8GCY

Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001784	molecular_function	phosphotyrosine residue binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005509	molecular_function	calcium ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

Chain	Residue	Details
A	CYS388-LEU397

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
A	CYS373-ARG412

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P22681

Chain	Residue	Details
A	ASP221
A	THR223
A	ASN225
A	TYR227
A	GLU232

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG286

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC/PRKCQ => ECO:0000269|PubMed:19549985

Chain	Residue	Details
A	SER282

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:20525694

Chain	Residue	Details
A	TYR363

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