Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8J6N

Crystal structure of Cystathionine gamma-lyase in complex with compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004123	molecular_function	cystathionine gamma-lyase activity
A	0016829	molecular_function	lyase activity
A	0016846	molecular_function	carbon-sulfur lyase activity
A	0019344	biological_process	cysteine biosynthetic process
A	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
A	0080146	molecular_function	L-cysteine desulfhydrase activity
B	0004123	molecular_function	cystathionine gamma-lyase activity
B	0016829	molecular_function	lyase activity
B	0016846	molecular_function	carbon-sulfur lyase activity
B	0019344	biological_process	cysteine biosynthetic process
B	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
B	0080146	molecular_function	L-cysteine desulfhydrase activity
C	0004123	molecular_function	cystathionine gamma-lyase activity
C	0016829	molecular_function	lyase activity
C	0016846	molecular_function	carbon-sulfur lyase activity
C	0019344	biological_process	cysteine biosynthetic process
C	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
C	0080146	molecular_function	L-cysteine desulfhydrase activity
D	0004123	molecular_function	cystathionine gamma-lyase activity
D	0016829	molecular_function	lyase activity
D	0016846	molecular_function	carbon-sulfur lyase activity
D	0019344	biological_process	cysteine biosynthetic process
D	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
D	0080146	molecular_function	L-cysteine desulfhydrase activity
E	0004123	molecular_function	cystathionine gamma-lyase activity
E	0016829	molecular_function	lyase activity
E	0016846	molecular_function	carbon-sulfur lyase activity
E	0019344	biological_process	cysteine biosynthetic process
E	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
E	0080146	molecular_function	L-cysteine desulfhydrase activity
F	0004123	molecular_function	cystathionine gamma-lyase activity
F	0016829	molecular_function	lyase activity
F	0016846	molecular_function	carbon-sulfur lyase activity
F	0019344	biological_process	cysteine biosynthetic process
F	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
F	0080146	molecular_function	L-cysteine desulfhydrase activity
G	0004123	molecular_function	cystathionine gamma-lyase activity
G	0016829	molecular_function	lyase activity
G	0016846	molecular_function	carbon-sulfur lyase activity
G	0019344	biological_process	cysteine biosynthetic process
G	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
G	0080146	molecular_function	L-cysteine desulfhydrase activity
H	0004123	molecular_function	cystathionine gamma-lyase activity
H	0016829	molecular_function	lyase activity
H	0016846	molecular_function	carbon-sulfur lyase activity
H	0019344	biological_process	cysteine biosynthetic process
H	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
H	0080146	molecular_function	L-cysteine desulfhydrase activity
I	0004123	molecular_function	cystathionine gamma-lyase activity
I	0016829	molecular_function	lyase activity
I	0016846	molecular_function	carbon-sulfur lyase activity
I	0019344	biological_process	cysteine biosynthetic process
I	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
I	0080146	molecular_function	L-cysteine desulfhydrase activity
J	0004123	molecular_function	cystathionine gamma-lyase activity
J	0016829	molecular_function	lyase activity
J	0016846	molecular_function	carbon-sulfur lyase activity
J	0019344	biological_process	cysteine biosynthetic process
J	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
J	0080146	molecular_function	L-cysteine desulfhydrase activity
K	0004123	molecular_function	cystathionine gamma-lyase activity
K	0016829	molecular_function	lyase activity
K	0016846	molecular_function	carbon-sulfur lyase activity
K	0019344	biological_process	cysteine biosynthetic process
K	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
K	0080146	molecular_function	L-cysteine desulfhydrase activity
L	0004123	molecular_function	cystathionine gamma-lyase activity
L	0016829	molecular_function	lyase activity
L	0016846	molecular_function	carbon-sulfur lyase activity
L	0019344	biological_process	cysteine biosynthetic process
L	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
L	0080146	molecular_function	L-cysteine desulfhydrase activity

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIcmcSATKYMnGHS

Chain	Residue	Details
A	ASP204-SER218

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG62
C	TYR114
C	ARG119
C	GLU339
D	ARG62
D	TYR114
D	ARG119
D	GLU339
E	ARG62
E	TYR114
E	ARG119
A	TYR114
E	GLU339
H	ARG62
H	TYR114
H	ARG119
H	GLU339
J	ARG62
J	TYR114
J	ARG119
J	GLU339
K	ARG62
A	ARG119
K	TYR114
K	ARG119
K	GLU339
F	ARG62
F	TYR114
F	ARG119
F	GLU339
G	ARG62
G	TYR114
G	ARG119
A	GLU339
G	GLU339
I	ARG62
I	TYR114
I	ARG119
I	GLU339
L	ARG62
L	TYR114
L	ARG119
L	GLU339
B	ARG62
B	TYR114
B	ARG119
B	GLU339
C	ARG62

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:22673903

Chain	Residue	Details
A	SER51
G	SER51
I	SER51
L	SER51
B	SER51
C	SER51
D	SER51
E	SER51
H	SER51
J	SER51
K	SER51
F	SER51

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250\|UniProtKB:P32929

Chain	Residue	Details
A	LYS212
G	LYS212
I	LYS212
L	LYS212
B	LYS212
C	LYS212
D	LYS212
E	LYS212
H	LYS212
J	LYS212
K	LYS212
F	LYS212

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)