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8FE1

Alpha1/BetaB Heteromeric Glycine Receptor in 1 mM Glycine 20 uM Ivermectin State

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0016020cellular_componentmembrane
A0016594molecular_functionglycine binding
A0016934molecular_functionextracellularly glycine-gated chloride channel activity
A0022824molecular_functiontransmitter-gated monoatomic ion channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0045211cellular_componentpostsynaptic membrane
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0016020cellular_componentmembrane
B0016594molecular_functionglycine binding
B0016934molecular_functionextracellularly glycine-gated chloride channel activity
B0022824molecular_functiontransmitter-gated monoatomic ion channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0045211cellular_componentpostsynaptic membrane
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0016020cellular_componentmembrane
C0016594molecular_functionglycine binding
C0016934molecular_functionextracellularly glycine-gated chloride channel activity
C0022824molecular_functiontransmitter-gated monoatomic ion channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0045211cellular_componentpostsynaptic membrane
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0016020cellular_componentmembrane
D0016594molecular_functionglycine binding
D0016934molecular_functionextracellularly glycine-gated chloride channel activity
D0022824molecular_functiontransmitter-gated monoatomic ion channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0045211cellular_componentpostsynaptic membrane
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005254molecular_functionchloride channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0008104biological_processprotein localization
E0016020cellular_componentmembrane
E0016934molecular_functionextracellularly glycine-gated chloride channel activity
E0030594molecular_functionneurotransmitter receptor activity
E0034220biological_processmonoatomic ion transmembrane transport
E0043005cellular_componentneuron projection
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0060012biological_processsynaptic transmission, glycinergic
E0060079biological_processexcitatory postsynaptic potential
E1902476biological_processchloride transmembrane transport
E1902495cellular_componenttransmembrane transporter complex
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpLdLtlFPmDtqrC
ChainResidueDetails
ECYS182-CYS196
ACYS162-CYS176

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues964
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:26344198
ChainResidueDetails
AALA25-TYR246
AARG295-LYS305
ALYS434-GLN444
DALA25-TYR246
DARG295-LYS305
DLYS434-GLN444
CALA25-TYR246
CARG295-LYS305
CLYS434-GLN444
BALA25-TYR246
BARG295-LYS305
BLYS434-GLN444

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26344198
ChainResidueDetails
ATYR247-ILE268
DTYR247-ILE268
CTYR247-ILE268
BTYR247-ILE268

site_idSWS_FT_FI3
Number of Residues356
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26344198
ChainResidueDetails
AASN269-ALA273
AALA327-THR412
DASN269-ALA273
DALA327-THR412
CASN269-ALA273
CALA327-THR412
BASN269-ALA273
BALA327-THR412

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26344198
ChainResidueDetails
APRO274-SER294
DPRO274-SER294
CPRO274-SER294
BPRO274-SER294

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26344198
ChainResidueDetails
AALA306-ALA326
DALA306-ALA326
CALA306-ALA326
BALA306-ALA326

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26344198
ChainResidueDetails
AVAL413-TYR433
DVAL413-TYR433
CVAL413-TYR433
BVAL413-TYR433

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P23415
ChainResidueDetails
AGLU216
AASP218
AHIS239
DGLU216
DASP218
DHIS239
CGLU216
CASP218
CHIS239
BGLU216
BASP218
BHIS239

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:26344198
ChainResidueDetails
ATYR226
DTYR226
CTYR226
BTYR226

site_idSWS_FT_FI9
Number of Residues4
DetailsSITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26344198
ChainResidueDetails
ALEU285
DLEU285
CLEU285
BLEU285

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26344198
ChainResidueDetails
AASN62
DASN62
CASN62
BASN62

221051

PDB entries from 2024-06-12

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