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8T1J

Uncrosslinked nNOS-CaM oxygenase homodimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001917cellular_componentphotoreceptor inner segment
A0002028biological_processregulation of sodium ion transport
A0004517molecular_functionnitric-oxide synthase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006527biological_processarginine catabolic process
A0006809biological_processnitric oxide biosynthetic process
A0006813biological_processpotassium ion transport
A0006816biological_processcalcium ion transport
A0006941biological_processstriated muscle contraction
A0007263biological_processnitric oxide mediated signal transduction
A0007565biological_processfemale pregnancy
A0008270molecular_functionzinc ion binding
A0008285biological_processnegative regulation of cell population proliferation
A0009408biological_processresponse to heat
A0009725biological_processresponse to hormone
A0010181molecular_functionFMN binding
A0010243biological_processresponse to organonitrogen compound
A0010288biological_processresponse to lead ion
A0014069cellular_componentpostsynaptic density
A0014070biological_processresponse to organic cyclic compound
A0014823biological_processresponse to activity
A0016491molecular_functionoxidoreductase activity
A0016529cellular_componentsarcoplasmic reticulum
A0017080molecular_functionsodium channel regulator activity
A0018119biological_processpeptidyl-cysteine S-nitrosylation
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0030018cellular_componentZ disc
A0030141cellular_componentsecretory granule
A0030315cellular_componentT-tubule
A0030425cellular_componentdendrite
A0031667biological_processresponse to nutrient levels
A0031965cellular_componentnuclear membrane
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0033017cellular_componentsarcoplasmic reticulum membrane
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0033197biological_processresponse to vitamin E
A0033555biological_processmulticellular organismal response to stress
A0034760biological_processnegative regulation of iron ion transmembrane transport
A0035094biological_processresponse to nicotine
A0038060biological_processnitric oxide-cGMP-mediated signaling
A0042178biological_processxenobiotic catabolic process
A0042311biological_processvasodilation
A0042383cellular_componentsarcolemma
A0042582cellular_componentazurophil granule
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043066biological_processnegative regulation of apoptotic process
A0043197cellular_componentdendritic spine
A0043267biological_processnegative regulation of potassium ion transport
A0043434biological_processresponse to peptide hormone
A0043524biological_processnegative regulation of neuron apoptotic process
A0043627biological_processresponse to estrogen
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0045121cellular_componentmembrane raft
A0045184biological_processestablishment of protein localization
A0045202cellular_componentsynapse
A0045471biological_processresponse to ethanol
A0045776biological_processnegative regulation of blood pressure
A0045893biological_processpositive regulation of DNA-templated transcription
A0045906biological_processnegative regulation of vasoconstriction
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046209biological_processnitric oxide metabolic process
A0046676biological_processnegative regulation of insulin secretion
A0046870molecular_functioncadmium ion binding
A0046872molecular_functionmetal ion binding
A0048148biological_processbehavioral response to cocaine
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0050767biological_processregulation of neurogenesis
A0051117molecular_functionATPase binding
A0051219molecular_functionphosphoprotein binding
A0051481biological_processnegative regulation of cytosolic calcium ion concentration
A0051612biological_processnegative regulation of serotonin uptake
A0051649biological_processestablishment of localization in cell
A0051926biological_processnegative regulation of calcium ion transport
A0060078biological_processregulation of postsynaptic membrane potential
A0061875biological_processnegative regulation of hepatic stellate cell contraction
A0070402molecular_functionNADPH binding
A0071260biological_processcellular response to mechanical stimulus
A0071363biological_processcellular response to growth factor stimulus
A0071731biological_processresponse to nitric oxide
A0071872biological_processcellular response to epinephrine stimulus
A0071879biological_processpositive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
A0071944cellular_componentcell periphery
A0097110molecular_functionscaffold protein binding
A0098735biological_processpositive regulation of the force of heart contraction
A0098924biological_processretrograde trans-synaptic signaling by nitric oxide
A0098978cellular_componentglutamatergic synapse
A0099091cellular_componentpostsynaptic specialization, intracellular component
A0099092cellular_componentpostsynaptic density, intracellular component
A0099163biological_processsynaptic signaling by nitric oxide
A0106071biological_processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1902307biological_processpositive regulation of sodium ion transmembrane transport
B0001666biological_processresponse to hypoxia
B0001917cellular_componentphotoreceptor inner segment
B0002028biological_processregulation of sodium ion transport
B0004517molecular_functionnitric-oxide synthase activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0006527biological_processarginine catabolic process
B0006809biological_processnitric oxide biosynthetic process
B0006813biological_processpotassium ion transport
B0006816biological_processcalcium ion transport
B0006941biological_processstriated muscle contraction
B0007263biological_processnitric oxide mediated signal transduction
B0007565biological_processfemale pregnancy
B0008270molecular_functionzinc ion binding
B0008285biological_processnegative regulation of cell population proliferation
B0009408biological_processresponse to heat
B0009725biological_processresponse to hormone
B0010181molecular_functionFMN binding
B0010243biological_processresponse to organonitrogen compound
B0010288biological_processresponse to lead ion
B0014069cellular_componentpostsynaptic density
B0014070biological_processresponse to organic cyclic compound
B0014823biological_processresponse to activity
B0016491molecular_functionoxidoreductase activity
B0016529cellular_componentsarcoplasmic reticulum
B0017080molecular_functionsodium channel regulator activity
B0018119biological_processpeptidyl-cysteine S-nitrosylation
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0030018cellular_componentZ disc
B0030141cellular_componentsecretory granule
B0030315cellular_componentT-tubule
B0030425cellular_componentdendrite
B0031667biological_processresponse to nutrient levels
B0031965cellular_componentnuclear membrane
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0033017cellular_componentsarcoplasmic reticulum membrane
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0033197biological_processresponse to vitamin E
B0033555biological_processmulticellular organismal response to stress
B0034760biological_processnegative regulation of iron ion transmembrane transport
B0035094biological_processresponse to nicotine
B0038060biological_processnitric oxide-cGMP-mediated signaling
B0042178biological_processxenobiotic catabolic process
B0042311biological_processvasodilation
B0042383cellular_componentsarcolemma
B0042582cellular_componentazurophil granule
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043066biological_processnegative regulation of apoptotic process
B0043197cellular_componentdendritic spine
B0043267biological_processnegative regulation of potassium ion transport
B0043434biological_processresponse to peptide hormone
B0043524biological_processnegative regulation of neuron apoptotic process
B0043627biological_processresponse to estrogen
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0045121cellular_componentmembrane raft
B0045184biological_processestablishment of protein localization
B0045202cellular_componentsynapse
B0045471biological_processresponse to ethanol
B0045776biological_processnegative regulation of blood pressure
B0045893biological_processpositive regulation of DNA-templated transcription
B0045906biological_processnegative regulation of vasoconstriction
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046209biological_processnitric oxide metabolic process
B0046676biological_processnegative regulation of insulin secretion
B0046870molecular_functioncadmium ion binding
B0046872molecular_functionmetal ion binding
B0048148biological_processbehavioral response to cocaine
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0050767biological_processregulation of neurogenesis
B0051117molecular_functionATPase binding
B0051219molecular_functionphosphoprotein binding
B0051481biological_processnegative regulation of cytosolic calcium ion concentration
B0051612biological_processnegative regulation of serotonin uptake
B0051649biological_processestablishment of localization in cell
B0051926biological_processnegative regulation of calcium ion transport
B0060078biological_processregulation of postsynaptic membrane potential
B0061875biological_processnegative regulation of hepatic stellate cell contraction
B0070402molecular_functionNADPH binding
B0071260biological_processcellular response to mechanical stimulus
B0071363biological_processcellular response to growth factor stimulus
B0071731biological_processresponse to nitric oxide
B0071872biological_processcellular response to epinephrine stimulus
B0071879biological_processpositive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
B0071944cellular_componentcell periphery
B0097110molecular_functionscaffold protein binding
B0098735biological_processpositive regulation of the force of heart contraction
B0098924biological_processretrograde trans-synaptic signaling by nitric oxide
B0098978cellular_componentglutamatergic synapse
B0099091cellular_componentpostsynaptic specialization, intracellular component
B0099092cellular_componentpostsynaptic density, intracellular component
B0099163biological_processsynaptic signaling by nitric oxide
B0106071biological_processpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
B1900273biological_processpositive regulation of long-term synaptic potentiation
B1902307biological_processpositive regulation of sodium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCVGRIqW
ChainResidueDetails
AARG414-TRP421

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P29475
ChainResidueDetails
ASER334
AGLN478
ATRP587
ATYR588
AGLU592
AVAL677
ATRP678
APHE691
ATYR706
BSER334
BGLN478
BTRP587
BTYR588
BGLU592
BVAL677
BTRP678
BPHE691
BTYR706

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:P29475
ChainResidueDetails
ACYS415
BCYS415

site_idSWS_FT_FI3
Number of Residues42
DetailsBINDING: BINDING => ECO:0000269|PubMed:15208315, ECO:0007744|PDB:1TLL
ChainResidueDetails
ATHR761
AGLU762
ATHR763
ALYS765
ASER766
ASER807
ATHR808
AGLY812
ASER886
AHIS891
ACYS893
AGLU919
AGLN923
AHIS1032
ATYR1175
ASER1196
ATYR1197
AARG1284
ALYS1320
ATHR1398
AARG1400
BTHR761
BGLU762
BTHR763
BLYS765
BSER766
BSER807
BTHR808
BGLY812
BSER886
BHIS891
BCYS893
BGLU919
BGLN923
BHIS1032
BTYR1175
BSER1196
BTYR1197
BARG1284
BLYS1320
BTHR1398
BARG1400

site_idSWS_FT_FI4
Number of Residues28
DetailsBINDING: BINDING => ECO:0000269|PubMed:11473123, ECO:0000269|PubMed:15208315, ECO:0007744|PDB:1F20, ECO:0007744|PDB:1TLL
ChainResidueDetails
AARG1010
AARG1173
ATYR1174
ASER1176
ATHR1191
AALA1193
AVAL1210
ACYS1211
ASER1212
ATHR1251
ASER1313
AARG1314
ATYR1322
AGLN1324
BARG1010
BARG1173
BTYR1174
BSER1176
BTHR1191
BALA1193
BVAL1210
BCYS1211
BSER1212
BTHR1251
BSER1313
BARG1314
BTYR1322
BGLN1324

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11473123, ECO:0007744|PDB:1F20
ChainResidueDetails
AASP1357
BASP1357

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0J4
ChainResidueDetails
ASER280
ASER857
BSER280
BSER857

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER847
ASER858
BSER847
BSER858

219869

PDB entries from 2024-05-15

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