cellular_component	condensed nuclear chromosome
M	0000800	cellular_component	lateral element
M	0001673	cellular_component	male germ cell nucleus
M	0001932	biological_process	regulation of protein phosphorylation
M	0003677	molecular_function	DNA binding
M	0003682	molecular_function	chromatin binding
M	0003690	molecular_function	double-stranded DNA binding
M	0003697	molecular_function	single-stranded DNA binding
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0005813	cellular_component	centrosome
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0006268	biological_process	DNA unwinding involved in DNA replication
M	0006281	biological_process	DNA repair
M	0006310	biological_process	DNA recombination
M	0006312	biological_process	mitotic recombination
M	0006974	biological_process	DNA damage response
M	0007131	biological_process	reciprocal meiotic recombination
M	0008094	molecular_function	ATP-dependent activity, acting on DNA
M	0010569	biological_process	regulation of double-strand break repair via homologous recombination
M	0010833	biological_process	telomere maintenance via telomere lengthening
M	0016605	cellular_component	PML body
M	0017116	molecular_function	single-stranded DNA helicase activity
M	0019899	molecular_function	enzyme binding
M	0031297	biological_process	replication fork processing
M	0032200	biological_process	telomere organization
M	0032991	cellular_component	protein-containing complex
M	0035861	cellular_component	site of double-strand break
M	0036297	biological_process	interstrand cross-link repair
M	0042148	biological_process	DNA strand invasion
M	0042802	molecular_function	identical protein binding
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0051106	biological_process	positive regulation of DNA ligation
M	0051321	biological_process	meiotic cell cycle
M	0070182	molecular_function	DNA polymerase binding
M	0070192	biological_process	chromosome organization involved in meiotic cell cycle
M	0071312	biological_process	cellular response to alkaloid
M	0071479	biological_process	cellular response to ionizing radiation
M	0072711	biological_process	cellular response to hydroxyurea
M	0072757	biological_process	cellular response to camptothecin
M	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
M	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
M	1990918	biological_process	double-strand break repair involved in meiotic recombination
M	2000001	biological_process	regulation of DNA damage checkpoint
N	0000150	molecular_function	DNA strand exchange activity
N	0000152	cellular_component	nuclear ubiquitin ligase complex
N	0000228	cellular_component	nuclear chromosome
N	0000722	biological_process	telomere maintenance via recombination
N	0000724	biological_process	double-strand break repair via homologous recombination
N	0000730	biological_process	DNA recombinase assembly
N	0000781	cellular_component	chromosome, telomeric region
N	0000785	cellular_component	chromatin
N	0000793	cellular_component	condensed chromosome
N	0000794	cellular_component	condensed nuclear chromosome
N	0000800	cellular_component	lateral element
N	0001673	cellular_component	male germ cell nucleus
N	0001932	biological_process	regulation of protein phosphorylation
N	0003677	molecular_function	DNA binding
N	0003682	molecular_function	chromatin binding
N	0003690	molecular_function	double-stranded DNA binding
N	0003697	molecular_function	single-stranded DNA binding
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0005813	cellular_component	centrosome
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0006268	biological_process	DNA unwinding involved in DNA replication
N	0006281	biological_process	DNA repair
N	0006310	biological_process	DNA recombination
N	0006312	biological_process	mitotic recombination
N	0006974	biological_process	DNA damage response
N	0007131	biological_process	reciprocal meiotic recombination
N	0008094	molecular_function	ATP-dependent activity, acting on DNA
N	0010569	biological_process	regulation of double-strand break repair via homologous recombination
N	0010833	biological_process	telomere maintenance via telomere lengthening
N	0016605	cellular_component	PML body
N	0017116	molecular_function	single-stranded DNA helicase activity
N	0019899	molecular_function	enzyme binding
N	0031297	biological_process	replication fork processing
N	0032200	biological_process	telomere organization
N	0032991	cellular_component	protein-containing complex
N	0035861	cellular_component	site of double-strand break
N	0036297	biological_process	interstrand cross-link repair
N	0042148	biological_process	DNA strand invasion
N	0042802	molecular_function	identical protein binding
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0051106	biological_process	positive regulation of DNA ligation
N	0051321	biological_process	meiotic cell cycle
N	0070182	molecular_function	DNA polymerase binding
N	0070192	biological_process	chromosome organization involved in meiotic cell cycle
N	0071312	biological_process	cellular response to alkaloid
N	0071479	biological_process	cellular response to ionizing radiation
N	0072711	biological_process	cellular response to hydroxyurea
N	0072757	biological_process	cellular response to camptothecin
N	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
N	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
N	1990918	biological_process	double-strand break repair involved in meiotic recombination
N	2000001	biological_process	regulation of DNA damage checkpoint
O	0000150	molecular_function	DNA strand exchange activity
O	0000152	cellular_component	nuclear ubiquitin ligase complex
O	0000228	cellular_component	nuclear chromosome
O	0000722	biological_process	telomere maintenance via recombination
O	0000724	biological_process	double-strand break repair via homologous recombination
O	0000730	biological_process	DNA recombinase assembly
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0000793	cellular_component	condensed chromosome
O	0000794	cellular_component	condensed nuclear chromosome
O	0000800	cellular_component	lateral element
O	0001673	cellular_component	male germ cell nucleus
O	0001932	biological_process	regulation of protein phosphorylation
O	0003677	molecular_function	DNA binding
O	0003682	molecular_function	chromatin binding
O	0003690	molecular_function	double-stranded DNA binding
O	0003697	molecular_function	single-stranded DNA binding
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0005813	cellular_component	centrosome
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0006268	biological_process	DNA unwinding involved in DNA replication
O	0006281	biological_process	DNA repair
O	0006310	biological_process	DNA recombination
O	0006312	biological_process	mitotic recombination
O	0006974	biological_process	DNA damage response
O	0007131	biological_process	reciprocal meiotic recombination
O	0008094	molecular_function	ATP-dependent activity, acting on DNA
O	0010569	biological_process	regulation of double-strand break repair via homologous recombination
O	0010833	biological_process	telomere maintenance via telomere lengthening
O	0016605	cellular_component	PML body
O	0017116	molecular_function	single-stranded DNA helicase activity
O	0019899	molecular_function	enzyme binding
O	0031297	biological_process	replication fork processing
O	0032200	biological_process	telomere organization
O	0032991	cellular_component	protein-containing complex
O	0035861	cellular_component	site of double-strand break
O	0036297	biological_process	interstrand cross-link repair
O	0042148	biological_process	DNA strand invasion
O	0042802	molecular_function	identical protein binding
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0051106	biological_process	positive regulation of DNA ligation
O	0051321	biological_process	meiotic cell cycle
O	0070182	molecular_function	DNA polymerase binding
O	0070192	biological_process	chromosome organization involved in meiotic cell cycle
O	0071312	biological_process	cellular response to alkaloid
O	0071479	biological_process	cellular response to ionizing radiation
O	0072711	biological_process	cellular response to hydroxyurea
O	0072757	biological_process	cellular response to camptothecin
O	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
O	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
O	1990918	biological_process	double-strand break repair involved in meiotic recombination
O	2000001	biological_process	regulation of DNA damage checkpoint
P	0000150	molecular_function	DNA strand exchange activity
P	0000152	cellular_component	nuclear ubiquitin ligase complex
P	0000228	cellular_component	nuclear chromosome
P	0000722	biological_process	telomere maintenance via recombination
P	0000724	biological_process	double-strand break repair via homologous recombination
P	0000730	biological_process	DNA recombinase assembly
P	0000781	cellular_component	chromosome, telomeric region
P	0000785	cellular_component	chromatin
P	0000793	cellular_component	condensed chromosome
P	0000794	cellular_component	condensed nuclear chromosome
P	0000800	cellular_component	lateral element
P	0001673	cellular_component	male germ cell nucleus
P	0001932	biological_process	regulation of protein phosphorylation
P	0003677	molecular_function	DNA binding
P	0003682	molecular_function	chromatin binding
P	0003690	molecular_function	double-stranded DNA binding
P	0003697	molecular_function	single-stranded DNA binding
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005730	cellular_component	nucleolus
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0005813	cellular_component	centrosome
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0006268	biological_process	DNA unwinding involved in DNA replication
P	0006281	biological_process	DNA repair
P	0006310	biological_process	DNA recombination
P	0006312	biological_process	mitotic recombination
P	0006974	biological_process	DNA damage response
P	0007131	biological_process	reciprocal meiotic recombination
P	0008094	molecular_function	ATP-dependent activity, acting on DNA
P	0010569	biological_process	regulation of double-strand break repair via homologous recombination
P	0010833	biological_process	telomere maintenance via telomere lengthening
P	0016605	cellular_component	PML body
P	0017116	molecular_function	single-stranded DNA helicase activity
P	0019899	molecular_function	enzyme binding
P	0031297	biological_process	replication fork processing
P	0032200	biological_process	telomere organization
P	0032991	cellular_component	protein-containing complex
P	0035861	cellular_component	site of double-strand break
P	0036297	biological_process	interstrand cross-link repair
P	0042148	biological_process	DNA strand invasion
P	0042802	molecular_function	identical protein binding
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0051106	biological_process	positive regulation of DNA ligation
P	0051321	biological_process	meiotic cell cycle
P	0070182	molecular_function	DNA polymerase binding
P	0070192	biological_process	chromosome organization involved in meiotic cell cycle
P	0071312	biological_process	cellular response to alkaloid
P	0071479	biological_process	cellular response to ionizing radiation
P	0072711	biological_process	cellular response to hydroxyurea
P	0072757	biological_process	cellular response to camptothecin
P	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
P	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
P	1990918	biological_process	double-strand break repair involved in meiotic recombination
P	2000001	biological_process	regulation of DNA damage checkpoint
Q	0000150	molecular_function	DNA strand exchange activity
Q	0000152	cellular_component	nuclear ubiquitin ligase complex
Q	0000228	cellular_component	nuclear chromosome
Q	0000722	biological_process	telomere maintenance via recombination
Q	0000724	biological_process	double-strand break repair via homologous recombination
Q	0000730	biological_process	DNA recombinase assembly
Q	0000781	cellular_component	chromosome, telomeric region
Q	0000785	cellular_component	chromatin
Q	0000793	cellular_component	condensed chromosome
Q	0000794	cellular_component	condensed nuclear chromosome
Q	0000800	cellular_component	lateral element
Q	0001673	cellular_component	male germ cell nucleus
Q	0001932	biological_process	regulation of protein phosphorylation
Q	0003677	molecular_function	DNA binding
Q	0003682	molecular_function	chromatin binding
Q	0003690	molecular_function	double-stranded DNA binding
Q	0003697	molecular_function	single-stranded DNA binding
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005730	cellular_component	nucleolus
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005759	cellular_component	mitochondrial matrix
Q	0005813	cellular_component	centrosome
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0006268	biological_process	DNA unwinding involved in DNA replication
Q	0006281	biological_process	DNA repair
Q	0006310	biological_process	DNA recombination
Q	0006312	biological_process	mitotic recombination
Q	0006974	biological_process	DNA damage response
Q	0007131	biological_process	reciprocal meiotic recombination
Q	0008094	molecular_function	ATP-dependent activity, acting on DNA
Q	0010569	biological_process	regulation of double-strand break repair via homologous recombination
Q	0010833	biological_process	telomere maintenance via telomere lengthening
Q	0016605	cellular_component	PML body
Q	0017116	molecular_function	single-stranded DNA helicase activity
Q	0019899	molecular_function	enzyme binding
Q	0031297	biological_process	replication fork processing
Q	0032200	biological_process	telomere organization
Q	0032991	cellular_component	protein-containing complex
Q	0035861	cellular_component	site of double-strand break
Q	0036297	biological_process	interstrand cross-link repair
Q	0042148	biological_process	DNA strand invasion
Q	0042802	molecular_function	identical protein binding
Q	0048471	cellular_component	perinuclear region of cytoplasm
Q	0051106	biological_process	positive regulation of DNA ligation
Q	0051321	biological_process	meiotic cell cycle
Q	0070182	molecular_function	DNA polymerase binding
Q	0070192	biological_process	chromosome organization involved in meiotic cell cycle
Q	0071312	biological_process	cellular response to alkaloid
Q	0071479	biological_process	cellular response to ionizing radiation
Q	0072711	biological_process	cellular response to hydroxyurea
Q	0072757	biological_process	cellular response to camptothecin
Q	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
Q	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
Q	1990918	biological_process	double-strand break repair involved in meiotic recombination
Q	2000001	biological_process	regulation of DNA damage checkpoint
R	0000150	molecular_function	DNA strand exchange activity
R	0000152	cellular_component	nuclear ubiquitin ligase complex
R	0000228	cellular_component	nuclear chromosome
R	0000722	biological_process	telomere maintenance via recombination
R	0000724	biological_process	double-strand break repair via homologous recombination
R	0000730	biological_process	DNA recombinase assembly
R	0000781	cellular_component	chromosome, telomeric region
R	0000785	cellular_component	chromatin
R	0000793	cellular_component	condensed chromosome
R	0000794	cellular_component	condensed nuclear chromosome
R	0000800	cellular_component	lateral element
R	0001673	cellular_component	male germ cell nucleus
R	0001932	biological_process	regulation of protein phosphorylation
R	0003677	molecular_function	DNA binding
R	0003682	molecular_function	chromatin binding
R	0003690	molecular_function	double-stranded DNA binding
R	0003697	molecular_function	single-stranded DNA binding
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005730	cellular_component	nucleolus
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0005813	cellular_component	centrosome
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0006268	biological_process	DNA unwinding involved in DNA replication
R	0006281	biological_process	DNA repair
R	0006310	biological_process	DNA recombination
R	0006312	biological_process	mitotic recombination
R	0006974	biological_process	DNA damage response
R	0007131	biological_process	reciprocal meiotic recombination
R	0008094	molecular_function	ATP-dependent activity, acting on DNA
R	0010569	biological_process	regulation of double-strand break repair via homologous recombination
R	0010833	biological_process	telomere maintenance via telomere lengthening
R	0016605	cellular_component	PML body
R	0017116	molecular_function	single-stranded DNA helicase activity
R	0019899	molecular_function	enzyme binding
R	0031297	biological_process	replication fork processing
R	0032200	biological_process	telomere organization
R	0032991	cellular_component	protein-containing complex
R	0035861	cellular_component	site of double-strand break
R	0036297	biological_process	interstrand cross-link repair
R	0042148	biological_process	DNA strand invasion
R	0042802	molecular_function	identical protein binding
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0051106	biological_process	positive regulation of DNA ligation
R	0051321	biological_process	meiotic cell cycle
R	0070182	molecular_function	DNA polymerase binding
R	0070192	biological_process	chromosome organization involved in meiotic cell cycle
R	0071312	biological_process	cellular response to alkaloid
R	0071479	biological_process	cellular response to ionizing radiation
R	0072711	biological_process	cellular response to hydroxyurea
R	0072757	biological_process	cellular response to camptothecin
R	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
R	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
R	1990918	biological_process	double-strand break repair involved in meiotic recombination
R	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
K	GLY127
L	GLY127
M	GLY127
N	GLY127
O	GLY127
P	GLY127
Q	GLY127
R	GLY127

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
K	ALA2
L	ALA2
M	ALA2
N	ALA2
O	ALA2
P	ALA2
Q	ALA2
R	ALA2

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421

Chain	Residue	Details
K	THR13
H	LYS11
H	LYS15
H	LYS16
H	LYS20
H	LYS23
H	LYS43
H	LYS85
L	THR13
M	THR13
N	THR13
O	THR13
P	THR13
Q	THR13
R	THR13
H	LYS5

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PLK1 => ECO:0000269|PubMed:22325354, ECO:0000269|PubMed:26811421

Chain	Residue	Details
K	SER14
L	SER14
M	SER14
N	SER14
O	SER14
P	SER14
Q	SER14
R	SER14

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:9461559

Chain	Residue	Details
K	TYR54
L	TYR54
M	TYR54
N	TYR54
O	TYR54
P	TYR54
Q	TYR54
R	TYR54

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by CHEK1 => ECO:0000269|PubMed:15665856

Chain	Residue	Details
K	THR309
L	THR309
M	THR309
N	THR309
O	THR309
P	THR309
Q	THR309
R	THR309

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23393192

Chain	Residue	Details
K	LYS58
N	LYS58
N	LYS64
O	LYS58
O	LYS64
P	LYS58
P	LYS64
Q	LYS58
H	LYS24
Q	LYS64
R	LYS58
R	LYS64
K	LYS64
L	LYS58
L	LYS64
M	LYS58
M	LYS64

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
D	LYS34
D	LYS116
D	LYS120
H	LYS34
H	LYS116
H	LYS120

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000250|UniProtKB:Q64475

Chain	Residue	Details
D	GLU35
H	GLU35
C	LYS125
G	LYS118
G	LYS119
G	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:Q64475

Chain	Residue	Details
D	SER36
H	SER36
E	LYS14
E	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16627869

Chain	Residue	Details
D	LYS46
D	LYS108
H	LYS46
H	LYS108

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000269|PubMed:24681537

Chain	Residue	Details
D	LYS57
H	LYS57
E	LYS18
G	LYS119

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Dimethylated arginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
D	ARG79
H	ARG79

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08

Chain	Residue	Details
D	ARG86
D	ARG92
H	ARG86
H	ARG92

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729

Chain	Residue	Details
D	THR115
H	THR115
F	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
D	SER112
H	SER112
B	LYS79
F	LYS20
F	LYS59
F	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876

Chain	Residue	Details
D	LYS5
H	LYS5

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563

Chain	Residue	Details
A	LYS37
D	LYS120
H	LYS120

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6

Chain	Residue	Details
D	LYS20
H	LYS20

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816

Chain	Residue	Details
D	LYS34
H	LYS34

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711

Chain	Residue	Details
A	LYS79
E	LYS79

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
A	THR80
E	THR80

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
A	SER86
E	SER86

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
A	THR107
E	THR107

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
A	LYS115
E	LYS115

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
A	LYS122
E	LYS122

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
A	LYS18
E	LYS18

---