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8IG0

Crystal structure of menin in complex with DS-1594b

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000165biological_processMAPK cascade
A0000400molecular_functionfour-way junction DNA binding
A0000403molecular_functionY-form DNA binding
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0000976molecular_functiontranscription cis-regulatory region binding
A0001933biological_processnegative regulation of protein phosphorylation
A0002076biological_processosteoblast development
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003690molecular_functiondouble-stranded DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006325biological_processchromatin organization
A0006357biological_processregulation of transcription by RNA polymerase II
A0006974biological_processDNA damage response
A0008285biological_processnegative regulation of cell population proliferation
A0009411biological_processresponse to UV
A0010332biological_processresponse to gamma radiation
A0016363cellular_componentnuclear matrix
A0017053cellular_componenttranscription repressor complex
A0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
A0030674molecular_functionprotein-macromolecule adaptor activity
A0032154cellular_componentcleavage furrow
A0032991cellular_componentprotein-containing complex
A0035097cellular_componenthistone methyltransferase complex
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0044665cellular_componentMLL1/2 complex
A0045064biological_processT-helper 2 cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
A0045786biological_processnegative regulation of cell cycle
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046329biological_processnegative regulation of JNK cascade
A0051219molecular_functionphosphoprotein binding
A0051974biological_processnegative regulation of telomerase activity
A0070412molecular_functionR-SMAD binding
A0071339cellular_componentMLL1 complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000165biological_processMAPK cascade
B0000400molecular_functionfour-way junction DNA binding
B0000403molecular_functionY-form DNA binding
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0000976molecular_functiontranscription cis-regulatory region binding
B0001933biological_processnegative regulation of protein phosphorylation
B0002076biological_processosteoblast development
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003690molecular_functiondouble-stranded DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006325biological_processchromatin organization
B0006357biological_processregulation of transcription by RNA polymerase II
B0006974biological_processDNA damage response
B0008285biological_processnegative regulation of cell population proliferation
B0009411biological_processresponse to UV
B0010332biological_processresponse to gamma radiation
B0016363cellular_componentnuclear matrix
B0017053cellular_componenttranscription repressor complex
B0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
B0030674molecular_functionprotein-macromolecule adaptor activity
B0032154cellular_componentcleavage furrow
B0032991cellular_componentprotein-containing complex
B0035097cellular_componenthistone methyltransferase complex
B0043433biological_processnegative regulation of DNA-binding transcription factor activity
B0044665cellular_componentMLL1/2 complex
B0045064biological_processT-helper 2 cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
B0045786biological_processnegative regulation of cell cycle
B0045815biological_processtranscription initiation-coupled chromatin remodeling
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046329biological_processnegative regulation of JNK cascade
B0051219molecular_functionphosphoprotein binding
B0051974biological_processnegative regulation of telomerase activity
B0070412molecular_functionR-SMAD binding
B0071339cellular_componentMLL1 complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000165biological_processMAPK cascade
C0000400molecular_functionfour-way junction DNA binding
C0000403molecular_functionY-form DNA binding
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0000976molecular_functiontranscription cis-regulatory region binding
C0001933biological_processnegative regulation of protein phosphorylation
C0002076biological_processosteoblast development
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003690molecular_functiondouble-stranded DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005788cellular_componentendoplasmic reticulum lumen
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006325biological_processchromatin organization
C0006357biological_processregulation of transcription by RNA polymerase II
C0006974biological_processDNA damage response
C0008285biological_processnegative regulation of cell population proliferation
C0009411biological_processresponse to UV
C0010332biological_processresponse to gamma radiation
C0016363cellular_componentnuclear matrix
C0017053cellular_componenttranscription repressor complex
C0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
C0030674molecular_functionprotein-macromolecule adaptor activity
C0032154cellular_componentcleavage furrow
C0032991cellular_componentprotein-containing complex
C0035097cellular_componenthistone methyltransferase complex
C0043433biological_processnegative regulation of DNA-binding transcription factor activity
C0044665cellular_componentMLL1/2 complex
C0045064biological_processT-helper 2 cell differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
C0045786biological_processnegative regulation of cell cycle
C0045815biological_processtranscription initiation-coupled chromatin remodeling
C0045892biological_processnegative regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046329biological_processnegative regulation of JNK cascade
C0051219molecular_functionphosphoprotein binding
C0051974biological_processnegative regulation of telomerase activity
C0070412molecular_functionR-SMAD binding
C0071339cellular_componentMLL1 complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000165biological_processMAPK cascade
D0000400molecular_functionfour-way junction DNA binding
D0000403molecular_functionY-form DNA binding
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0000976molecular_functiontranscription cis-regulatory region binding
D0001933biological_processnegative regulation of protein phosphorylation
D0002076biological_processosteoblast development
D0003677molecular_functionDNA binding
D0003682molecular_functionchromatin binding
D0003690molecular_functiondouble-stranded DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005788cellular_componentendoplasmic reticulum lumen
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006325biological_processchromatin organization
D0006357biological_processregulation of transcription by RNA polymerase II
D0006974biological_processDNA damage response
D0008285biological_processnegative regulation of cell population proliferation
D0009411biological_processresponse to UV
D0010332biological_processresponse to gamma radiation
D0016363cellular_componentnuclear matrix
D0017053cellular_componenttranscription repressor complex
D0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
D0030674molecular_functionprotein-macromolecule adaptor activity
D0032154cellular_componentcleavage furrow
D0032991cellular_componentprotein-containing complex
D0035097cellular_componenthistone methyltransferase complex
D0043433biological_processnegative regulation of DNA-binding transcription factor activity
D0044665cellular_componentMLL1/2 complex
D0045064biological_processT-helper 2 cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
D0045786biological_processnegative regulation of cell cycle
D0045815biological_processtranscription initiation-coupled chromatin remodeling
D0045892biological_processnegative regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046329biological_processnegative regulation of JNK cascade
D0051219molecular_functionphosphoprotein binding
D0051974biological_processnegative regulation of telomerase activity
D0070412molecular_functionR-SMAD binding
D0071339cellular_componentMLL1 complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
AGLU547
BGLU547
CGLU547
DGLU547

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU603
BLEU603
CLEU603
DLEU603

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails

219869

PDB entries from 2024-05-15

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