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8OVH

Crystal structure of O-acetyl-L-homoserine sulfhydrolase from Saccharomyces cerevisiae in complex with Pyridoxal-5'-phosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000103biological_processsulfate assimilation
A0003961molecular_functionO-acetylhomoserine aminocarboxypropyltransferase activity
A0004124molecular_functioncysteine synthase activity
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006520biological_processamino acid metabolic process
A0006535biological_processcysteine biosynthetic process from serine
A0006555biological_processmethionine metabolic process
A0009086biological_processmethionine biosynthetic process
A0016740molecular_functiontransferase activity
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
A0019344biological_processcysteine biosynthetic process
A0019346biological_processtranssulfuration
A0030170molecular_functionpyridoxal phosphate binding
A0051009molecular_functionO-acetylhomoserine sulfhydrylase activity
A0071266biological_process'de novo' L-methionine biosynthetic process
A0071269biological_processL-homocysteine biosynthetic process
B0000103biological_processsulfate assimilation
B0003961molecular_functionO-acetylhomoserine aminocarboxypropyltransferase activity
B0004124molecular_functioncysteine synthase activity
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006520biological_processamino acid metabolic process
B0006535biological_processcysteine biosynthetic process from serine
B0006555biological_processmethionine metabolic process
B0009086biological_processmethionine biosynthetic process
B0016740molecular_functiontransferase activity
B0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
B0019344biological_processcysteine biosynthetic process
B0019346biological_processtranssulfuration
B0030170molecular_functionpyridoxal phosphate binding
B0051009molecular_functionO-acetylhomoserine sulfhydrylase activity
B0071266biological_process'de novo' L-methionine biosynthetic process
B0071269biological_processL-homocysteine biosynthetic process
C0000103biological_processsulfate assimilation
C0003961molecular_functionO-acetylhomoserine aminocarboxypropyltransferase activity
C0004124molecular_functioncysteine synthase activity
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006520biological_processamino acid metabolic process
C0006535biological_processcysteine biosynthetic process from serine
C0006555biological_processmethionine metabolic process
C0009086biological_processmethionine biosynthetic process
C0016740molecular_functiontransferase activity
C0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
C0019344biological_processcysteine biosynthetic process
C0019346biological_processtranssulfuration
C0030170molecular_functionpyridoxal phosphate binding
C0051009molecular_functionO-acetylhomoserine sulfhydrylase activity
C0071266biological_process'de novo' L-methionine biosynthetic process
C0071269biological_processL-homocysteine biosynthetic process
D0000103biological_processsulfate assimilation
D0003961molecular_functionO-acetylhomoserine aminocarboxypropyltransferase activity
D0004124molecular_functioncysteine synthase activity
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006520biological_processamino acid metabolic process
D0006535biological_processcysteine biosynthetic process from serine
D0006555biological_processmethionine metabolic process
D0009086biological_processmethionine biosynthetic process
D0016740molecular_functiontransferase activity
D0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
D0019344biological_processcysteine biosynthetic process
D0019346biological_processtranssulfuration
D0030170molecular_functionpyridoxal phosphate binding
D0051009molecular_functionO-acetylhomoserine sulfhydrylase activity
D0071266biological_process'de novo' L-methionine biosynthetic process
D0071269biological_processL-homocysteine biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00868
Number of Residues15
DetailsCYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIvthSATKWIgGHG
ChainResidueDetails
AASP201-GLY215

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956
ChainResidueDetails
ASER44
BSER44
CSER44
DSER44

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250|UniProtKB:P06721
ChainResidueDetails
ALYS209
BLYS209
CLYS209
DLYS209

site_idSWS_FT_FI3
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ALYS160
BLYS160
CLYS160
DLYS160

219869

PDB entries from 2024-05-15

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