8PS8

Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the enoyl reductase domain (FASam sample)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0046872	molecular_function	metal ion binding
G	0004312	molecular_function	fatty acid synthase activity
G	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
G	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
G	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0004321	molecular_function	fatty-acyl-CoA synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0005835	cellular_component	fatty acid synthase complex
G	0006633	biological_process	fatty acid biosynthetic process
G	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
G	0016409	molecular_function	palmitoyltransferase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0016787	molecular_function	hydrolase activity
G	0016829	molecular_function	lyase activity
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL

Chain	Residue	Details
A	LEU175-LEU190

---

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
A	GLY1296-VAL1312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For acetyltransferase activity => ECO:0000250

Chain	Residue	Details
G	SER274
A	HIS1542
A	HIS1583
B	CYS1305
B	HIS1542
B	HIS1583

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: For malonyltransferase activity => ECO:0000250

Chain	Residue	Details
G	SER1808
B	VAL1773
B	GLU1774
B	GLU1817
B	ARG1841
B	ILE1871
B	SER1872
B	HIS1873
A	VAL1773
A	GLU1774
A	GLU1817
A	ARG1841
A	ILE1871
A	SER1872
A	HIS1873
B	ASP1772

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
G	MET1
A	SER1808
B	TYR1798
B	SER1808

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
G	THR733
B	SER50

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
G	SER1121
B	SER180

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
G	LYS1364
B	SER523

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	SER958
A	SER1440
B	SER958
B	SER1440

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS37
B	LYS37

---