8JBH

Substance P bound to active human neurokinin 3 receptor in complex with Gq

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0001750	cellular_component	photoreceptor outer segment
D	0001917	cellular_component	photoreceptor inner segment
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005834	cellular_component	heterotrimeric G-protein complex
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0008283	biological_process	cell population proliferation
D	0010659	biological_process	cardiac muscle cell apoptotic process
D	0030159	molecular_function	signaling receptor complex adaptor activity
D	0030425	cellular_component	dendrite
D	0030507	molecular_function	spectrin binding
D	0042622	cellular_component	photoreceptor outer segment membrane
D	0044297	cellular_component	cell body
D	0044877	molecular_function	protein-containing complex binding
D	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
D	0050909	biological_process	sensory perception of taste
D	0051020	molecular_function	GTPase binding
D	0060041	biological_process	retina development in camera-type eye
D	0071456	biological_process	cellular response to hypoxia
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005834	cellular_component	heterotrimeric G-protein complex
G	0005886	cellular_component	plasma membrane
G	0007165	biological_process	signal transduction
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
G	0016020	cellular_component	membrane
G	0031681	molecular_function	G-protein beta-subunit binding
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIySMTAIAVDRYMaI

Chain	Residue	Details
B	ALA171-ILE187

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site_id	PS00267
Number of Residues	5
Details	TACHYKININ Tachykinin family signature. FFGLM

Chain	Residue	Details
A	PHE7-MET11

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
D	LEU70-SER84
D	ILE157-ILE171
D	LEU285-ALA299
D	VAL327-GLY341

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site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
B	PRO676-ASN693
B	PRO1043-ASN1060

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by FAP => ECO:0000269|PubMed:21314817

Chain	Residue	Details
A	PRO2

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by MME => ECO:0000269|PubMed:6208535

Chain	Residue	Details
A	GLN6
A	PHE7

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by ACE => ECO:0000269|PubMed:6208535

Chain	Residue	Details
A	PHE8

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by ACE and MME => ECO:0000269|PubMed:6208535

Chain	Residue	Details
A	GLY9

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Methionine amide => ECO:0000269|PubMed:3770210

Chain	Residue	Details
A	MET11

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