Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ENC

Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005884	cellular_component	actin filament
B	0007015	biological_process	actin filament organization
B	0010628	biological_process	positive regulation of gene expression
B	0017022	molecular_function	myosin binding
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0033275	biological_process	actin-myosin filament sliding
B	0044297	cellular_component	cell body
B	0060047	biological_process	heart contraction
B	0090131	biological_process	mesenchyme migration
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005884	cellular_component	actin filament
C	0007015	biological_process	actin filament organization
C	0010628	biological_process	positive regulation of gene expression
C	0017022	molecular_function	myosin binding
C	0030017	cellular_component	sarcomere
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0033275	biological_process	actin-myosin filament sliding
C	0044297	cellular_component	cell body
C	0060047	biological_process	heart contraction
C	0090131	biological_process	mesenchyme migration
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005884	cellular_component	actin filament
D	0007015	biological_process	actin filament organization
D	0010628	biological_process	positive regulation of gene expression
D	0017022	molecular_function	myosin binding
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0033275	biological_process	actin-myosin filament sliding
D	0044297	cellular_component	cell body
D	0060047	biological_process	heart contraction
D	0090131	biological_process	mesenchyme migration
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005884	cellular_component	actin filament
E	0007015	biological_process	actin filament organization
E	0010628	biological_process	positive regulation of gene expression
E	0017022	molecular_function	myosin binding
E	0030017	cellular_component	sarcomere
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0033275	biological_process	actin-myosin filament sliding
E	0044297	cellular_component	cell body
E	0060047	biological_process	heart contraction
E	0090131	biological_process	mesenchyme migration
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005884	cellular_component	actin filament
F	0007015	biological_process	actin filament organization
F	0010628	biological_process	positive regulation of gene expression
F	0017022	molecular_function	myosin binding
F	0030017	cellular_component	sarcomere
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0033275	biological_process	actin-myosin filament sliding
F	0044297	cellular_component	cell body
F	0060047	biological_process	heart contraction
F	0090131	biological_process	mesenchyme migration
M	0000146	molecular_function	microfilament motor activity
M	0001725	cellular_component	stress fiber
M	0002026	biological_process	regulation of the force of heart contraction
M	0002027	biological_process	regulation of heart rate
M	0003009	biological_process	skeletal muscle contraction
M	0003774	molecular_function	cytoskeletal motor activity
M	0003779	molecular_function	actin binding
M	0005515	molecular_function	protein binding
M	0005516	molecular_function	calmodulin binding
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005859	cellular_component	muscle myosin complex
M	0006936	biological_process	muscle contraction
M	0006941	biological_process	striated muscle contraction
M	0007512	biological_process	adult heart development
M	0014728	biological_process	regulation of the force of skeletal muscle contraction
M	0014883	biological_process	transition between fast and slow fiber
M	0014898	biological_process	cardiac muscle hypertrophy in response to stress
M	0016459	cellular_component	myosin complex
M	0016460	cellular_component	myosin II complex
M	0030016	cellular_component	myofibril
M	0030017	cellular_component	sarcomere
M	0030018	cellular_component	Z disc
M	0030049	biological_process	muscle filament sliding
M	0031449	biological_process	regulation of slow-twitch skeletal muscle fiber contraction
M	0032982	cellular_component	myosin filament
M	0045214	biological_process	sarcomere organization
M	0046034	biological_process	ATP metabolic process
M	0051015	molecular_function	actin filament binding
M	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
M	0060048	biological_process	cardiac muscle contraction
O	0001725	cellular_component	stress fiber
O	0003065	biological_process	positive regulation of heart rate by epinephrine
O	0003779	molecular_function	actin binding
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005862	cellular_component	muscle thin filament tropomyosin
O	0005884	cellular_component	actin filament
O	0006937	biological_process	regulation of muscle contraction
O	0007010	biological_process	cytoskeleton organization
O	0007015	biological_process	actin filament organization
O	0008016	biological_process	regulation of heart contraction
O	0008092	molecular_function	cytoskeletal protein binding
O	0008307	molecular_function	structural constituent of muscle
O	0008360	biological_process	regulation of cell shape
O	0015629	cellular_component	actin cytoskeleton
O	0030017	cellular_component	sarcomere
O	0030049	biological_process	muscle filament sliding
O	0030336	biological_process	negative regulation of cell migration
O	0031529	biological_process	ruffle organization
O	0032059	cellular_component	bleb
O	0032587	cellular_component	ruffle membrane
O	0032781	biological_process	positive regulation of ATP-dependent activity
O	0034614	biological_process	cellular response to reactive oxygen species
O	0042060	biological_process	wound healing
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0045214	biological_process	sarcomere organization
O	0045785	biological_process	positive regulation of cell adhesion
O	0046982	molecular_function	protein heterodimerization activity
O	0051015	molecular_function	actin filament binding
O	0051496	biological_process	positive regulation of stress fiber assembly
O	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
O	0060048	biological_process	cardiac muscle contraction
O	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
O	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
P	0001725	cellular_component	stress fiber
P	0003065	biological_process	positive regulation of heart rate by epinephrine
P	0003779	molecular_function	actin binding
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005862	cellular_component	muscle thin filament tropomyosin
P	0005884	cellular_component	actin filament
P	0006937	biological_process	regulation of muscle contraction
P	0007010	biological_process	cytoskeleton organization
P	0007015	biological_process	actin filament organization
P	0008016	biological_process	regulation of heart contraction
P	0008092	molecular_function	cytoskeletal protein binding
P	0008307	molecular_function	structural constituent of muscle
P	0008360	biological_process	regulation of cell shape
P	0015629	cellular_component	actin cytoskeleton
P	0030017	cellular_component	sarcomere
P	0030049	biological_process	muscle filament sliding
P	0030336	biological_process	negative regulation of cell migration
P	0031529	biological_process	ruffle organization
P	0032059	cellular_component	bleb
P	0032587	cellular_component	ruffle membrane
P	0032781	biological_process	positive regulation of ATP-dependent activity
P	0034614	biological_process	cellular response to reactive oxygen species
P	0042060	biological_process	wound healing
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0045214	biological_process	sarcomere organization
P	0045785	biological_process	positive regulation of cell adhesion
P	0046982	molecular_function	protein heterodimerization activity
P	0051015	molecular_function	actin filament binding
P	0051496	biological_process	positive regulation of stress fiber assembly
P	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
P	0060048	biological_process	cardiac muscle contraction
P	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
P	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
B	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
B	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
B	LEU104-ARG116

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
O	LEU232-GLU240

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269\|PubMed:3548719

Chain	Residue	Details
O	MET1
P	MET1

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P04692

Chain	Residue	Details
O	SER45
P	SER45

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
O	SER174
P	SER174
M	THR1309
M	THR1513

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P58771

Chain	Residue	Details
O	SER186
O	SER206
O	SER252
O	SER271
P	SER186
P	SER206
P	SER252
P	SER271

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P04692

Chain	Residue	Details
O	TYR261
P	TYR261

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by DAPK1 => ECO:0000269\|PubMed:17895359

Chain	Residue	Details
O	SER283
P	SER283

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P02564

Chain	Residue	Details
M	SER1510

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)