Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8JFL

PhK holoenzyme in active state, muscle isoform

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004689	molecular_function	phosphorylase kinase activity
A	0005516	molecular_function	calmodulin binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005964	cellular_component	phosphorylase kinase complex
A	0005977	biological_process	glycogen metabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0045819	biological_process	positive regulation of glycogen catabolic process
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005964	cellular_component	phosphorylase kinase complex
B	0005977	biological_process	glycogen metabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004689	molecular_function	phosphorylase kinase activity
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0005964	cellular_component	phosphorylase kinase complex
C	0005975	biological_process	carbohydrate metabolic process
C	0005977	biological_process	glycogen metabolic process
C	0019899	molecular_function	enzyme binding
C	0050321	molecular_function	tau-protein kinase activity
C	0106310	molecular_function	protein serine kinase activity
E	0004689	molecular_function	phosphorylase kinase activity
E	0005516	molecular_function	calmodulin binding
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005964	cellular_component	phosphorylase kinase complex
E	0005977	biological_process	glycogen metabolic process
E	0006091	biological_process	generation of precursor metabolites and energy
E	0045819	biological_process	positive regulation of glycogen catabolic process
F	0005515	molecular_function	protein binding
F	0005516	molecular_function	calmodulin binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005964	cellular_component	phosphorylase kinase complex
F	0005977	biological_process	glycogen metabolic process
F	0006091	biological_process	generation of precursor metabolites and energy
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004689	molecular_function	phosphorylase kinase activity
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0005964	cellular_component	phosphorylase kinase complex
G	0005975	biological_process	carbohydrate metabolic process
G	0005977	biological_process	glycogen metabolic process
G	0019899	molecular_function	enzyme binding
G	0050321	molecular_function	tau-protein kinase activity
G	0106310	molecular_function	protein serine kinase activity
I	0004689	molecular_function	phosphorylase kinase activity
I	0005516	molecular_function	calmodulin binding
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005964	cellular_component	phosphorylase kinase complex
I	0005977	biological_process	glycogen metabolic process
I	0006091	biological_process	generation of precursor metabolites and energy
I	0045819	biological_process	positive regulation of glycogen catabolic process
J	0005515	molecular_function	protein binding
J	0005516	molecular_function	calmodulin binding
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005964	cellular_component	phosphorylase kinase complex
J	0005977	biological_process	glycogen metabolic process
J	0006091	biological_process	generation of precursor metabolites and energy
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0004689	molecular_function	phosphorylase kinase activity
K	0005516	molecular_function	calmodulin binding
K	0005524	molecular_function	ATP binding
K	0005829	cellular_component	cytosol
K	0005964	cellular_component	phosphorylase kinase complex
K	0005975	biological_process	carbohydrate metabolic process
K	0005977	biological_process	glycogen metabolic process
K	0019899	molecular_function	enzyme binding
K	0050321	molecular_function	tau-protein kinase activity
K	0106310	molecular_function	protein serine kinase activity
M	0004689	molecular_function	phosphorylase kinase activity
M	0005516	molecular_function	calmodulin binding
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0005964	cellular_component	phosphorylase kinase complex
M	0005977	biological_process	glycogen metabolic process
M	0006091	biological_process	generation of precursor metabolites and energy
M	0045819	biological_process	positive regulation of glycogen catabolic process
N	0005515	molecular_function	protein binding
N	0005516	molecular_function	calmodulin binding
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005964	cellular_component	phosphorylase kinase complex
N	0005977	biological_process	glycogen metabolic process
N	0006091	biological_process	generation of precursor metabolites and energy
O	0004674	molecular_function	protein serine/threonine kinase activity
O	0004689	molecular_function	phosphorylase kinase activity
O	0005516	molecular_function	calmodulin binding
O	0005524	molecular_function	ATP binding
O	0005829	cellular_component	cytosol
O	0005964	cellular_component	phosphorylase kinase complex
O	0005975	biological_process	carbohydrate metabolic process
O	0005977	biological_process	glycogen metabolic process
O	0019899	molecular_function	enzyme binding
O	0050321	molecular_function	tau-protein kinase activity
O	0106310	molecular_function	protein serine kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGVSSVVRrCihkptsqe..........YAVK

Chain	Residue	Details
C	LEU26-LYS49

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILL

Chain	Residue	Details
C	ILE146-LEU158

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P12798

Chain	Residue	Details
B	ALA2
F	ALA2
J	ALA2
N	ALA2
M	SER629
M	SER1113
I	SER629
I	SER1113

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250\|UniProtKB:P12798

Chain	Residue	Details
B	SER12
F	SER12
J	SER12
N	SER12
O	LEU26
O	LYS49
K	LEU26
K	LYS49

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	SER27
F	SER27
J	SER27
N	SER27

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P12798

Chain	Residue	Details
B	SER701
F	SER701
J	SER701
N	SER701

site_id	SWS_FT_FI5
Number of Residues	4
Details	LIPID: S-farnesyl cysteine => ECO:0000250\|UniProtKB:P12798

Chain	Residue	Details
B	CYS1090
F	CYS1090
J	CYS1090
N	CYS1090
M	SER972
M	SER985
I	SER972
I	SER985

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250\|UniProtKB:P18688

Chain	Residue	Details
A	SER1007
E	SER1007
M	SER1007
I	SER1007

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000250\|UniProtKB:P18688

Chain	Residue	Details
A	SER1018
E	SER1018
M	SER1018
I	SER1018

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P18688

Chain	Residue	Details
A	SER1020
A	SER1023
E	SER1020
E	SER1023
M	SER1020
M	SER1023
I	SER1020
I	SER1023

site_id	SWS_FT_FI9
Number of Residues	4
Details	LIPID: S-farnesyl cysteine => ECO:0000250\|UniProtKB:P18688

Chain	Residue	Details
A	CYS1220
E	CYS1220
M	CYS1220
I	CYS1220

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)