8SG5

Cytochrome P450 (CYP) 3A5 crystallized with clotrimazole

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008401	molecular_function	retinoic acid 4-hydroxylase activity
A	0009822	biological_process	alkaloid catabolic process
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046222	biological_process	aflatoxin metabolic process
A	0046872	molecular_function	metal ion binding
A	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
A	0070330	molecular_function	aromatase activity
A	0070989	biological_process	oxidative demethylation
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
B	0002933	biological_process	lipid hydroxylation
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008210	biological_process	estrogen metabolic process
B	0008401	molecular_function	retinoic acid 4-hydroxylase activity
B	0009822	biological_process	alkaloid catabolic process
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0042178	biological_process	xenobiotic catabolic process
B	0042572	biological_process	retinol metabolic process
B	0042573	biological_process	retinoic acid metabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046222	biological_process	aflatoxin metabolic process
B	0046872	molecular_function	metal ion binding
B	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
B	0070330	molecular_function	aromatase activity
B	0070989	biological_process	oxidative demethylation
B	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
C	0002933	biological_process	lipid hydroxylation
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008210	biological_process	estrogen metabolic process
C	0008401	molecular_function	retinoic acid 4-hydroxylase activity
C	0009822	biological_process	alkaloid catabolic process
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0042178	biological_process	xenobiotic catabolic process
C	0042572	biological_process	retinol metabolic process
C	0042573	biological_process	retinoic acid metabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046222	biological_process	aflatoxin metabolic process
C	0046872	molecular_function	metal ion binding
C	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
C	0070330	molecular_function	aromatase activity
C	0070989	biological_process	oxidative demethylation
C	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
D	0002933	biological_process	lipid hydroxylation
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006805	biological_process	xenobiotic metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008210	biological_process	estrogen metabolic process
D	0008401	molecular_function	retinoic acid 4-hydroxylase activity
D	0009822	biological_process	alkaloid catabolic process
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0042178	biological_process	xenobiotic catabolic process
D	0042572	biological_process	retinol metabolic process
D	0042573	biological_process	retinoic acid metabolic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046222	biological_process	aflatoxin metabolic process
D	0046872	molecular_function	metal ion binding
D	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
D	0070330	molecular_function	aromatase activity
D	0070989	biological_process	oxidative demethylation
D	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
E	0002933	biological_process	lipid hydroxylation
E	0004497	molecular_function	monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006805	biological_process	xenobiotic metabolic process
E	0008202	biological_process	steroid metabolic process
E	0008210	biological_process	estrogen metabolic process
E	0008401	molecular_function	retinoic acid 4-hydroxylase activity
E	0009822	biological_process	alkaloid catabolic process
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
E	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0042178	biological_process	xenobiotic catabolic process
E	0042572	biological_process	retinol metabolic process
E	0042573	biological_process	retinoic acid metabolic process
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0046222	biological_process	aflatoxin metabolic process
E	0046872	molecular_function	metal ion binding
E	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
E	0070330	molecular_function	aromatase activity
E	0070989	biological_process	oxidative demethylation
E	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
F	0002933	biological_process	lipid hydroxylation
F	0004497	molecular_function	monooxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006805	biological_process	xenobiotic metabolic process
F	0008202	biological_process	steroid metabolic process
F	0008210	biological_process	estrogen metabolic process
F	0008401	molecular_function	retinoic acid 4-hydroxylase activity
F	0009822	biological_process	alkaloid catabolic process
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
F	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0042178	biological_process	xenobiotic catabolic process
F	0042572	biological_process	retinol metabolic process
F	0042573	biological_process	retinoic acid metabolic process
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0046222	biological_process	aflatoxin metabolic process
F	0046872	molecular_function	metal ion binding
F	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
F	0070330	molecular_function	aromatase activity
F	0070989	biological_process	oxidative demethylation
F	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
G	0002933	biological_process	lipid hydroxylation
G	0004497	molecular_function	monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006805	biological_process	xenobiotic metabolic process
G	0008202	biological_process	steroid metabolic process
G	0008210	biological_process	estrogen metabolic process
G	0008401	molecular_function	retinoic acid 4-hydroxylase activity
G	0009822	biological_process	alkaloid catabolic process
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
G	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0042178	biological_process	xenobiotic catabolic process
G	0042572	biological_process	retinol metabolic process
G	0042573	biological_process	retinoic acid metabolic process
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0046222	biological_process	aflatoxin metabolic process
G	0046872	molecular_function	metal ion binding
G	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
G	0070330	molecular_function	aromatase activity
G	0070989	biological_process	oxidative demethylation
G	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
H	0002933	biological_process	lipid hydroxylation
H	0004497	molecular_function	monooxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006805	biological_process	xenobiotic metabolic process
H	0008202	biological_process	steroid metabolic process
H	0008210	biological_process	estrogen metabolic process
H	0008401	molecular_function	retinoic acid 4-hydroxylase activity
H	0009822	biological_process	alkaloid catabolic process
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
H	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0042178	biological_process	xenobiotic catabolic process
H	0042572	biological_process	retinol metabolic process
H	0042573	biological_process	retinoic acid metabolic process
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0046222	biological_process	aflatoxin metabolic process
H	0046872	molecular_function	metal ion binding
H	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
H	0070330	molecular_function	aromatase activity
H	0070989	biological_process	oxidative demethylation
H	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGtGPRNCIG

Chain	Residue	Details
A	PHE434-GLY443

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: axial binding residue

Chain	Residue	Details
A	CYS441
B	CYS441
C	CYS441
D	CYS441
E	CYS441
F	CYS441
G	CYS441
H	CYS441

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