8RQ3
Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in an autoinhibited state (nucleotide-free)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0007565 | biological_process | female pregnancy |
| A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| A | 0008559 | molecular_function | ABC-type xenobiotic transporter activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009986 | cellular_component | cell surface |
| A | 0010629 | biological_process | negative regulation of gene expression |
| A | 0014070 | biological_process | response to organic cyclic compound |
| A | 0015127 | molecular_function | bilirubin transmembrane transporter activity |
| A | 0015431 | molecular_function | ABC-type glutathione S-conjugate transporter activity |
| A | 0015694 | biological_process | mercury ion transport |
| A | 0015711 | biological_process | organic anion transport |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015722 | biological_process | canalicular bile acid transport |
| A | 0015723 | biological_process | bilirubin transport |
| A | 0015732 | biological_process | prostaglandin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016999 | biological_process | antibiotic metabolic process |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030644 | biological_process | intracellular chloride ion homeostasis |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0032355 | biological_process | response to estradiol |
| A | 0032496 | biological_process | response to lipopolysaccharide |
| A | 0033762 | biological_process | response to glucagon |
| A | 0038183 | biological_process | bile acid signaling pathway |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0043627 | biological_process | response to estrogen |
| A | 0046581 | cellular_component | intercellular canaliculus |
| A | 0046618 | biological_process | xenobiotic export from cell |
| A | 0046685 | biological_process | response to arsenic-containing substance |
| A | 0046691 | cellular_component | intracellular canaliculus |
| A | 0048545 | biological_process | response to steroid hormone |
| A | 0050787 | biological_process | detoxification of mercury ion |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070327 | biological_process | thyroid hormone transport |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0071222 | biological_process | cellular response to lipopolysaccharide |
| A | 0071347 | biological_process | cellular response to interleukin-1 |
| A | 0071354 | biological_process | cellular response to interleukin-6 |
| A | 0071356 | biological_process | cellular response to tumor necrosis factor |
| A | 0071466 | biological_process | cellular response to xenobiotic stimulus |
| A | 0071549 | biological_process | cellular response to dexamethasone stimulus |
| A | 0071716 | biological_process | leukotriene transport |
| A | 0097327 | biological_process | response to antineoplastic agent |
| A | 0120188 | biological_process | regulation of bile acid secretion |
| A | 1901086 | biological_process | benzylpenicillin metabolic process |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| A | 1990962 | biological_process | xenobiotic transport across blood-brain barrier |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRVSLARAA |
| Chain | Residue | Details |
| A | LEU757-ALA771 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 135 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-PHE26 | |
| A | ASP89-GLN92 | |
| A | GLN147-SER164 | |
| A | LEU331-GLY356 | |
| A | LEU455-PRO457 | |
| A | VAL562-ASN583 | |
| A | PHE989-ALA1029 | |
| A | ALA1115 | |
| A | LEU1229-THR1230 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLU27-LEU47 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1032 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR48-LYS67 | |
| A | LEU114-ARG125 | |
| A | PRO186-SER309 | |
| A | PHE378-TYR433 | |
| A | LYS479-SER540 | |
| A | SER605-LEU967 | |
| A | ALA1051-GLN1093 | |
| A | TYR1137-LEU1207 | |
| A | VAL1252-LEU1541 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLN68-GLU88 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ALA93-VAL113 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LYS126-PHE146 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | TYR165-GLY185 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LEU310-LEU330 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | TYR357-TYR377 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | MET434-GLU454 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | SER458-THR478 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LEU541-TYR561 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ILE584-VAL604 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLN968-ALA988 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLN1030-LYS1050 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | THR1094-MET1114 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | THR1116-PHE1136 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLU1208-THR1228 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=17 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLY1231-LEU1251 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY667 | |
| A | GLY1330 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | SER279 | |
| A | SER281 | |
| A | SER874 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q92887 |
| Chain | Residue | Details |
| A | SER922 | |
| A | SER926 | |
| A | SER1434 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN6 | |
| A | ASN1007 | |
| A | ASN1010 | |
| A | ASN1011 |
