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8U4O

Structure of CXCL12-bound CXCR4/Gi complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
J0001666biological_processresponse to hypoxia
J0001764biological_processneuron migration
J0001938biological_processpositive regulation of endothelial cell proliferation
J0005102molecular_functionsignaling receptor binding
J0005125molecular_functioncytokine activity
J0005178molecular_functionintegrin binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0006874biological_processintracellular calcium ion homeostasis
J0006935biological_processchemotaxis
J0006955biological_processimmune response
J0007155biological_processcell adhesion
J0007165biological_processsignal transduction
J0007186biological_processG protein-coupled receptor signaling pathway
J0007411biological_processaxon guidance
J0008009molecular_functionchemokine activity
J0008015biological_processblood circulation
J0008064biological_processregulation of actin polymerization or depolymerization
J0008083molecular_functiongrowth factor activity
J0008284biological_processpositive regulation of cell population proliferation
J0008344biological_processadult locomotory behavior
J0009612biological_processresponse to mechanical stimulus
J0009615biological_processresponse to virus
J0009897cellular_componentexternal side of plasma membrane
J0022029biological_processtelencephalon cell migration
J0030335biological_processpositive regulation of cell migration
J0031100biological_processanimal organ regeneration
J0033603biological_processpositive regulation of dopamine secretion
J0033622biological_processintegrin activation
J0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
J0038160biological_processCXCL12-activated CXCR4 signaling pathway
J0042379molecular_functionchemokine receptor binding
J0043434biological_processresponse to peptide hormone
J0045236molecular_functionCXCR chemokine receptor binding
J0045666biological_processpositive regulation of neuron differentiation
J0045785biological_processpositive regulation of cell adhesion
J0048842biological_processpositive regulation of axon extension involved in axon guidance
J0050930biological_processinduction of positive chemotaxis
J0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
J0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
J0051924biological_processregulation of calcium ion transport
J0060326biological_processcell chemotaxis
J0062023cellular_componentcollagen-containing extracellular matrix
J0070062cellular_componentextracellular exosome
J0070098biological_processchemokine-mediated signaling pathway
J0090026biological_processpositive regulation of monocyte chemotaxis
J0090280biological_processpositive regulation of calcium ion import
J1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
J1903237biological_processnegative regulation of leukocyte tethering or rolling
J1904018biological_processpositive regulation of vasculature development
J1990478biological_processresponse to ultrasound
J1990869biological_processcellular response to chemokine
J2000406biological_processpositive regulation of T cell migration
J2000669biological_processnegative regulation of dendritic cell apoptotic process
R0001618molecular_functionvirus receptor activity
R0001666biological_processresponse to hypoxia
R0001764biological_processneuron migration
R0002064biological_processepithelial cell development
R0002407biological_processdendritic cell chemotaxis
R0003779molecular_functionactin binding
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005764cellular_componentlysosome
R0005768cellular_componentendosome
R0005769cellular_componentearly endosome
R0005770cellular_componentlate endosome
R0005886cellular_componentplasma membrane
R0006915biological_processapoptotic process
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0007186biological_processG protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007420biological_processbrain development
R0008038biological_processneuron recognition
R0009615biological_processresponse to virus
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0014070biological_processresponse to organic cyclic compound
R0014823biological_processresponse to activity
R0015026molecular_functioncoreceptor activity
R0016477biological_processcell migration
R0016493molecular_functionC-C chemokine receptor activity
R0016494molecular_functionC-X-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019957molecular_functionC-C chemokine binding
R0022008biological_processneurogenesis
R0022029biological_processtelencephalon cell migration
R0030155biological_processregulation of cell adhesion
R0030335biological_processpositive regulation of cell migration
R0031252cellular_componentcell leading edge
R0031410cellular_componentcytoplasmic vesicle
R0031625molecular_functionubiquitin protein ligase binding
R0032027molecular_functionmyosin light chain binding
R0032991cellular_componentprotein-containing complex
R0035470biological_processpositive regulation of vascular wound healing
R0036094molecular_functionsmall molecule binding
R0038147molecular_functionC-X-C motif chemokine 12 receptor activity
R0038160biological_processCXCL12-activated CXCR4 signaling pathway
R0043067biological_processregulation of programmed cell death
R0043130molecular_functionubiquitin binding
R0043217biological_processmyelin maintenance
R0045446biological_processendothelial cell differentiation
R0046718biological_processsymbiont entry into host cell
R0048714biological_processpositive regulation of oligodendrocyte differentiation
R0050769biological_processpositive regulation of neurogenesis
R0050792biological_processregulation of viral process
R0050920biological_processregulation of chemotaxis
R0050921biological_processpositive regulation of chemotaxis
R0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
R0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
R0051924biological_processregulation of calcium ion transport
R0060048biological_processcardiac muscle contraction
R0060326biological_processcell chemotaxis
R0061154biological_processendothelial tube morphogenesis
R0070062cellular_componentextracellular exosome
R0070098biological_processchemokine-mediated signaling pathway
R0070161cellular_componentanchoring junction
R0071345biological_processcellular response to cytokine stimulus
R0071417biological_processcellular response to organonitrogen compound
R0071466biological_processcellular response to xenobiotic stimulus
R0120162biological_processpositive regulation of cold-induced thermogenesis
R1901327biological_processresponse to tacrolimus
R1903861biological_processpositive regulation of dendrite extension
R1904018biological_processpositive regulation of vasculature development
R1905322biological_processpositive regulation of mesenchymal stem cell migration
R1990478biological_processresponse to ultrasound
R2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI
ChainResidueDetails
RSER122-ILE138

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
JARG20
JARG41
JGLN48
JLYS64

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Important for integrin interaction and activation => ECO:0000269|PubMed:29301984
ChainResidueDetails
JLYS24
JLYS27
JLYS43
RALA303-SER352

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Important for dimer formation
ChainResidueDetails
JHIS25

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ALEU175
RALA175-TRP195
RASP262-LYS282

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
AASP200

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ASER326

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG178

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
AGLN204

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
ACYS351

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
ACYS3

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Sulfotyrosine; partial => ECO:0000269|PubMed:18834145
ChainResidueDetails
RTYR7
RTYR12

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:12034737, ECO:0000269|PubMed:16725153, ECO:0000269|PubMed:18834145
ChainResidueDetails
RTYR21

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
RSER319
RSER348

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20048153, ECO:0007744|PubMed:23186163
ChainResidueDetails
RSER321

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC and GRK6 => ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:20048153, ECO:0007744|PubMed:23186163
ChainResidueDetails
RSER324
RSER325

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: Phosphoserine; by GRK6 => ECO:0000269|PubMed:20048153
ChainResidueDetails
RSER330
RSER339

site_idSWS_FT_FI18
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20048153
ChainResidueDetails
RSER351

site_idSWS_FT_FI19
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10756055
ChainResidueDetails
RASN11

site_idSWS_FT_FI20
Number of Residues1
DetailsCARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:12034737
ChainResidueDetails
RSER18

site_idSWS_FT_FI21
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN176

site_idSWS_FT_FI22
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:28978524
ChainResidueDetails
RLYS331

219515

PDB entries from 2024-05-08

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