8TA5
Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005247 | molecular_function | voltage-gated chloride channel activity |
A | 0005254 | molecular_function | chloride channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006821 | biological_process | chloride transport |
A | 0006911 | biological_process | phagocytosis, engulfment |
A | 0016323 | cellular_component | basolateral plasma membrane |
A | 0030324 | biological_process | lung development |
A | 0030425 | cellular_component | dendrite |
A | 0032347 | biological_process | regulation of aldosterone biosynthetic process |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0034707 | cellular_component | chloride channel complex |
A | 0043204 | cellular_component | perikaryon |
A | 0043209 | cellular_component | myelin sheath |
A | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
A | 0060041 | biological_process | retina development in camera-type eye |
A | 0060689 | biological_process | cell differentiation involved in salivary gland development |
A | 0090425 | biological_process | acinar cell differentiation |
A | 0097450 | cellular_component | astrocyte end-foot |
A | 1902476 | biological_process | chloride transmembrane transport |
B | 0005247 | molecular_function | voltage-gated chloride channel activity |
B | 0005254 | molecular_function | chloride channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006821 | biological_process | chloride transport |
B | 0006911 | biological_process | phagocytosis, engulfment |
B | 0016323 | cellular_component | basolateral plasma membrane |
B | 0030324 | biological_process | lung development |
B | 0030425 | cellular_component | dendrite |
B | 0032347 | biological_process | regulation of aldosterone biosynthetic process |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0034707 | cellular_component | chloride channel complex |
B | 0043204 | cellular_component | perikaryon |
B | 0043209 | cellular_component | myelin sheath |
B | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
B | 0060041 | biological_process | retina development in camera-type eye |
B | 0060689 | biological_process | cell differentiation involved in salivary gland development |
B | 0090425 | biological_process | acinar cell differentiation |
B | 0097450 | cellular_component | astrocyte end-foot |
B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 868 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
Chain | Residue | Details |
A | ALA2-VAL87 | |
A | GLN549-GLN898 | |
B | ALA2-VAL87 | |
B | GLN549-GLN898 |
site_id | SWS_FT_FI2 |
Number of Residues | 442 |
Details | TRANSMEM: Helical => ECO:0000250 |
Chain | Residue | Details |
A | GLY88-TRP121 | |
A | ILE531-LEU548 | |
B | GLY88-TRP121 | |
B | ILE130-LEU155 | |
B | LEU180-SER198 | |
B | GLU205-LEU223 | |
B | TYR275-TRP295 | |
B | LEU321-MET349 | |
B | PHE358-LEU377 | |
B | ALA429-ALA449 | |
B | GLY457-TRP480 | |
A | ILE130-LEU155 | |
B | ILE531-LEU548 | |
A | LEU180-SER198 | |
A | GLU205-LEU223 | |
A | TYR275-TRP295 | |
A | LEU321-MET349 | |
A | PHE358-LEU377 | |
A | ALA429-ALA449 | |
A | GLY457-TRP480 |
site_id | SWS_FT_FI3 |
Number of Residues | 14 |
Details | INTRAMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | ILE164-LEU171 | |
B | ILE164-LEU171 |
site_id | SWS_FT_FI4 |
Number of Residues | 90 |
Details | INTRAMEM: Helical => ECO:0000250 |
Chain | Residue | Details |
A | MET239-CYS251 | |
A | PRO255-ILE263 | |
A | GLY497-VAL511 | |
A | THR514-THR525 | |
B | MET239-CYS251 | |
B | PRO255-ILE263 | |
B | GLY497-VAL511 | |
B | THR514-THR525 |
site_id | SWS_FT_FI5 |
Number of Residues | 10 |
Details | INTRAMEM: Note=Loop between two helices => ECO:0000250 |
Chain | Residue | Details |
A | THR512-HIS513 | |
A | GLY526-HIS530 | |
B | THR512-HIS513 | |
B | GLY526-HIS530 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER162 | |
A | PHE459 | |
A | TYR553 | |
B | SER162 | |
B | PHE459 | |
B | TYR553 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9R0A1 |
Chain | Residue | Details |
A | THR20 | |
B | THR20 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER712 | |
B | SER712 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P35525 |
Chain | Residue | Details |
A | SER758 | |
B | SER758 |