8F0P
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 590 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | MET1-PRO140 | |
| A | ARG187-PRO200 | |
| A | PRO242-ASP260 | |
| A | VAL414-PRO519 | |
| A | ILE570-TRP583 | |
| A | TRP624-GLY639 | |
| A | LEU741-TYR857 | |
| A | MET908-LYS921 | |
| A | VAL965-HIS981 | |
| A | LEU1411-ASN1553 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ILE141-MET159 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 267 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | PRO160-THR165 | |
| A | ASP219-TYR224 | |
| A | MET281-THR360 | |
| A | ARG386-HIS392 | |
| A | ASP539-ARG549 | |
| A | GLN604-GLY605 | |
| A | GLY659-ASP686 | |
| A | ASP708-PRO719 | |
| A | GLU876-ASN888 | |
| A | CYS941-GLU945 | |
| A | GLN1002-VAL1047 | |
| A | ALA1070-ILE1086 | |
| A | GLY1317-THR1338 | |
| A | ILE1362-GLY1387 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | TYR166-ALA186 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | TRP201-VAL218 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ALA225-VAL241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | LEU261-PHE280 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | PHE361-LEU385 | |
| A | PHE687-TRP707 | |
| A | GLY1048-ASP1069 | |
| A | PHE1339-ALA1361 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ILE393-ALA413 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | PHE520-LEU538 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ILE550-LYS569 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ASN584-VAL603 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | LEU606-PHE623 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ALA640-ILE658 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | PHE720-LEU740 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | PHE858-LEU875 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ILE889-ILE907 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | TRP922-MET940 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ALA946-LYS964 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ILE982-VAL1001 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | TYR1087-VAL1108 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | LEU1299-PHE1316 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ILE1388-ILE1410 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A91 |
| Chain | Residue | Details |
| A | GLU378 | |
| A | TRP1063 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30049784, ECO:0007744|PDB:6A95 |
| Chain | Residue | Details |
| A | GLU701 | |
| A | GLU704 | |
| A | GLY1062 | |
| A | GLY1354 | |
| A | ASP1356 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 7 |
| Details | SITE: Interacts with the spider Mu-diguetoxin-Dc1a => ECO:0000269|PubMed:30049784 |
| Chain | Residue | Details |
| A | ASP539 | |
| A | ASP542 | |
| A | ARG549 | |
| A | ARG613 | |
| A | GLN1002 | |
| A | ARG1027 | |
| A | HIS1032 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ASN300 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28183995, ECO:0000269|PubMed:30049784, ECO:0007744|PDB:5X0M, ECO:0007744|PDB:6A90, ECO:0007744|PDB:6A91, ECO:0007744|PDB:6A95 |
| Chain | Residue | Details |
| A | ASN308 | |
| A | ASN312 | |
| A | ASN330 | |
| A | ASN1015 | |
| A | ASN1034 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN683 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; atypical => ECO:0000269|PubMed:28183995, ECO:0007744|PDB:5X0M |
| Chain | Residue | Details |
| A | ASN1028 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1172-VAL1189 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 22 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | GLU1190-GLU1200 | |
| A | LEU1250-THR1262 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL1201-LEU1219 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 11 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | LYS1220-VAL1231 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | GLY1232-PHE1249 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1263-VAL1279 |
