8EEU

Venezuelan equine encephalitis virus-like particle in complex with Fab SKT05

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005198	molecular_function	structural molecule activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019028	cellular_component	viral capsid
A	0019031	cellular_component	viral envelope
A	0019062	biological_process	virion attachment to host cell
A	0020002	cellular_component	host cell plasma membrane
A	0030430	cellular_component	host cell cytoplasm
A	0039619	cellular_component	T=4 icosahedral viral capsid
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0039657	biological_process	symbiont-mediated suppression of host gene expression
A	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
A	0042025	cellular_component	host cell nucleus
A	0046718	biological_process	symbiont entry into host cell
A	0055036	cellular_component	virion membrane
A	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
B	0003723	molecular_function	RNA binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005198	molecular_function	structural molecule activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0019028	cellular_component	viral capsid
B	0019031	cellular_component	viral envelope
B	0019062	biological_process	virion attachment to host cell
B	0020002	cellular_component	host cell plasma membrane
B	0030430	cellular_component	host cell cytoplasm
B	0039619	cellular_component	T=4 icosahedral viral capsid
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
B	0039657	biological_process	symbiont-mediated suppression of host gene expression
B	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
B	0042025	cellular_component	host cell nucleus
B	0046718	biological_process	symbiont entry into host cell
B	0055036	cellular_component	virion membrane
B	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
C	0003723	molecular_function	RNA binding
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005198	molecular_function	structural molecule activity
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0016020	cellular_component	membrane
C	0019028	cellular_component	viral capsid
C	0019031	cellular_component	viral envelope
C	0019062	biological_process	virion attachment to host cell
C	0020002	cellular_component	host cell plasma membrane
C	0030430	cellular_component	host cell cytoplasm
C	0039619	cellular_component	T=4 icosahedral viral capsid
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0039657	biological_process	symbiont-mediated suppression of host gene expression
C	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
C	0042025	cellular_component	host cell nucleus
C	0046718	biological_process	symbiont entry into host cell
C	0055036	cellular_component	virion membrane
C	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
D	0003723	molecular_function	RNA binding
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005198	molecular_function	structural molecule activity
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
D	0016020	cellular_component	membrane
D	0019028	cellular_component	viral capsid
D	0019031	cellular_component	viral envelope
D	0019062	biological_process	virion attachment to host cell
D	0020002	cellular_component	host cell plasma membrane
D	0030430	cellular_component	host cell cytoplasm
D	0039619	cellular_component	T=4 icosahedral viral capsid
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0039657	biological_process	symbiont-mediated suppression of host gene expression
D	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
D	0042025	cellular_component	host cell nucleus
D	0046718	biological_process	symbiont entry into host cell
D	0055036	cellular_component	virion membrane
D	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
E	0003723	molecular_function	RNA binding
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005198	molecular_function	structural molecule activity
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity
E	0016020	cellular_component	membrane
E	0019028	cellular_component	viral capsid
E	0019031	cellular_component	viral envelope
E	0019062	biological_process	virion attachment to host cell
E	0020002	cellular_component	host cell plasma membrane
E	0030430	cellular_component	host cell cytoplasm
E	0039619	cellular_component	T=4 icosahedral viral capsid
E	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
E	0042025	cellular_component	host cell nucleus
E	0046718	biological_process	symbiont entry into host cell
E	0055036	cellular_component	virion membrane
E	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
F	0003723	molecular_function	RNA binding
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005198	molecular_function	structural molecule activity
F	0006508	biological_process	proteolysis
F	0008236	molecular_function	serine-type peptidase activity
F	0016020	cellular_component	membrane
F	0019028	cellular_component	viral capsid
F	0019031	cellular_component	viral envelope
F	0019062	biological_process	virion attachment to host cell
F	0020002	cellular_component	host cell plasma membrane
F	0030430	cellular_component	host cell cytoplasm
F	0039619	cellular_component	T=4 icosahedral viral capsid
F	0039654	biological_process	fusion of virus membrane with host endosome membrane
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
F	0042025	cellular_component	host cell nucleus
F	0046718	biological_process	symbiont entry into host cell
F	0055036	cellular_component	virion membrane
F	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5076
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	SER-536-THR-111
A	GLU-54-GLN-40
A	THR5-SER412
B	SER-58-THR367
B	GLU424-GLN438
B	THR483-SER890
C	SER-536-THR-111
C	GLU-54-GLN-40
C	THR5-SER412
D	SER-58-THR367
D	GLU424-GLN438
D	THR483-SER890
E	SER-536-THR-111
E	GLU-54-GLN-40
E	THR5-SER412
F	SER-58-THR367
F	GLU424-GLN438
F	THR483-SER890

---

site_id	SWS_FT_FI2
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE-110-LEU-90
A	GLN-39-LEU-19
A	VAL-16-ALA4
A	LEU413-MET433
B	ILE368-LEU388
B	GLN439-LEU459
B	VAL462-ALA482
B	LEU891-MET911
C	ILE-110-LEU-90
C	GLN-39-LEU-19
C	VAL-16-ALA4
C	LEU413-MET433
D	ILE368-LEU388
D	GLN439-LEU459
D	VAL462-ALA482
D	LEU891-MET911
E	ILE-110-LEU-90
E	GLN-39-LEU-19
E	VAL-16-ALA4
E	LEU413-MET433
F	ILE368-LEU388
F	GLN439-LEU459
F	VAL462-ALA482
F	LEU891-MET911

---

site_id	SWS_FT_FI3
Number of Residues	258
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	PHE-89-ALA-55
A	ARG-18-CYS-17
A	TYR434-ASN442
B	PHE389-ALA423
B	ARG460-CYS461
B	TYR912-ASN920
C	PHE-89-ALA-55
C	ARG-18-CYS-17
C	TYR434-ASN442
D	PHE389-ALA423
D	ARG460-CYS461
D	TYR912-ASN920
E	PHE-89-ALA-55
E	ARG-18-CYS-17
E	TYR434-ASN442
F	PHE389-ALA423
F	ARG460-CYS461
F	TYR912-ASN920

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01027

Chain	Residue	Details
A	HIS-660
A	ASP-638
A	SER-586
B	HIS-182
B	ASP-160
B	SER-108
C	HIS-660
C	ASP-638
C	SER-586
D	HIS-182
D	ASP-160
D	SER-108
E	HIS-660
E	ASP-638
E	SER-586
F	HIS-182
F	ASP-160
F	SER-108

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	SITE: Involved in dimerization of the capsid protein => ECO:0000250|UniProtKB:Q86925

Chain	Residue	Details
A	TYR-612
A	ASN-579
B	TYR-134
B	ASN-101
C	TYR-612
C	ASN-579
D	TYR-134
D	ASN-101
E	TYR-612
E	ASN-579
F	TYR-134
F	ASN-101

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P03315

Chain	Residue	Details
A	TRP-537
B	TRP-59
C	TRP-537
D	TRP-59
E	TRP-537
F	TRP-59

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	SITE: Cleavage; by host signal peptidase => ECO:0000250

Chain	Residue	Details
A	ALA-55
A	ALA0
B	ALA423
B	ALA478
C	ALA-55
C	ALA0
D	ALA423
D	ALA478
E	ALA-55
E	ALA0
F	ALA423
F	ALA478

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P09592

Chain	Residue	Details
A	THR-719
A	THR-704
A	THR-685
B	THR-241
B	THR-226
B	THR-207
C	THR-719
C	THR-704
C	THR-685
D	THR-241
D	THR-226
D	THR-207
E	THR-719
E	THR-704
E	THR-685
F	THR-241
F	THR-226
F	THR-207

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09592

Chain	Residue	Details
A	SER-688
B	SER-210
C	SER-688
D	SER-210
E	SER-688
F	SER-210

---

site_id	SWS_FT_FI10
Number of Residues	18
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000250

Chain	Residue	Details
A	CYS-82
A	CYS-62
A	CYS-61
B	CYS396
B	CYS416
B	CYS417
C	CYS-82
C	CYS-62
C	CYS-61
D	CYS396
D	CYS416
D	CYS417
E	CYS-82
E	CYS-62
E	CYS-61
F	CYS396
F	CYS416
F	CYS417

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
A	ASN-526
A	ASN-266
A	ASN-160
A	ASN134
B	ASN-48
B	ASN212
B	ASN318
B	ASN612
C	ASN-526
C	ASN-266
C	ASN-160
C	ASN134
D	ASN-48
D	ASN212
D	ASN318
D	ASN612
E	ASN-526
E	ASN-266
E	ASN-160
E	ASN134
F	ASN-48
F	ASN212
F	ASN318
F	ASN612

---