Functional Information from PROSITE/UniProt
| site_id | PS00388 |
| Number of Residues | 23 |
| Details | PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdralSiFSPdGHifQVEYAleA |
| Chain | Residue | Details |
| A | TYR12-ALA34 | |
| C | TYR6-SER28 | |
| D | TYR4-ALA26 | |
| B | TYR5-ALA27 | |
| E | TYR8-ALA30 | |
| G | TYR8-ALA30 | |
| F | TYR6-ALA28 |
| site_id | PS00854 |
| Number of Residues | 48 |
| Details | PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIaGedFAVLAGDtrnitdysinsryep.KvfdcgdnivmsanGfaAD |
| Chain | Residue | Details |
| d | LEU32-ASP79 | |
| D | VAL34-ASP81 | |
| c | LEU79-ASP126 | |
| I | VAL33-ASP80 | |
| h | ILE45-ASP92 | |
| b | LEU5-ASP52 | |
| a | VAL13-ASP59 | |
| e | MET23-ASP70 | |
| C | ILE36-ASP83 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:9087403 |
| Chain | Residue | Details |
| C | LYS199 | |
| C | LYS231 | |
| T | LYS100 | |
| T | LYS199 | |
| T | LYS231 | |
| N | THR20 | |
| e | THR20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| e | MET1 | |
| a | LYS70 | |
| N | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| E | SER251 | |
| R | LYS232 | |
| V | SER251 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 177 |
| Chain | Residue | Details |
| I | THR30 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| I | ASP46 | activator, steric locator |
| I | ARG48 | activator |
| I | LYS62 | activator, electrostatic stabiliser |
| I | GLY76 | electrostatic stabiliser |
| I | SER158 | activator, electrostatic stabiliser |
| I | ASP195 | activator, steric locator |
| I | SER198 | activator, electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 177 |
| Chain | Residue | Details |
| Z | THR30 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| Z | ASP46 | activator, steric locator |
| Z | ARG48 | activator |
| Z | LYS62 | activator, electrostatic stabiliser |
| Z | GLY76 | electrostatic stabiliser |
| Z | SER158 | activator, electrostatic stabiliser |
| Z | ASP195 | activator, steric locator |
| Z | SER198 | activator, electrostatic stabiliser |
