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8DPW

The structure of Interleukin-11 Mutein

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005142molecular_functioninterleukin-11 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0030183biological_processB cell differentiation
A0030219biological_processmegakaryocyte differentiation
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0038154biological_processinterleukin-11-mediated signaling pathway
A0043410biological_processpositive regulation of MAPK cascade
A0045444biological_processfat cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046888biological_processnegative regulation of hormone secretion
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A1903659biological_processregulation of complement-dependent cytotoxicity
A2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue SO4 A 201
ChainResidue
ASER11
AHOH338

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Important for interaction with IL6ST and for the stimulation of cell proliferation => ECO:0000250|UniProtKB:P47873
ChainResidueDetails
AALA147

219869

PDB entries from 2024-05-15

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