8TE1
Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DlVigGsPCnDLS |
| Chain | Residue | Details |
| A | ASP702-SER714 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018 |
| Chain | Residue | Details |
| A | CYS710 | |
| B | CYS710 | |
| C | CYS710 | |
| E | CYS710 | |
| H | CYS710 | |
| F | CYS710 | |
| D | CYS710 | |
| G | CYS710 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17713477, ECO:0007744|PDB:2QRV |
| Chain | Residue | Details |
| A | ASP641 | |
| C | GLU664 | |
| C | ASP686 | |
| C | ARG891 | |
| E | ASP641 | |
| E | GLU664 | |
| E | ASP686 | |
| E | ARG891 | |
| H | ASP641 | |
| H | GLU664 | |
| H | ASP686 | |
| A | GLU664 | |
| H | ARG891 | |
| F | ASP641 | |
| F | GLU664 | |
| F | ASP686 | |
| F | ARG891 | |
| D | ASP641 | |
| D | GLU664 | |
| D | ASP686 | |
| D | ARG891 | |
| G | ASP641 | |
| A | ASP686 | |
| G | GLU664 | |
| G | ASP686 | |
| G | ARG891 | |
| A | ARG891 | |
| B | ASP641 | |
| B | GLU664 | |
| B | ASP686 | |
| B | ARG891 | |
| C | ASP641 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: S-methylcysteine; by autocatalysis => ECO:0000250|UniProtKB:O88508 |
| Chain | Residue | Details |
| A | CYS710 | |
| B | CYS710 | |
| C | CYS710 | |
| E | CYS710 | |
| H | CYS710 | |
| F | CYS710 | |
| D | CYS710 | |
| G | CYS710 |
