8IZY
Human KCNQ2-CaM in complex with HN37
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA92-PHE112 | |
| B | ALA92-PHE112 | |
| C | ALA92-PHE112 | |
| D | ALA92-PHE112 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 128 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | SER113-SER122 | |
| A | GLN188-SER195 | |
| A | ALA253-TYR264 | |
| A | GLN286-ARG291 | |
| B | SER113-SER122 | |
| B | GLN188-SER195 | |
| B | ALA253-TYR264 | |
| B | GLN286-ARG291 | |
| C | SER113-SER122 | |
| C | GLN188-SER195 | |
| C | ALA253-TYR264 | |
| C | GLN286-ARG291 | |
| D | SER113-SER122 | |
| D | GLN188-SER195 | |
| D | ALA253-TYR264 | |
| D | GLN286-ARG291 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU123-VAL143 | |
| B | GLU123-VAL143 | |
| C | GLU123-VAL143 | |
| D | GLU123-VAL143 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 136 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG144-LYS166 | |
| A | LYS219-GLU231 | |
| B | ARG144-LYS166 | |
| B | LYS219-GLU231 | |
| C | ARG144-LYS166 | |
| C | LYS219-GLU231 | |
| D | ARG144-LYS166 | |
| D | LYS219-GLU231 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO167-SER187 | |
| B | PRO167-SER187 | |
| C | PRO167-SER187 | |
| D | PRO167-SER187 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 88 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA196-TRP218 | |
| B | ALA196-TRP218 | |
| C | ALA196-TRP218 | |
| D | ALA196-TRP218 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU232-LEU252 | |
| B | LEU232-LEU252 | |
| C | LEU232-LEU252 | |
| D | LEU232-LEU252 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA265-PRO285 | |
| B | ALA265-PRO285 | |
| C | ALA265-PRO285 | |
| D | ALA265-PRO285 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU292-LEU312 | |
| B | LEU292-LEU312 | |
| C | LEU292-LEU312 | |
| D | LEU292-LEU312 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:16319223 |
| Chain | Residue | Details |
| A | THR217 | |
| B | THR217 | |
| C | THR217 | |
| D | THR217 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z351 |
| Chain | Residue | Details |
| A | SER466 | |
| A | SER468 | |
| A | SER472 | |
| A | SER476 | |
| A | SER478 | |
| B | SER466 | |
| B | SER468 | |
| B | SER472 | |
| B | SER476 | |
| B | SER478 | |
| C | SER466 | |
| C | SER468 | |
| C | SER472 | |
| C | SER476 | |
| C | SER478 | |
| D | SER466 | |
| D | SER468 | |
| D | SER472 | |
| D | SER476 | |
| D | SER478 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88943 |
| Chain | Residue | Details |
| A | SER507 | |
| A | SER672 | |
| B | SER507 | |
| B | SER672 | |
| C | SER507 | |
| C | SER672 | |
| D | SER507 | |
| D | SER672 |
