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8HTA

Solution Structure of the C65A/C167A Mutant of Human Lipocalin-type Prostaglandin D Synthase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0004667molecular_functionprostaglandin-D synthase activity
A0005501molecular_functionretinoid binding
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005791cellular_componentrough endoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0010467biological_processgene expression
A0016020cellular_componentmembrane
A0016853molecular_functionisomerase activity
A0019371biological_processcyclooxygenase pathway
A0031965cellular_componentnuclear membrane
A0036094molecular_functionsmall molecule binding
A0043303biological_processmast cell degranulation
A0045187biological_processregulation of circadian sleep/wake cycle, sleep
A0048471cellular_componentperinuclear region of cytoplasm
A0051384biological_processresponse to glucocorticoid
A0070062cellular_componentextracellular exosome
A2000255biological_processnegative regulation of male germ cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFQqdKFLGRWFSA
ChainResidueDetails
AASN33-ALA46

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:20667974
ChainResidueDetails
AALA65

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:23234360
ChainResidueDetails
ASER29

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:8336134
ChainResidueDetails
AASN51

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:8336134
ChainResidueDetails
AASN78

220113

PDB entries from 2024-05-22

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