8FY5
Human TMEM175-LAMP1 full-length complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015252 | molecular_function | proton channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022841 | molecular_function | potassium ion leak channel activity |
| A | 0035751 | biological_process | regulation of lysosomal lumen pH |
| A | 0035752 | biological_process | lysosomal lumen pH elevation |
| A | 0050544 | molecular_function | arachidonic acid binding |
| A | 0070050 | biological_process | neuron cellular homeostasis |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0090385 | biological_process | phagosome-lysosome fusion |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015252 | molecular_function | proton channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0022841 | molecular_function | potassium ion leak channel activity |
| B | 0035751 | biological_process | regulation of lysosomal lumen pH |
| B | 0035752 | biological_process | lysosomal lumen pH elevation |
| B | 0050544 | molecular_function | arachidonic acid binding |
| B | 0070050 | biological_process | neuron cellular homeostasis |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0090385 | biological_process | phagosome-lysosome fusion |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0016020 | cellular_component | membrane |
| D | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00310 |
| Number of Residues | 15 |
| Details | LAMP_1 Lysosome-associated membrane glycoproteins duplicated domain signature. ACIMAnFsaaFsvnY |
| Chain | Residue | Details |
| C | ALA40-TYR54 | |
| C | THR230-TYR244 |
| site_id | PS00311 |
| Number of Residues | 41 |
| Details | LAMP_2 LAMP glycoproteins transmembrane and cytoplasmic domain signature. CllDensmLIPIaVGgaLaGLVlIVLIAYlVgrKRshAGYQ |
| Chain | Residue | Details |
| C | CYS375-GLN415 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 706 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| C | ALA29-MET382 | |
| D | ALA29-MET382 | |
| B | MET1-SER33 | |
| B | LEU470-CYS504 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000305|PubMed:37390818, ECO:0007744|PDB:8FY5, ECO:0007744|PDB:8FYF |
| Chain | Residue | Details |
| C | LEU383-SER410 | |
| D | LEU383-SER410 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255|PROSITE-ProRule:PRU00740 |
| Chain | Residue | Details |
| A | PHE206-SER210 | |
| A | ASP283-ARG309 | |
| A | GLN361-ARG375 | |
| A | SER441-ARG442 | |
| B | HIS57-ARG77 | |
| B | LEU129-LEU138 | |
| B | PHE206-SER210 | |
| B | ASP283-ARG309 | |
| B | GLN361-ARG375 | |
| B | SER441-ARG442 | |
| C | HIS411-ILE417 | |
| D | HIS411-ILE417 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8323299 |
| Chain | Residue | Details |
| C | ASN37 | |
| C | ASN45 | |
| C | ASN107 | |
| C | ASN241 | |
| C | ASN322 | |
| D | ASN37 | |
| D | ASN45 | |
| D | ASN107 | |
| D | ASN241 | |
| D | ASN322 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (polylactosaminoglycan) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN62 | |
| D | ASN62 | |
| A | ARG231-SER257 | |
| A | HIS333-THR338 | |
| A | ALA397-HIS416 | |
| B | VAL101-ASP106 | |
| B | ALA161-HIS184 | |
| B | ARG231-SER257 | |
| B | HIS333-THR338 | |
| B | ALA397-HIS416 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:2243102 |
| Chain | Residue | Details |
| C | ASN76 | |
| D | ASN76 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN84 | |
| C | ASN293 | |
| D | ASN84 | |
| D | ASN293 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN103 | |
| D | ASN103 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) (polylactosaminoglycan) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN121 | |
| C | ASN130 | |
| D | ASN121 | |
| D | ASN130 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2243102, ECO:0000269|PubMed:8323299 |
| Chain | Residue | Details |
| C | ASN165 | |
| C | ASN181 | |
| C | ASN261 | |
| D | ASN165 | |
| D | ASN181 | |
| D | ASN261 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:8323299 |
| Chain | Residue | Details |
| C | SER197 | |
| D | SER197 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:8323299 |
| Chain | Residue | Details |
| C | THR199 | |
| C | THR200 | |
| D | THR199 | |
| D | THR200 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:8323299 |
| Chain | Residue | Details |
| C | SER207 | |
| C | SER209 | |
| C | SER211 | |
| D | SER207 | |
| D | SER209 | |
| D | SER211 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) (polylactosaminoglycan) asparagine => ECO:0000269|PubMed:8323299 |
| Chain | Residue | Details |
| C | ASN223 | |
| C | ASN228 | |
| D | ASN223 | |
| D | ASN228 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN249 | |
| D | ASN249 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 1-1 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | ILE46 | |
| B | ILE46 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 2-1 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| A | VAL50 | |
| B | VAL50 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 3-1 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| A | LEU53 | |
| B | LEU53 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 1-2 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | ILE271 | |
| B | ILE271 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 2-2 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| A | LEU275 | |
| B | LEU275 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic filter residue 3-2 => ECO:0000250|UniProtKB:K9UJK2 |
| Chain | Residue | Details |
| A | LEU278 | |
| B | LEU278 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | THR6 | |
| B | THR6 |
