8I9D
S-ECD (Omicron XBB.1) in complex with PD of ACE2
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| F | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
| Chain | Residue | Details |
| F | GLU375 | |
| D | GLU375 | |
| E | GLU375 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| F | HIS505 | |
| D | HIS505 | |
| E | HIS505 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
| Chain | Residue | Details |
| F | ARG169 | |
| F | TRP477 | |
| F | LYS481 | |
| D | ARG169 | |
| D | TRP477 | |
| D | LYS481 | |
| E | ARG169 | |
| E | TRP477 | |
| E | LYS481 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| F | ARG273 | |
| F | HIS345 | |
| F | TYR515 | |
| D | ARG273 | |
| D | HIS345 | |
| D | TYR515 | |
| E | ARG273 | |
| E | HIS345 | |
| E | TYR515 | |
| B | ALA1078 | |
| C | TRP64 | |
| C | ASN125 | |
| C | SER721 | |
| C | ILE805 | |
| C | ALA1078 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| F | HIS374 | |
| F | HIS378 | |
| F | GLU402 | |
| D | HIS374 | |
| D | HIS378 | |
| D | GLU402 | |
| E | HIS374 | |
| E | HIS378 | |
| E | GLU402 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| F | ASN53 | |
| F | ASN322 | |
| D | ASN53 | |
| D | ASN322 | |
| E | ASN53 | |
| E | ASN322 | |
| A | TRP1102 | |
| B | GLU169 | |
| B | THR286 | |
| B | LEU335 | |
| B | PHE347 | |
| B | VAL620 | |
| B | GLU661 | |
| B | TRP1102 | |
| C | GLU169 | |
| C | THR286 | |
| C | LEU335 | |
| C | PHE347 | |
| C | VAL620 | |
| C | GLU661 | |
| C | TRP1102 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| F | ASN90 | |
| D | ASN90 | |
| E | ASN90 | |
| B | ALA713 | |
| C | PHE238 | |
| C | ALA713 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| F | ASN103 | |
| F | ASN432 | |
| D | ASN103 | |
| D | ASN432 | |
| E | ASN103 | |
| E | ASN432 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| F | ASN546 | |
| D | ASN546 | |
| E | ASN546 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | GLN607 | |
| B | GLN607 | |
| C | GLN607 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| A | SER680 | |
| A | GLY682 | |
| B | SER680 | |
| B | GLY682 | |
| C | SER680 | |
| C | GLY682 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | TYR1138 | |
| B | TYR1138 | |
| C | TYR1138 |
