8DBI

Human PRPS1 with Phosphate, ATP, and R5P; Hexamer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002189	cellular_component	ribose phosphate diphosphokinase complex
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0006144	biological_process	purine nucleobase metabolic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0007399	biological_process	nervous system development
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0034418	biological_process	urate biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044249	biological_process	cellular biosynthetic process
A	0046101	biological_process	hypoxanthine biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0090407	biological_process	organophosphate biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0002189	cellular_component	ribose phosphate diphosphokinase complex
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
B	0006144	biological_process	purine nucleobase metabolic process
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0007399	biological_process	nervous system development
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0034418	biological_process	urate biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044249	biological_process	cellular biosynthetic process
B	0046101	biological_process	hypoxanthine biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0090407	biological_process	organophosphate biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0002189	cellular_component	ribose phosphate diphosphokinase complex
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
C	0006144	biological_process	purine nucleobase metabolic process
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0007399	biological_process	nervous system development
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0034418	biological_process	urate biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044249	biological_process	cellular biosynthetic process
C	0046101	biological_process	hypoxanthine biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0090407	biological_process	organophosphate biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0002189	cellular_component	ribose phosphate diphosphokinase complex
D	0004749	molecular_function	ribose phosphate diphosphokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
D	0006144	biological_process	purine nucleobase metabolic process
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0007399	biological_process	nervous system development
D	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0016301	molecular_function	kinase activity
D	0034418	biological_process	urate biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044249	biological_process	cellular biosynthetic process
D	0046101	biological_process	hypoxanthine biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0090407	biological_process	organophosphate biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0002189	cellular_component	ribose phosphate diphosphokinase complex
E	0004749	molecular_function	ribose phosphate diphosphokinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
E	0006144	biological_process	purine nucleobase metabolic process
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006796	biological_process	phosphate-containing compound metabolic process
E	0007399	biological_process	nervous system development
E	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
E	0009165	biological_process	nucleotide biosynthetic process
E	0016301	molecular_function	kinase activity
E	0034418	biological_process	urate biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0044249	biological_process	cellular biosynthetic process
E	0046101	biological_process	hypoxanthine biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0090407	biological_process	organophosphate biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0002189	cellular_component	ribose phosphate diphosphokinase complex
F	0004749	molecular_function	ribose phosphate diphosphokinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
F	0006144	biological_process	purine nucleobase metabolic process
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006796	biological_process	phosphate-containing compound metabolic process
F	0007399	biological_process	nervous system development
F	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
F	0009165	biological_process	nucleotide biosynthetic process
F	0016301	molecular_function	kinase activity
F	0034418	biological_process	urate biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044249	biological_process	cellular biosynthetic process
F	0046101	biological_process	hypoxanthine biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0090407	biological_process	organophosphate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAsQIQGFFdiPVD

Chain	Residue	Details
A	ASP128-ASP143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	ARG96
B	ARG96
C	ARG96
D	ARG96
E	ARG96
F	ARG96

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site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	ASP128
A	HIS130
A	ASP139
A	ASP143
B	ASP128
B	HIS130
B	ASP139
B	ASP143
C	ASP128
C	HIS130
C	ASP139
C	ASP143
D	ASP128
D	HIS130
D	ASP139
D	ASP143
E	ASP128
E	HIS130
E	ASP139
E	ASP143
F	ASP128
F	HIS130
F	ASP139
F	ASP143

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