8EV8
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, closed state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0001750 | cellular_component | photoreceptor outer segment |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005222 | molecular_function | intracellularly cAMP-activated cation channel activity |
| D | 0005223 | molecular_function | intracellularly cGMP-activated cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0007165 | biological_process | signal transduction |
| D | 0007601 | biological_process | visual perception |
| D | 0016020 | cellular_component | membrane |
| D | 0017071 | cellular_component | intracellular cyclic nucleotide activated cation channel complex |
| D | 0030553 | molecular_function | cGMP binding |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0098655 | biological_process | monoatomic cation transmembrane transport |
| D | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGKeMYIIneG |
| Chain | Residue | Details |
| A | ILE509-GLY525 | |
| D | VAL551-GLY567 |
| site_id | PS00889 |
| Number of Residues | 24 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSIlnikgsksgnrRTAnIrS |
| Chain | Residue | Details |
| A | PHE547-SER570 | |
| D | PHE590-ALA610 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=H1 => ECO:0000255 |
| Chain | Residue | Details |
| D | LEU217-PRO237 | |
| B | LEU167-ILE187 | |
| C | LEU167-ILE187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| D | LEU238-ILE250 | |
| D | ARG324-TYR359 | |
| D | GLY439-THR504 | |
| B | CYS188-TYR199 | |
| B | ARG274-ARG302 | |
| B | GLY400-ARG481 | |
| C | CYS188-TYR199 | |
| C | ARG274-ARG302 | |
| C | GLY400-ARG481 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=H2 => ECO:0000255 |
| Chain | Residue | Details |
| D | HIS251-ILE271 | |
| B | LEU200-VAL220 | |
| C | LEU200-VAL220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 349 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| D | GLN272-LEU302 | |
| D | GLY381-LEU417 | |
| D | LYS526-GLN809 | |
| B | ARG221-ASP252 | |
| B | ILE324-TYR378 | |
| B | PHE503-GLN694 | |
| C | ARG221-ASP252 | |
| C | ILE324-TYR378 | |
| C | PHE503-GLN694 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=H3 => ECO:0000255 |
| Chain | Residue | Details |
| D | ASP303-PHE323 | |
| B | VAL253-VAL273 | |
| C | VAL253-VAL273 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=H4 => ECO:0000255 |
| Chain | Residue | Details |
| D | LEU360-ILE380 | |
| B | ILE303-ALA323 | |
| C | ILE303-ALA323 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=H5 => ECO:0000255 |
| Chain | Residue | Details |
| D | PHE418-ILE438 | |
| B | LEU379-VAL399 | |
| C | LEU379-VAL399 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=H6 => ECO:0000255 |
| Chain | Residue | Details |
| D | THR505-PHE525 | |
| B | ILE482-VAL502 | |
| C | ILE482-VAL502 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| D | MET532 | |
| D | GLU592 | |
| D | ARG604 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN468 | |
| A | ARG564 | |
| B | GLU549 | |
| B | ARG564 | |
| C | GLU549 | |
| C | ARG564 |
