8UXX

Arp2/3 branch junction complex, BeFx state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000281	biological_process	mitotic cytokinesis
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005885	cellular_component	Arp2/3 protein complex
A	0006897	biological_process	endocytosis
A	0030036	biological_process	actin cytoskeleton organization
A	0030041	biological_process	actin filament polymerization
A	0030479	cellular_component	actin cortical patch
A	0032153	cellular_component	cell division site
A	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
A	0044396	biological_process	actin cortical patch organization
A	0051015	molecular_function	actin filament binding
A	0051285	cellular_component	cell cortex of cell tip
B	0000147	biological_process	actin cortical patch assembly
B	0003779	molecular_function	actin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005885	cellular_component	Arp2/3 protein complex
B	0005938	cellular_component	cell cortex
B	0006897	biological_process	endocytosis
B	0030479	cellular_component	actin cortical patch
B	0031097	cellular_component	medial cortex
B	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
B	0051015	molecular_function	actin filament binding
B	0051285	cellular_component	cell cortex of cell tip
C	0000147	biological_process	actin cortical patch assembly
C	0003779	molecular_function	actin binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005885	cellular_component	Arp2/3 protein complex
C	0006897	biological_process	endocytosis
C	0030036	biological_process	actin cytoskeleton organization
C	0030479	cellular_component	actin cortical patch
C	0030866	biological_process	cortical actin cytoskeleton organization
C	0032153	cellular_component	cell division site
C	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
C	0051015	molecular_function	actin filament binding
C	0051286	cellular_component	cell tip
D	0000147	biological_process	actin cortical patch assembly
D	0003779	molecular_function	actin binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005885	cellular_component	Arp2/3 protein complex
D	0006897	biological_process	endocytosis
D	0030479	cellular_component	actin cortical patch
D	0032153	cellular_component	cell division site
D	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
D	0051015	molecular_function	actin filament binding
D	0051286	cellular_component	cell tip
E	0000147	biological_process	actin cortical patch assembly
E	0003779	molecular_function	actin binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005826	cellular_component	actomyosin contractile ring
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005885	cellular_component	Arp2/3 protein complex
E	0006897	biological_process	endocytosis
E	0007163	biological_process	establishment or maintenance of cell polarity
E	0030479	cellular_component	actin cortical patch
E	0032153	cellular_component	cell division site
E	0032432	cellular_component	actin filament bundle
E	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
E	0044396	biological_process	actin cortical patch organization
E	0051015	molecular_function	actin filament binding
E	0051286	cellular_component	cell tip
F	0000147	biological_process	actin cortical patch assembly
F	0003779	molecular_function	actin binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005885	cellular_component	Arp2/3 protein complex
F	0006897	biological_process	endocytosis
F	0030479	cellular_component	actin cortical patch
F	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
F	0051015	molecular_function	actin filament binding
G	0000147	biological_process	actin cortical patch assembly
G	0003779	molecular_function	actin binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005885	cellular_component	Arp2/3 protein complex
G	0006897	biological_process	endocytosis
G	0030479	cellular_component	actin cortical patch
G	0034314	biological_process	Arp2/3 complex-mediated actin nucleation
G	0043332	cellular_component	mating projection tip
G	0051015	molecular_function	actin filament binding
H	0000287	molecular_function	magnesium ion binding
H	0001725	cellular_component	stress fiber
H	0003785	molecular_function	actin monomer binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005523	molecular_function	tropomyosin binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0010628	biological_process	positive regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0030027	cellular_component	lamellipodium
H	0030041	biological_process	actin filament polymerization
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0031013	molecular_function	troponin I binding
H	0031432	molecular_function	titin binding
H	0031941	cellular_component	filamentous actin
H	0032036	molecular_function	myosin heavy chain binding
H	0032432	cellular_component	actin filament bundle
H	0042802	molecular_function	identical protein binding
H	0044297	cellular_component	cell body
H	0048306	molecular_function	calcium-dependent protein binding
H	0048741	biological_process	skeletal muscle fiber development
H	0051017	biological_process	actin filament bundle assembly
H	0090131	biological_process	mesenchyme migration
H	0098723	cellular_component	skeletal muscle myofibril
H	0140660	molecular_function	cytoskeletal motor activator activity
I	0000287	molecular_function	magnesium ion binding
I	0001725	cellular_component	stress fiber
I	0003785	molecular_function	actin monomer binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005523	molecular_function	tropomyosin binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005865	cellular_component	striated muscle thin filament
I	0005884	cellular_component	actin filament
I	0010628	biological_process	positive regulation of gene expression
I	0016787	molecular_function	hydrolase activity
I	0019904	molecular_function	protein domain specific binding
I	0030027	cellular_component	lamellipodium
I	0030041	biological_process	actin filament polymerization
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0031013	molecular_function	troponin I binding
I	0031432	molecular_function	titin binding
I	0031941	cellular_component	filamentous actin
I	0032036	molecular_function	myosin heavy chain binding
I	0032432	cellular_component	actin filament bundle
I	0042802	molecular_function	identical protein binding
I	0044297	cellular_component	cell body
I	0048306	molecular_function	calcium-dependent protein binding
I	0048741	biological_process	skeletal muscle fiber development
I	0051017	biological_process	actin filament bundle assembly
I	0090131	biological_process	mesenchyme migration
I	0098723	cellular_component	skeletal muscle myofibril
I	0140660	molecular_function	cytoskeletal motor activator activity
M	0000287	molecular_function	magnesium ion binding
M	0001725	cellular_component	stress fiber
M	0003785	molecular_function	actin monomer binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005523	molecular_function	tropomyosin binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005865	cellular_component	striated muscle thin filament
M	0005884	cellular_component	actin filament
M	0010628	biological_process	positive regulation of gene expression
M	0016787	molecular_function	hydrolase activity
M	0019904	molecular_function	protein domain specific binding
M	0030027	cellular_component	lamellipodium
M	0030041	biological_process	actin filament polymerization
M	0030175	cellular_component	filopodium
M	0030240	biological_process	skeletal muscle thin filament assembly
M	0031013	molecular_function	troponin I binding
M	0031432	molecular_function	titin binding
M	0031941	cellular_component	filamentous actin
M	0032036	molecular_function	myosin heavy chain binding
M	0032432	cellular_component	actin filament bundle
M	0042802	molecular_function	identical protein binding
M	0044297	cellular_component	cell body
M	0048306	molecular_function	calcium-dependent protein binding
M	0048741	biological_process	skeletal muscle fiber development
M	0051017	biological_process	actin filament bundle assembly
M	0090131	biological_process	mesenchyme migration
M	0098723	cellular_component	skeletal muscle myofibril
M	0140660	molecular_function	cytoskeletal motor activator activity
N	0000287	molecular_function	magnesium ion binding
N	0001725	cellular_component	stress fiber
N	0003785	molecular_function	actin monomer binding
N	0005509	molecular_function	calcium ion binding
N	0005515	molecular_function	protein binding
N	0005523	molecular_function	tropomyosin binding
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005865	cellular_component	striated muscle thin filament
N	0005884	cellular_component	actin filament
N	0010628	biological_process	positive regulation of gene expression
N	0016787	molecular_function	hydrolase activity
N	0019904	molecular_function	protein domain specific binding
N	0030027	cellular_component	lamellipodium
N	0030041	biological_process	actin filament polymerization
N	0030175	cellular_component	filopodium
N	0030240	biological_process	skeletal muscle thin filament assembly
N	0031013	molecular_function	troponin I binding
N	0031432	molecular_function	titin binding
N	0031941	cellular_component	filamentous actin
N	0032036	molecular_function	myosin heavy chain binding
N	0032432	cellular_component	actin filament bundle
N	0042802	molecular_function	identical protein binding
N	0044297	cellular_component	cell body
N	0048306	molecular_function	calcium-dependent protein binding
N	0048741	biological_process	skeletal muscle fiber development
N	0051017	biological_process	actin filament bundle assembly
N	0090131	biological_process	mesenchyme migration
N	0098723	cellular_component	skeletal muscle myofibril
N	0140660	molecular_function	cytoskeletal motor activator activity
O	0000287	molecular_function	magnesium ion binding
O	0001725	cellular_component	stress fiber
O	0003785	molecular_function	actin monomer binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005523	molecular_function	tropomyosin binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005865	cellular_component	striated muscle thin filament
O	0005884	cellular_component	actin filament
O	0010628	biological_process	positive regulation of gene expression
O	0016787	molecular_function	hydrolase activity
O	0019904	molecular_function	protein domain specific binding
O	0030027	cellular_component	lamellipodium
O	0030041	biological_process	actin filament polymerization
O	0030175	cellular_component	filopodium
O	0030240	biological_process	skeletal muscle thin filament assembly
O	0031013	molecular_function	troponin I binding
O	0031432	molecular_function	titin binding
O	0031941	cellular_component	filamentous actin
O	0032036	molecular_function	myosin heavy chain binding
O	0032432	cellular_component	actin filament bundle
O	0042802	molecular_function	identical protein binding
O	0044297	cellular_component	cell body
O	0048306	molecular_function	calcium-dependent protein binding
O	0048741	biological_process	skeletal muscle fiber development
O	0051017	biological_process	actin filament bundle assembly
O	0090131	biological_process	mesenchyme migration
O	0098723	cellular_component	skeletal muscle myofibril
O	0140660	molecular_function	cytoskeletal motor activator activity
P	0000287	molecular_function	magnesium ion binding
P	0001725	cellular_component	stress fiber
P	0003785	molecular_function	actin monomer binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005523	molecular_function	tropomyosin binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005865	cellular_component	striated muscle thin filament
P	0005884	cellular_component	actin filament
P	0010628	biological_process	positive regulation of gene expression
P	0016787	molecular_function	hydrolase activity
P	0019904	molecular_function	protein domain specific binding
P	0030027	cellular_component	lamellipodium
P	0030041	biological_process	actin filament polymerization
P	0030175	cellular_component	filopodium
P	0030240	biological_process	skeletal muscle thin filament assembly
P	0031013	molecular_function	troponin I binding
P	0031432	molecular_function	titin binding
P	0031941	cellular_component	filamentous actin
P	0032036	molecular_function	myosin heavy chain binding
P	0032432	cellular_component	actin filament bundle
P	0042802	molecular_function	identical protein binding
P	0044297	cellular_component	cell body
P	0048306	molecular_function	calcium-dependent protein binding
P	0048741	biological_process	skeletal muscle fiber development
P	0051017	biological_process	actin filament bundle assembly
P	0090131	biological_process	mesenchyme migration
P	0098723	cellular_component	skeletal muscle myofibril
P	0140660	molecular_function	cytoskeletal motor activator activity
Q	0000287	molecular_function	magnesium ion binding
Q	0001725	cellular_component	stress fiber
Q	0003785	molecular_function	actin monomer binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005523	molecular_function	tropomyosin binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005865	cellular_component	striated muscle thin filament
Q	0005884	cellular_component	actin filament
Q	0010628	biological_process	positive regulation of gene expression
Q	0016787	molecular_function	hydrolase activity
Q	0019904	molecular_function	protein domain specific binding
Q	0030027	cellular_component	lamellipodium
Q	0030041	biological_process	actin filament polymerization
Q	0030175	cellular_component	filopodium
Q	0030240	biological_process	skeletal muscle thin filament assembly
Q	0031013	molecular_function	troponin I binding
Q	0031432	molecular_function	titin binding
Q	0031941	cellular_component	filamentous actin
Q	0032036	molecular_function	myosin heavy chain binding
Q	0032432	cellular_component	actin filament bundle
Q	0042802	molecular_function	identical protein binding
Q	0044297	cellular_component	cell body
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0048741	biological_process	skeletal muscle fiber development
Q	0051017	biological_process	actin filament bundle assembly
Q	0090131	biological_process	mesenchyme migration
Q	0098723	cellular_component	skeletal muscle myofibril
Q	0140660	molecular_function	cytoskeletal motor activator activity
R	0000287	molecular_function	magnesium ion binding
R	0001725	cellular_component	stress fiber
R	0003785	molecular_function	actin monomer binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005523	molecular_function	tropomyosin binding
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005865	cellular_component	striated muscle thin filament
R	0005884	cellular_component	actin filament
R	0010628	biological_process	positive regulation of gene expression
R	0016787	molecular_function	hydrolase activity
R	0019904	molecular_function	protein domain specific binding
R	0030027	cellular_component	lamellipodium
R	0030041	biological_process	actin filament polymerization
R	0030175	cellular_component	filopodium
R	0030240	biological_process	skeletal muscle thin filament assembly
R	0031013	molecular_function	troponin I binding
R	0031432	molecular_function	titin binding
R	0031941	cellular_component	filamentous actin
R	0032036	molecular_function	myosin heavy chain binding
R	0032432	cellular_component	actin filament bundle
R	0042802	molecular_function	identical protein binding
R	0044297	cellular_component	cell body
R	0048306	molecular_function	calcium-dependent protein binding
R	0048741	biological_process	skeletal muscle fiber development
R	0051017	biological_process	actin filament bundle assembly
R	0090131	biological_process	mesenchyme migration
R	0098723	cellular_component	skeletal muscle myofibril
R	0140660	molecular_function	cytoskeletal motor activator activity

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
H	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
H	LEU104-ARG116
B	LEU104-ARG116
A	LEU127-ARG139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000250|UniProtKB:P62737

Chain	Residue	Details
H	CYS0
I	CYS0
M	CYS0
N	CYS0
O	CYS0
P	CYS0
Q	CYS0
R	CYS0

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylaspartate; in Actin, alpha skeletal muscle => ECO:0000269|PubMed:456601

Chain	Residue	Details
H	ASP1
I	ASP1
M	ASP1
N	ASP1
O	ASP1
P	ASP1
Q	ASP1
R	ASP1

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P68134

Chain	Residue	Details
H	MET44
O	MET47
P	MET44
P	MET47
Q	MET44
Q	MET47
R	MET44
R	MET47
H	MET47
I	MET44
I	MET47
M	MET44
M	MET47
N	MET44
N	MET47
O	MET44

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-malonyllysine => ECO:0000250

Chain	Residue	Details
H	LYS61
I	LYS61
M	LYS61
N	LYS61
O	LYS61
P	LYS61
Q	LYS61
R	LYS61

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:12356759, ECO:0007744|PDB:1MDU

Chain	Residue	Details
H	HIC73
I	HIC73
M	HIC73
N	HIC73
O	HIC73
P	HIC73
Q	HIC73
R	HIC73

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68133

Chain	Residue	Details
H	LYS84
I	LYS84
M	LYS84
N	LYS84
O	LYS84
P	LYS84
Q	LYS84
R	LYS84

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: ADP-ribosylarginine; by SpvB => ECO:0000305|PubMed:16905096

Chain	Residue	Details
H	ARG177
I	ARG177
M	ARG177
N	ARG177
O	ARG177
P	ARG177
Q	ARG177
R	ARG177

---