8GT5
Crystal structure of human cardiac alpha actin Q137A mutant (ADP-Pi state) in complex with fragmin F1 domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000146 | molecular_function | microfilament motor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005884 | cellular_component | actin filament |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007015 | biological_process | actin filament organization |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017022 | molecular_function | myosin binding |
| A | 0030017 | cellular_component | sarcomere |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030048 | biological_process | actin filament-based movement |
| A | 0030175 | cellular_component | filopodium |
| A | 0030240 | biological_process | skeletal muscle thin filament assembly |
| A | 0031032 | biological_process | actomyosin structure organization |
| A | 0031674 | cellular_component | I band |
| A | 0033275 | biological_process | actin-myosin filament sliding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0044297 | cellular_component | cell body |
| A | 0045202 | cellular_component | synapse |
| A | 0055003 | biological_process | cardiac myofibril assembly |
| A | 0055008 | biological_process | cardiac muscle tissue morphogenesis |
| A | 0060047 | biological_process | heart contraction |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070252 | biological_process | actin-mediated cell contraction |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0090131 | biological_process | mesenchyme migration |
| A | 0098978 | cellular_component | glutamatergic synapse |
| B | 0051015 | molecular_function | actin filament binding |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WISKqEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P68033 |
| Chain | Residue | Details |
| A | MET44 | |
| A | MET47 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Tele-methylhistidine => ECO:0000269|PubMed:30626964 |
| Chain | Residue | Details |
| A | HIC73 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:23673617 |
| Chain | Residue | Details |
| A | LYS84 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-272); by Vibrio toxins RtxA and VgrG1 => ECO:0000250|UniProtKB:P60709 |
| Chain | Residue | Details |
| A | LYS50 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-52); by Vibrio toxins RtxA and VgrG1 => ECO:0000250|UniProtKB:P60709 |
| Chain | Residue | Details |
| A | GLU270 |
