Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8ERA

RMC-5552 in complex with mTORC1 and FKBP12

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0001932biological_processregulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0002296biological_processT-helper 1 cell lineage commitment
A0003007biological_processheart morphogenesis
A0003179biological_processheart valve morphogenesis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006112biological_processenergy reserve metabolic process
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0007040biological_processlysosome organization
A0007281biological_processgerm cell development
A0007584biological_processresponse to nutrient
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009791biological_processpost-embryonic development
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010592biological_processpositive regulation of lamellipodium assembly
A0010628biological_processpositive regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010831biological_processpositive regulation of myotube differentiation
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016605cellular_componentPML body
A0018105biological_processpeptidyl-serine phosphorylation
A0019228biological_processneuronal action potential
A0030030biological_processcell projection organization
A0030163biological_processprotein catabolic process
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030838biological_processpositive regulation of actin filament polymerization
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032516biological_processpositive regulation of phosphoprotein phosphatase activity
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034198biological_processcellular response to amino acid starvation
A0035264biological_processmulticellular organism growth
A0038202biological_processTORC1 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045792biological_processnegative regulation of cell size
A0045821biological_processpositive regulation of glycolytic process
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045948biological_processpositive regulation of translational initiation
A0046777biological_processprotein autophosphorylation
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0048511biological_processrhythmic process
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0048738biological_processcardiac muscle tissue development
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050882biological_processvoluntary musculoskeletal movement
A0051128biological_processregulation of cellular component organization
A0051219molecular_functionphosphoprotein binding
A0051247biological_processpositive regulation of protein metabolic process
A0051496biological_processpositive regulation of stress fiber assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0051647biological_processnucleus localization
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0055013biological_processcardiac muscle cell development
A0060048biological_processcardiac muscle contraction
A0061431biological_processcellular response to methionine
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0090559biological_processregulation of membrane permeability
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1904059biological_processregulation of locomotor rhythm
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000785biological_processregulation of autophagosome assembly
B0000413biological_processprotein peptidyl-prolyl isomerization
B0003007biological_processheart morphogenesis
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005527molecular_functionmacrolide binding
B0005528molecular_functionFK506 binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006457biological_processprotein folding
B0006458biological_process'de novo' protein folding
B0014802cellular_componentterminal cisterna
B0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016247molecular_functionchannel regulator activity
B0016529cellular_componentsarcoplasmic reticulum
B0022417biological_processprotein maturation by protein folding
B0030018cellular_componentZ disc
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0030547molecular_functionsignaling receptor inhibitor activity
B0032092biological_processpositive regulation of protein binding
B0032880biological_processregulation of protein localization
B0032926biological_processnegative regulation of activin receptor signaling pathway
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034713molecular_functiontype I transforming growth factor beta receptor binding
B0042026biological_processprotein refolding
B0042110biological_processT cell activation
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044325molecular_functiontransmembrane transporter binding
B0050776biological_processregulation of immune response
B0055010biological_processventricular cardiac muscle tissue morphogenesis
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060347biological_processheart trabecula formation
B0070411molecular_functionI-SMAD binding
B0070588biological_processcalcium ion transmembrane transport
B0070697molecular_functionactivin receptor binding
B0097435biological_processsupramolecular fiber organization
B0098562cellular_componentcytoplasmic side of membrane
B1902991biological_processregulation of amyloid precursor protein catabolic process
B1990000biological_processamyloid fibril formation
B1990425cellular_componentryanodine receptor complex
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006974biological_processDNA damage response
C0007010biological_processcytoskeleton organization
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0030307biological_processpositive regulation of cell growth
C0030838biological_processpositive regulation of actin filament polymerization
C0031669biological_processcellular response to nutrient levels
C0031929biological_processTOR signaling
C0031931cellular_componentTORC1 complex
C0031932cellular_componentTORC2 complex
C0032008biological_processpositive regulation of TOR signaling
C0032956biological_processregulation of actin cytoskeleton organization
C0038202biological_processTORC1 signaling
C0043066biological_processnegative regulation of apoptotic process
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045821biological_processpositive regulation of glycolytic process
C0046889biological_processpositive regulation of lipid biosynthetic process
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0071456biological_processcellular response to hypoxia
C0071470biological_processcellular response to osmotic stress
C1905857biological_processpositive regulation of pentose-phosphate shunt
Y0001558biological_processregulation of cell growth
Y0001938biological_processpositive regulation of endothelial cell proliferation
Y0005515molecular_functionprotein binding
Y0005654cellular_componentnucleoplasm
Y0005737cellular_componentcytoplasm
Y0005764cellular_componentlysosome
Y0005765cellular_componentlysosomal membrane
Y0005829cellular_componentcytosol
Y0006974biological_processDNA damage response
Y0008361biological_processregulation of cell size
Y0009267biological_processcellular response to starvation
Y0009410biological_processresponse to xenobiotic stimulus
Y0010494cellular_componentcytoplasmic stress granule
Y0010506biological_processregulation of autophagy
Y0010507biological_processnegative regulation of autophagy
Y0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
Y0016020cellular_componentmembrane
Y0019901molecular_functionprotein kinase binding
Y0030291molecular_functionprotein serine/threonine kinase inhibitor activity
Y0030295molecular_functionprotein kinase activator activity
Y0030307biological_processpositive regulation of cell growth
Y0030425cellular_componentdendrite
Y0030674molecular_functionprotein-macromolecule adaptor activity
Y0031267molecular_functionsmall GTPase binding
Y0031669biological_processcellular response to nutrient levels
Y0031929biological_processTOR signaling
Y0031931cellular_componentTORC1 complex
Y0032008biological_processpositive regulation of TOR signaling
Y0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Y0035176biological_processsocial behavior
Y0038202biological_processTORC1 signaling
Y0042325biological_processregulation of phosphorylation
Y0043025cellular_componentneuronal cell body
Y0044877molecular_functionprotein-containing complex binding
Y0045672biological_processpositive regulation of osteoclast differentiation
Y0045821biological_processpositive regulation of glycolytic process
Y0045945biological_processpositive regulation of transcription by RNA polymerase III
Y0046889biological_processpositive regulation of lipid biosynthetic process
Y0071230biological_processcellular response to amino acid stimulus
Y0071233biological_processcellular response to L-leucine
Y0071333biological_processcellular response to glucose stimulus
Y0071456biological_processcellular response to hypoxia
Y0071470biological_processcellular response to osmotic stress
Y0071889molecular_function14-3-3 protein binding
Y0140767molecular_functionenzyme-substrate adaptor activity
Y1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
Y1901331biological_processpositive regulation of odontoblast differentiation
Y1905857biological_processpositive regulation of pentose-phosphate shunt
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
CMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:31530866
ChainResidueDetails
YSER122
YSER836
YSER982
YSER44
ATYR2225
AGLY2238
ATRP2239
AVAL2240
ATHR2245
AMET2345
AILE2356

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER696
AASN2343
AASP2357

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866
ChainResidueDetails
YTHR706

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER719

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121
ChainResidueDetails
YSER721

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine; by AMPK and RPS6KA1 => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:37541260, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER722

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
YSER738

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131
ChainResidueDetails
YSER791

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260
ChainResidueDetails
YSER792

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431
ChainResidueDetails
YSER855

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER859

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER863

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
YTHR865

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
YSER877

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715
ChainResidueDetails
YLYS1097

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260
ChainResidueDetails
YTHR700

site_idSWS_FT_FI17
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303
ChainResidueDetails
YLYS932
YLYS948

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
BTYR27electrostatic destabiliser, steric role
BPHE37electrostatic destabiliser, polar/non-polar interaction, steric role
BASP38electrostatic stabiliser, steric role
BILE57electrostatic stabiliser, steric role
BTYR83electrostatic stabiliser, steric role
BPHE100electrostatic destabiliser, polar/non-polar interaction, steric role

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon