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8FW5

Chimeric HsGATOR1-SpGtr-SpLam complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005096molecular_functionGTPase activator activity
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0010508biological_processpositive regulation of autophagy
A0016020cellular_componentmembrane
A0031267molecular_functionsmall GTPase binding
A0031463cellular_componentCul3-RING ubiquitin ligase complex
A0034198biological_processcellular response to amino acid starvation
A0035556biological_processintracellular signal transduction
A0044877molecular_functionprotein-containing complex binding
A0048471cellular_componentperinuclear region of cytoplasm
A1904262biological_processnegative regulation of TORC1 signaling
A1990130cellular_componentGATOR1 complex
B0005096molecular_functionGTPase activator activity
B0005515molecular_functionprotein binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005774cellular_componentvacuolar membrane
B0010508biological_processpositive regulation of autophagy
B0016020cellular_componentmembrane
B0033673biological_processnegative regulation of kinase activity
B0034198biological_processcellular response to amino acid starvation
B1904262biological_processnegative regulation of TORC1 signaling
B1990130cellular_componentGATOR1 complex
C0003281biological_processventricular septum development
C0005096molecular_functionGTPase activator activity
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0010508biological_processpositive regulation of autophagy
C0016020cellular_componentmembrane
C0032007biological_processnegative regulation of TOR signaling
C0034198biological_processcellular response to amino acid starvation
C0035909biological_processaorta morphogenesis
C0038202biological_processTORC1 signaling
C0048738biological_processcardiac muscle tissue development
C0060021biological_processroof of mouth development
C1904262biological_processnegative regulation of TORC1 signaling
C1990130cellular_componentGATOR1 complex
D0000329cellular_componentfungal-type vacuole membrane
D0003924molecular_functionGTPase activity
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005773cellular_componentvacuole
D0005774cellular_componentvacuolar membrane
D0005829cellular_componentcytosol
D0009267biological_processcellular response to starvation
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0110045biological_processnegative regulation of cell cycle switching, mitotic to meiotic cell cycle
D1904262biological_processnegative regulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
D1990131cellular_componentGtr1-Gtr2 GTPase complex
E0000329cellular_componentfungal-type vacuole membrane
E0003924molecular_functionGTPase activity
E0005525molecular_functionGTP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005773cellular_componentvacuole
E0005774cellular_componentvacuolar membrane
E0005829cellular_componentcytosol
E0009267biological_processcellular response to starvation
E0010507biological_processnegative regulation of autophagy
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0110045biological_processnegative regulation of cell cycle switching, mitotic to meiotic cell cycle
E1904263biological_processpositive regulation of TORC1 signaling
E1990131cellular_componentGtr1-Gtr2 GTPase complex
F0000329cellular_componentfungal-type vacuole membrane
F0003674molecular_functionmolecular_function
F0004364molecular_functionglutathione transferase activity
F0006749biological_processglutathione metabolic process
F0016740molecular_functiontransferase activity
F0071986cellular_componentRagulator complex
F1903432biological_processregulation of TORC1 signaling
G0000329cellular_componentfungal-type vacuole membrane
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0032008biological_processpositive regulation of TOR signaling
G0043495molecular_functionprotein-membrane adaptor activity
G0060090molecular_functionmolecular adaptor activity
G0071230biological_processcellular response to amino acid stimulus
G0071986cellular_componentRagulator complex
G1903432biological_processregulation of TORC1 signaling
G1904262biological_processnegative regulation of TORC1 signaling
H0000329cellular_componentfungal-type vacuole membrane
H0003674molecular_functionmolecular_function
H0071986cellular_componentRagulator complex
H1903432biological_processregulation of TORC1 signaling
I0000329cellular_componentfungal-type vacuole membrane
I0003674molecular_functionmolecular_function
I0071986cellular_componentRagulator complex
I1903432biological_processregulation of TORC1 signaling
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270
ChainResidueDetails
FTRP-183
FASN-170
FGLN-157
EASP121
DTHR31
DTHR37
DGLY60
DHIS122
DASP125
DILE159
FTYR-217

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
FTYR-113

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Asymmetric dimethylarginine => ECO:0000269|PubMed:38006878
ChainResidueDetails
BARG78

site_idSWS_FT_FI4
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36528027
ChainResidueDetails
BLYS158
BLYS357

221051

PDB entries from 2024-06-12

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