Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DD0

The structure of the native cardiac thin filament junction region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001725	cellular_component	stress fiber
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0030027	cellular_component	lamellipodium
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0044297	cellular_component	cell body
A	0048741	biological_process	skeletal muscle fiber development
A	0090131	biological_process	mesenchyme migration
B	0001725	cellular_component	stress fiber
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0044297	cellular_component	cell body
B	0048741	biological_process	skeletal muscle fiber development
B	0090131	biological_process	mesenchyme migration
C	0001725	cellular_component	stress fiber
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0044297	cellular_component	cell body
C	0048741	biological_process	skeletal muscle fiber development
C	0090131	biological_process	mesenchyme migration
D	0001725	cellular_component	stress fiber
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0044297	cellular_component	cell body
D	0048741	biological_process	skeletal muscle fiber development
D	0090131	biological_process	mesenchyme migration
E	0001725	cellular_component	stress fiber
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0044297	cellular_component	cell body
E	0048741	biological_process	skeletal muscle fiber development
E	0090131	biological_process	mesenchyme migration
F	0001725	cellular_component	stress fiber
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0044297	cellular_component	cell body
F	0048741	biological_process	skeletal muscle fiber development
F	0090131	biological_process	mesenchyme migration
G	0003779	molecular_function	actin binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005884	cellular_component	actin filament
G	0007015	biological_process	actin filament organization
G	0015629	cellular_component	actin cytoskeleton
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0046982	molecular_function	protein heterodimerization activity
G	0051015	molecular_function	actin filament binding
G	0060048	biological_process	cardiac muscle contraction
H	0003779	molecular_function	actin binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0007015	biological_process	actin filament organization
H	0015629	cellular_component	actin cytoskeleton
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0046982	molecular_function	protein heterodimerization activity
H	0051015	molecular_function	actin filament binding
H	0060048	biological_process	cardiac muscle contraction
I	0003779	molecular_function	actin binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0007015	biological_process	actin filament organization
I	0015629	cellular_component	actin cytoskeleton
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0046982	molecular_function	protein heterodimerization activity
I	0051015	molecular_function	actin filament binding
I	0060048	biological_process	cardiac muscle contraction
J	0003779	molecular_function	actin binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0007015	biological_process	actin filament organization
J	0015629	cellular_component	actin cytoskeleton
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0046982	molecular_function	protein heterodimerization activity
J	0051015	molecular_function	actin filament binding
J	0060048	biological_process	cardiac muscle contraction
K	0003779	molecular_function	actin binding
K	0005523	molecular_function	tropomyosin binding
K	0005861	cellular_component	troponin complex
K	0005865	cellular_component	striated muscle thin filament
K	0006937	biological_process	regulation of muscle contraction
K	0008016	biological_process	regulation of heart contraction
K	0030049	biological_process	muscle filament sliding
K	0030172	molecular_function	troponin C binding
K	0031013	molecular_function	troponin I binding
K	0045214	biological_process	sarcomere organization
K	0051592	biological_process	response to calcium ion
K	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
K	0060048	biological_process	cardiac muscle contraction
K	0097512	cellular_component	cardiac myofibril
K	1990584	cellular_component	cardiac Troponin complex
L	0003779	molecular_function	actin binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005884	cellular_component	actin filament
L	0007015	biological_process	actin filament organization
L	0015629	cellular_component	actin cytoskeleton
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0046982	molecular_function	protein heterodimerization activity
L	0051015	molecular_function	actin filament binding
L	0060048	biological_process	cardiac muscle contraction
M	0003779	molecular_function	actin binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005884	cellular_component	actin filament
M	0007015	biological_process	actin filament organization
M	0015629	cellular_component	actin cytoskeleton
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0046982	molecular_function	protein heterodimerization activity
M	0051015	molecular_function	actin filament binding
M	0060048	biological_process	cardiac muscle contraction
N	0003779	molecular_function	actin binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005884	cellular_component	actin filament
N	0007015	biological_process	actin filament organization
N	0015629	cellular_component	actin cytoskeleton
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0046982	molecular_function	protein heterodimerization activity
N	0051015	molecular_function	actin filament binding
N	0060048	biological_process	cardiac muscle contraction
O	0003779	molecular_function	actin binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005884	cellular_component	actin filament
O	0007015	biological_process	actin filament organization
O	0015629	cellular_component	actin cytoskeleton
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0046982	molecular_function	protein heterodimerization activity
O	0051015	molecular_function	actin filament binding
O	0060048	biological_process	cardiac muscle contraction
P	0003779	molecular_function	actin binding
P	0005523	molecular_function	tropomyosin binding
P	0005861	cellular_component	troponin complex
P	0005865	cellular_component	striated muscle thin filament
P	0006937	biological_process	regulation of muscle contraction
P	0008016	biological_process	regulation of heart contraction
P	0030049	biological_process	muscle filament sliding
P	0030172	molecular_function	troponin C binding
P	0031013	molecular_function	troponin I binding
P	0045214	biological_process	sarcomere organization
P	0051592	biological_process	response to calcium ion
P	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
P	0060048	biological_process	cardiac muscle contraction
P	0097512	cellular_component	cardiac myofibril
P	1990584	cellular_component	cardiac Troponin complex

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
G	LEU232-GLU240

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N-acetylcysteine; in intermediate form => ECO:0000250\|UniProtKB:P62737

Chain	Residue	Details
N	MET1
O	MET1
E	CYS0
F	CYS0
A	CYS0
B	CYS0
C	CYS0
D	CYS0

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Methionine (R)-sulfoxide => ECO:0000250\|UniProtKB:P68134

Chain	Residue	Details
B	MET47
C	MET44
C	MET47
E	MET44
D	MET44
E	MET47
F	MET44
F	MET47
D	MET47
A	MET44
A	MET47
B	MET44

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-malonyllysine => ECO:0000250

Chain	Residue	Details
D	LYS61
N	SER174
O	SER174
E	LYS61
F	LYS61
A	LYS61
B	LYS61
C	LYS61

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Tele-methylhistidine => ECO:0000250\|UniProtKB:P68138

Chain	Residue	Details
H	SER252
H	SER271
I	SER186
I	SER206
I	SER252
I	SER271
J	SER186
J	SER206
J	SER252
J	SER271
L	SER186
L	SER206
L	SER252
L	SER271
M	SER186
M	SER206
M	SER252
M	SER271
N	SER186
N	SER206
N	SER252
N	SER271
O	SER186
O	SER206
O	SER252
O	SER271
E	HIS73
A	HIS73
B	HIS73
C	HIS73
D	HIS73
F	HIS73

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-methyllysine => ECO:0000250\|UniProtKB:P68133

Chain	Residue	Details
N	TYR261
O	TYR261
D	LYS84
E	LYS84
F	LYS84
A	LYS84
B	LYS84
C	LYS84

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine; by DAPK1 => ECO:0000250\|UniProtKB:P09493

Chain	Residue	Details
G	SER283
H	SER283
I	SER283
J	SER283
L	SER283
M	SER283
N	SER283
O	SER283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)