8E4Y

Cryo-EM structure of human glycerol-3-phosphate acyltransferase 1 (GPAT1) in complex with 2-oxohexadecyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001817	biological_process	regulation of cytokine production
A	0004366	molecular_function	glycerol-3-phosphate O-acyltransferase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005886	cellular_component	plasma membrane
A	0006072	biological_process	glycerol-3-phosphate metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0006641	biological_process	triglyceride metabolic process
A	0006650	biological_process	glycerophospholipid metabolic process
A	0006651	biological_process	diacylglycerol biosynthetic process
A	0006654	biological_process	phosphatidic acid biosynthetic process
A	0006655	biological_process	phosphatidylglycerol biosynthetic process
A	0006924	biological_process	activation-induced cell death of T cells
A	0008374	molecular_function	O-acyltransferase activity
A	0008654	biological_process	phospholipid biosynthetic process
A	0009749	biological_process	response to glucose
A	0016024	biological_process	CDP-diacylglycerol biosynthetic process
A	0016746	molecular_function	acyltransferase activity
A	0019432	biological_process	triglyceride biosynthetic process
A	0031966	cellular_component	mitochondrial membrane
A	0040018	biological_process	positive regulation of multicellular organism growth
A	0042104	biological_process	positive regulation of activated T cell proliferation
A	0044255	biological_process	cellular lipid metabolic process
A	0050798	biological_process	activated T cell proliferation
A	0051607	biological_process	defense response to virus
A	0055089	biological_process	fatty acid homeostasis
A	0055091	biological_process	phospholipid homeostasis
A	0070236	biological_process	negative regulation of activation-induced cell death of T cells
A	0102420	molecular_function	sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE472-TYR494
A	GLY575-VAL593

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site_id	SWS_FT_FI2
Number of Residues	79
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	ARG495-ASN574

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site_id	SWS_FT_FI3
Number of Residues	234
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000255

Chain	Residue	Details
A	LEU594-LEU828

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97564

Chain	Residue	Details
A	SER380

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q61586

Chain	Residue	Details
A	SER688

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER695

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q61586

Chain	Residue	Details
A	LYS780
A	LYS784

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