8I9B
S-ECD (Omicron BA.2.75) in complex with PD of ACE2
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| F | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402 |
| Chain | Residue | Details |
| F | GLU375 | |
| D | GLU375 | |
| E | GLU375 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| F | HIS505 | |
| D | HIS505 | |
| E | HIS505 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774 |
| Chain | Residue | Details |
| F | ARG169 | |
| F | TRP477 | |
| F | LYS481 | |
| D | ARG169 | |
| D | TRP477 | |
| D | LYS481 | |
| E | ARG169 | |
| E | TRP477 | |
| E | LYS481 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| F | ARG273 | |
| F | HIS345 | |
| F | TYR515 | |
| D | ARG273 | |
| D | HIS345 | |
| D | TYR515 | |
| E | ARG273 | |
| E | HIS345 | |
| E | TYR515 | |
| B | THR1076 | |
| C | THR63 | |
| C | THR124 | |
| C | THR719 | |
| C | SER803 | |
| C | THR1076 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| F | HIS374 | |
| F | HIS378 | |
| F | GLU402 | |
| D | HIS374 | |
| D | HIS378 | |
| D | GLU402 | |
| E | HIS374 | |
| E | HIS378 | |
| E | GLU402 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895 |
| Chain | Residue | Details |
| F | ASN53 | |
| F | ASN322 | |
| D | ASN53 | |
| D | ASN322 | |
| E | ASN53 | |
| E | ASN322 | |
| A | THR1100 | |
| B | THR167 | |
| B | THR284 | |
| B | THR333 | |
| B | THR345 | |
| B | THR618 | |
| B | SER659 | |
| B | THR1100 | |
| C | THR167 | |
| C | THR284 | |
| C | THR333 | |
| C | THR345 | |
| C | THR618 | |
| C | SER659 | |
| C | THR1100 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| F | ASN90 | |
| D | ASN90 | |
| E | ASN90 | |
| B | SER711 | |
| C | THR236 | |
| C | SER711 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895 |
| Chain | Residue | Details |
| F | ASN103 | |
| F | ASN432 | |
| D | ASN103 | |
| D | ASN432 | |
| E | ASN103 | |
| E | ASN432 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337 |
| Chain | Residue | Details |
| F | ASN546 | |
| D | ASN546 | |
| E | ASN546 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | SER605 | |
| B | SER605 | |
| C | SER605 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| A | THR678 | |
| A | SER680 | |
| B | THR678 | |
| B | SER680 | |
| C | THR678 | |
| C | SER680 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | THR1136 | |
| B | THR1136 | |
| C | THR1136 |
