Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8EFH

Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in complex with ADP-Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003774	molecular_function	cytoskeletal motor activity
A	0005524	molecular_function	ATP binding
A	0016459	cellular_component	myosin complex
A	0051015	molecular_function	actin filament binding
B	0001725	cellular_component	stress fiber
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0044297	cellular_component	cell body
B	0048741	biological_process	skeletal muscle fiber development
B	0090131	biological_process	mesenchyme migration
C	0001725	cellular_component	stress fiber
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0044297	cellular_component	cell body
C	0048741	biological_process	skeletal muscle fiber development
C	0090131	biological_process	mesenchyme migration
D	0001725	cellular_component	stress fiber
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0044297	cellular_component	cell body
D	0048741	biological_process	skeletal muscle fiber development
D	0090131	biological_process	mesenchyme migration
E	0001725	cellular_component	stress fiber
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0044297	cellular_component	cell body
E	0048741	biological_process	skeletal muscle fiber development
E	0090131	biological_process	mesenchyme migration
F	0001725	cellular_component	stress fiber
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0044297	cellular_component	cell body
F	0048741	biological_process	skeletal muscle fiber development
F	0090131	biological_process	mesenchyme migration
O	0001725	cellular_component	stress fiber
O	0003065	biological_process	positive regulation of heart rate by epinephrine
O	0003779	molecular_function	actin binding
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005862	cellular_component	muscle thin filament tropomyosin
O	0005884	cellular_component	actin filament
O	0006937	biological_process	regulation of muscle contraction
O	0007010	biological_process	cytoskeleton organization
O	0007015	biological_process	actin filament organization
O	0008016	biological_process	regulation of heart contraction
O	0008092	molecular_function	cytoskeletal protein binding
O	0008307	molecular_function	structural constituent of muscle
O	0008360	biological_process	regulation of cell shape
O	0015629	cellular_component	actin cytoskeleton
O	0030017	cellular_component	sarcomere
O	0030049	biological_process	muscle filament sliding
O	0030336	biological_process	negative regulation of cell migration
O	0031529	biological_process	ruffle organization
O	0032059	cellular_component	bleb
O	0032587	cellular_component	ruffle membrane
O	0032781	biological_process	positive regulation of ATP-dependent activity
O	0034614	biological_process	cellular response to reactive oxygen species
O	0042060	biological_process	wound healing
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0045214	biological_process	sarcomere organization
O	0045785	biological_process	positive regulation of cell adhesion
O	0046982	molecular_function	protein heterodimerization activity
O	0051015	molecular_function	actin filament binding
O	0051496	biological_process	positive regulation of stress fiber assembly
O	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
O	0060048	biological_process	cardiac muscle contraction
O	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
O	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
P	0001725	cellular_component	stress fiber
P	0003065	biological_process	positive regulation of heart rate by epinephrine
P	0003779	molecular_function	actin binding
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005862	cellular_component	muscle thin filament tropomyosin
P	0005884	cellular_component	actin filament
P	0006937	biological_process	regulation of muscle contraction
P	0007010	biological_process	cytoskeleton organization
P	0007015	biological_process	actin filament organization
P	0008016	biological_process	regulation of heart contraction
P	0008092	molecular_function	cytoskeletal protein binding
P	0008307	molecular_function	structural constituent of muscle
P	0008360	biological_process	regulation of cell shape
P	0015629	cellular_component	actin cytoskeleton
P	0030017	cellular_component	sarcomere
P	0030049	biological_process	muscle filament sliding
P	0030336	biological_process	negative regulation of cell migration
P	0031529	biological_process	ruffle organization
P	0032059	cellular_component	bleb
P	0032587	cellular_component	ruffle membrane
P	0032781	biological_process	positive regulation of ATP-dependent activity
P	0034614	biological_process	cellular response to reactive oxygen species
P	0042060	biological_process	wound healing
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0045214	biological_process	sarcomere organization
P	0045785	biological_process	positive regulation of cell adhesion
P	0046982	molecular_function	protein heterodimerization activity
P	0051015	molecular_function	actin filament binding
P	0051496	biological_process	positive regulation of stress fiber assembly
P	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
P	0060048	biological_process	cardiac muscle contraction
P	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
P	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
F	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
F	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
F	LEU104-ARG116

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
O	LEU232-GLU240

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000250\|UniProtKB:P62737

Chain	Residue	Details
C	CYS0
D	CYS0
E	CYS0
F	CYS0
B	CYS0

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: Methionine (R)-sulfoxide => ECO:0000250\|UniProtKB:P68134

Chain	Residue	Details
B	MET44
B	MET47
C	MET44
C	MET47
D	MET44
D	MET47
E	MET44
E	MET47
F	MET44
F	MET47

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: N6-malonyllysine => ECO:0000250

Chain	Residue	Details
C	LYS61
D	LYS61
E	LYS61
F	LYS61
B	LYS61

site_id	SWS_FT_FI4
Number of Residues	5
Details	MOD_RES: Tele-methylhistidine => ECO:0000250\|UniProtKB:P68138

Chain	Residue	Details
P	SER206
P	SER252
P	SER271
F	HIS73
B	HIS73
C	HIS73
D	HIS73
E	HIS73

site_id	SWS_FT_FI5
Number of Residues	5
Details	MOD_RES: N6-methyllysine => ECO:0000250\|UniProtKB:P68133

Chain	Residue	Details
C	LYS84
D	LYS84
E	LYS84
F	LYS84
B	LYS84

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by DAPK1 => ECO:0000269\|PubMed:17895359

Chain	Residue	Details
O	SER283
P	SER283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)