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8OPQ

Structure of Human Solute Carrier 26 family member A6 (SLC26A6) anion transporter in an inward-facing state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005254molecular_functionchloride channel activity
A0005452molecular_functionsolute:inorganic anion antiporter activity
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0008271molecular_functionsecondary active sulfate transmembrane transporter activity
A0008272biological_processsulfate transport
A0012506cellular_componentvesicle membrane
A0015106molecular_functionbicarbonate transmembrane transporter activity
A0015108molecular_functionchloride transmembrane transporter activity
A0015116molecular_functionsulfate transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015499molecular_functionformate transmembrane transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015701biological_processbicarbonate transport
A0015724biological_processformate transport
A0015797biological_processmannitol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016740molecular_functiontransferase activity
A0019531molecular_functionoxalate transmembrane transporter activity
A0019532biological_processoxalate transport
A0030165molecular_functionPDZ domain binding
A0030321biological_processtransepithelial chloride transport
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031526cellular_componentbrush border membrane
A0031982cellular_componentvesicle
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0042045biological_processepithelial fluid transport
A0044849biological_processestrous cycle
A0046724biological_processoxalic acid secretion
A0048240biological_processsperm capacitation
A0050892biological_processintestinal absorption
A0051453biological_processregulation of intracellular pH
A0051454biological_processintracellular pH elevation
A0051649biological_processestablishment of localization in cell
A0055085biological_processtransmembrane transport
A0070633biological_processtransepithelial transport
A0071320biological_processcellular response to cAMP
A0071332biological_processcellular response to fructose stimulus
A0071346biological_processcellular response to type II interferon
A0097225cellular_componentsperm midpiece
A0140900molecular_functionchloride:bicarbonate antiporter activity
A1902358biological_processsulfate transmembrane transport
A1902476biological_processchloride transmembrane transport
A2001150biological_processpositive regulation of dipeptide transmembrane transport
B0005254molecular_functionchloride channel activity
B0005452molecular_functionsolute:inorganic anion antiporter activity
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0008271molecular_functionsecondary active sulfate transmembrane transporter activity
B0008272biological_processsulfate transport
B0012506cellular_componentvesicle membrane
B0015106molecular_functionbicarbonate transmembrane transporter activity
B0015108molecular_functionchloride transmembrane transporter activity
B0015116molecular_functionsulfate transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0015499molecular_functionformate transmembrane transporter activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015701biological_processbicarbonate transport
B0015724biological_processformate transport
B0015797biological_processmannitol transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016740molecular_functiontransferase activity
B0019531molecular_functionoxalate transmembrane transporter activity
B0019532biological_processoxalate transport
B0030165molecular_functionPDZ domain binding
B0030321biological_processtransepithelial chloride transport
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031526cellular_componentbrush border membrane
B0031982cellular_componentvesicle
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0042045biological_processepithelial fluid transport
B0044849biological_processestrous cycle
B0046724biological_processoxalic acid secretion
B0048240biological_processsperm capacitation
B0050892biological_processintestinal absorption
B0051453biological_processregulation of intracellular pH
B0051454biological_processintracellular pH elevation
B0051649biological_processestablishment of localization in cell
B0055085biological_processtransmembrane transport
B0070633biological_processtransepithelial transport
B0071320biological_processcellular response to cAMP
B0071332biological_processcellular response to fructose stimulus
B0071346biological_processcellular response to type II interferon
B0097225cellular_componentsperm midpiece
B0140900molecular_functionchloride:bicarbonate antiporter activity
B1902358biological_processsulfate transmembrane transport
B1902476biological_processchloride transmembrane transport
B2001150biological_processpositive regulation of dipeptide transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS01130
Number of Residues22
DetailsSLC26A SLC26A transporters signature. PvFGLYSSfypvFIYflfGTSR
ChainResidueDetails
APRO119-ARG140

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues320
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AGLY116-PHE136
ALEU187-VAL207
AVAL264-ASN284
APRO294-LEU314
AALA348-LEU368
ALEU380-CYS400
AVAL417-PHE437
AILE485-VAL505
BGLY116-PHE136
BLEU187-VAL207
BVAL264-ASN284
BPRO294-LEU314
BALA348-LEU368
BLEU380-CYS400
BVAL417-PHE437
BILE485-VAL505

site_idSWS_FT_FI2
Number of Residues226
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLY137-THR186
AASP285-MET293
AARG369-GLU379
AHIS438-THR484
BGLY137-THR186
BASP285-MET293
BARG369-GLU379
BHIS438-THR484

site_idSWS_FT_FI3
Number of Residues204
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ATHR208-LYS263
ALYS315-SER347
ASER401-GLN416
BTHR208-LYS263
BLYS315-SER347
BSER401-GLN416

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER616
AVAL755
BSER616
BVAL755

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231
ChainResidueDetails
APRO752
BPRO752

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc) asparagine => ECO:0000269|PubMed:27681177
ChainResidueDetails
AASN167
AASN172
BASN167
BASN172

219869

PDB entries from 2024-05-15

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