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8D4F

beta-Arf1 mediated dimeric assembly of AP-1, Arf1, Nef complex within lattice on MHC-I lipopeptide incorporated wide(r) membrane tubes

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001822biological_processkidney development
A0005515molecular_functionprotein binding
A0005765cellular_componentlysosomal membrane
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0007368biological_processdetermination of left/right symmetry
A0007507biological_processheart development
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0019901molecular_functionprotein kinase binding
A0030117cellular_componentmembrane coat
A0030121cellular_componentAP-1 adaptor complex
A0030131cellular_componentclathrin adaptor complex
A0030276molecular_functionclathrin binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030665cellular_componentclathrin-coated vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032588cellular_componenttrans-Golgi network membrane
A0043231cellular_componentintracellular membrane-bounded organelle
A0060155biological_processplatelet dense granule organization
A0110010biological_processbasolateral protein secretion
A1903232biological_processmelanosome assembly
B0000139cellular_componentGolgi membrane
B0001822biological_processkidney development
B0005515molecular_functionprotein binding
B0005765cellular_componentlysosomal membrane
B0005769cellular_componentearly endosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0007368biological_processdetermination of left/right symmetry
B0007507biological_processheart development
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
B0019901molecular_functionprotein kinase binding
B0030117cellular_componentmembrane coat
B0030121cellular_componentAP-1 adaptor complex
B0030131cellular_componentclathrin adaptor complex
B0030276molecular_functionclathrin binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030665cellular_componentclathrin-coated vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032588cellular_componenttrans-Golgi network membrane
B0043231cellular_componentintracellular membrane-bounded organelle
B0060155biological_processplatelet dense granule organization
B0110010biological_processbasolateral protein secretion
B1903232biological_processmelanosome assembly
C0000139cellular_componentGolgi membrane
C0000287molecular_functionmagnesium ion binding
C0002090biological_processregulation of receptor internalization
C0003723molecular_functionRNA binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006878biological_processintracellular copper ion homeostasis
C0006886biological_processintracellular protein transport
C0012505cellular_componentendomembrane system
C0014069cellular_componentpostsynaptic density
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0016192biological_processvesicle-mediated transport
C0016787molecular_functionhydrolase activity
C0019904molecular_functionprotein domain specific binding
C0030017cellular_componentsarcomere
C0031252cellular_componentcell leading edge
C0032991cellular_componentprotein-containing complex
C0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0060292biological_processlong-term synaptic depression
C0070062cellular_componentextracellular exosome
C0097061biological_processdendritic spine organization
C0098586biological_processcellular response to virus
C1990386biological_processmitotic cleavage furrow ingression
D0000139cellular_componentGolgi membrane
D0000287molecular_functionmagnesium ion binding
D0002090biological_processregulation of receptor internalization
D0003723molecular_functionRNA binding
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006878biological_processintracellular copper ion homeostasis
D0006886biological_processintracellular protein transport
D0012505cellular_componentendomembrane system
D0014069cellular_componentpostsynaptic density
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016192biological_processvesicle-mediated transport
D0016787molecular_functionhydrolase activity
D0019904molecular_functionprotein domain specific binding
D0030017cellular_componentsarcomere
D0031252cellular_componentcell leading edge
D0032991cellular_componentprotein-containing complex
D0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0060292biological_processlong-term synaptic depression
D0070062cellular_componentextracellular exosome
D0097061biological_processdendritic spine organization
D0098586biological_processcellular response to virus
D1990386biological_processmitotic cleavage furrow ingression
E0006886biological_processintracellular protein transport
E0016192biological_processvesicle-mediated transport
E0030117cellular_componentmembrane coat
F0000139cellular_componentGolgi membrane
F0000287molecular_functionmagnesium ion binding
F0002090biological_processregulation of receptor internalization
F0003723molecular_functionRNA binding
F0003924molecular_functionGTPase activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006878biological_processintracellular copper ion homeostasis
F0006886biological_processintracellular protein transport
F0012505cellular_componentendomembrane system
F0014069cellular_componentpostsynaptic density
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0016192biological_processvesicle-mediated transport
F0016787molecular_functionhydrolase activity
F0019904molecular_functionprotein domain specific binding
F0030017cellular_componentsarcomere
F0031252cellular_componentcell leading edge
F0032991cellular_componentprotein-containing complex
F0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
F0043005cellular_componentneuron projection
F0045202cellular_componentsynapse
F0060292biological_processlong-term synaptic depression
F0070062cellular_componentextracellular exosome
F0097061biological_processdendritic spine organization
F0098586biological_processcellular response to virus
F1990386biological_processmitotic cleavage furrow ingression
G0006886biological_processintracellular protein transport
G0016192biological_processvesicle-mediated transport
G0030117cellular_componentmembrane coat
H0000139cellular_componentGolgi membrane
H0000287molecular_functionmagnesium ion binding
H0002090biological_processregulation of receptor internalization
H0003723molecular_functionRNA binding
H0003924molecular_functionGTPase activity
H0005515molecular_functionprotein binding
H0005525molecular_functionGTP binding
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005925cellular_componentfocal adhesion
H0006878biological_processintracellular copper ion homeostasis
H0006886biological_processintracellular protein transport
H0012505cellular_componentendomembrane system
H0014069cellular_componentpostsynaptic density
H0015031biological_processprotein transport
H0016020cellular_componentmembrane
H0016192biological_processvesicle-mediated transport
H0016787molecular_functionhydrolase activity
H0019904molecular_functionprotein domain specific binding
H0030017cellular_componentsarcomere
H0031252cellular_componentcell leading edge
H0032991cellular_componentprotein-containing complex
H0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
H0043005cellular_componentneuron projection
H0045202cellular_componentsynapse
H0060292biological_processlong-term synaptic depression
H0070062cellular_componentextracellular exosome
H0097061biological_processdendritic spine organization
H0098586biological_processcellular response to virus
H1990386biological_processmitotic cleavage furrow ingression
I0005102molecular_functionsignaling receptor binding
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005576cellular_componentextracellular region
I0006915biological_processapoptotic process
I0016020cellular_componentmembrane
I0017124molecular_functionSH3 domain binding
I0019049biological_processvirus-mediated perturbation of host defense response
I0019058biological_processviral life cycle
I0019901molecular_functionprotein kinase binding
I0020002cellular_componenthost cell plasma membrane
I0031996molecular_functionthioesterase binding
I0033668biological_processsymbiont-mediated suppression of host apoptosis
I0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
I0039521biological_processsuppression by virus of host autophagy
I0042288molecular_functionMHC class I protein binding
I0042609molecular_functionCD4 receptor binding
I0044177cellular_componenthost cell Golgi apparatus
I0044178cellular_componenthost cell Golgi membrane
I0044423cellular_componentvirion component
I0045225biological_processnegative regulation of CD4 production
I0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
I0050848biological_processregulation of calcium-mediated signaling
I0051117molecular_functionATPase binding
I0070206biological_processprotein trimerization
I0075528biological_processperturbation by virus of host immune response
J0005515molecular_functionprotein binding
J0005765cellular_componentlysosomal membrane
J0005769cellular_componentearly endosome
J0005794cellular_componentGolgi apparatus
J0005802cellular_componenttrans-Golgi network
J0005829cellular_componentcytosol
J0006886biological_processintracellular protein transport
J0015031biological_processprotein transport
J0016020cellular_componentmembrane
J0016192biological_processvesicle-mediated transport
J0030121cellular_componentAP-1 adaptor complex
J0030131cellular_componentclathrin adaptor complex
J0030136cellular_componentclathrin-coated vesicle
J0030665cellular_componentclathrin-coated vesicle membrane
J0031410cellular_componentcytoplasmic vesicle
J0032438biological_processmelanosome organization
J0032588cellular_componenttrans-Golgi network membrane
J0035615molecular_functionclathrin adaptor activity
J0035646biological_processendosome to melanosome transport
J0043231cellular_componentintracellular membrane-bounded organelle
J0045202cellular_componentsynapse
J0051649biological_processestablishment of localization in cell
J0060155biological_processplatelet dense granule organization
J1903232biological_processmelanosome assembly
K0005102molecular_functionsignaling receptor binding
K0005515molecular_functionprotein binding
K0005525molecular_functionGTP binding
K0005576cellular_componentextracellular region
K0006915biological_processapoptotic process
K0016020cellular_componentmembrane
K0017124molecular_functionSH3 domain binding
K0019049biological_processvirus-mediated perturbation of host defense response
K0019058biological_processviral life cycle
K0019901molecular_functionprotein kinase binding
K0020002cellular_componenthost cell plasma membrane
K0031996molecular_functionthioesterase binding
K0033668biological_processsymbiont-mediated suppression of host apoptosis
K0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
K0039521biological_processsuppression by virus of host autophagy
K0042288molecular_functionMHC class I protein binding
K0042609molecular_functionCD4 receptor binding
K0044177cellular_componenthost cell Golgi apparatus
K0044178cellular_componenthost cell Golgi membrane
K0044423cellular_componentvirion component
K0045225biological_processnegative regulation of CD4 production
K0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
K0050848biological_processregulation of calcium-mediated signaling
K0051117molecular_functionATPase binding
K0070206biological_processprotein trimerization
K0075528biological_processperturbation by virus of host immune response
L0005102molecular_functionsignaling receptor binding
L0005515molecular_functionprotein binding
L0005525molecular_functionGTP binding
L0005576cellular_componentextracellular region
L0006915biological_processapoptotic process
L0016020cellular_componentmembrane
L0017124molecular_functionSH3 domain binding
L0019049biological_processvirus-mediated perturbation of host defense response
L0019058biological_processviral life cycle
L0019901molecular_functionprotein kinase binding
L0020002cellular_componenthost cell plasma membrane
L0031996molecular_functionthioesterase binding
L0033668biological_processsymbiont-mediated suppression of host apoptosis
L0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
L0039521biological_processsuppression by virus of host autophagy
L0042288molecular_functionMHC class I protein binding
L0042609molecular_functionCD4 receptor binding
L0044177cellular_componenthost cell Golgi apparatus
L0044178cellular_componenthost cell Golgi membrane
L0044423cellular_componentvirion component
L0045225biological_processnegative regulation of CD4 production
L0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
L0050848biological_processregulation of calcium-mediated signaling
L0051117molecular_functionATPase binding
L0070206biological_processprotein trimerization
L0075528biological_processperturbation by virus of host immune response
M0005515molecular_functionprotein binding
M0005765cellular_componentlysosomal membrane
M0005769cellular_componentearly endosome
M0005794cellular_componentGolgi apparatus
M0005802cellular_componenttrans-Golgi network
M0005829cellular_componentcytosol
M0006886biological_processintracellular protein transport
M0015031biological_processprotein transport
M0016020cellular_componentmembrane
M0016192biological_processvesicle-mediated transport
M0030121cellular_componentAP-1 adaptor complex
M0030131cellular_componentclathrin adaptor complex
M0030136cellular_componentclathrin-coated vesicle
M0030665cellular_componentclathrin-coated vesicle membrane
M0031410cellular_componentcytoplasmic vesicle
M0032438biological_processmelanosome organization
M0032588cellular_componenttrans-Golgi network membrane
M0035615molecular_functionclathrin adaptor activity
M0035646biological_processendosome to melanosome transport
M0043231cellular_componentintracellular membrane-bounded organelle
M0045202cellular_componentsynapse
M0051649biological_processestablishment of localization in cell
M0060155biological_processplatelet dense granule organization
M1903232biological_processmelanosome assembly
N0005102molecular_functionsignaling receptor binding
N0005515molecular_functionprotein binding
N0005525molecular_functionGTP binding
N0005576cellular_componentextracellular region
N0006915biological_processapoptotic process
N0016020cellular_componentmembrane
N0017124molecular_functionSH3 domain binding
N0019049biological_processvirus-mediated perturbation of host defense response
N0019058biological_processviral life cycle
N0019901molecular_functionprotein kinase binding
N0020002cellular_componenthost cell plasma membrane
N0031996molecular_functionthioesterase binding
N0033668biological_processsymbiont-mediated suppression of host apoptosis
N0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
N0039521biological_processsuppression by virus of host autophagy
N0042288molecular_functionMHC class I protein binding
N0042609molecular_functionCD4 receptor binding
N0044177cellular_componenthost cell Golgi apparatus
N0044178cellular_componenthost cell Golgi membrane
N0044423cellular_componentvirion component
N0045225biological_processnegative regulation of CD4 production
N0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
N0050848biological_processregulation of calcium-mediated signaling
N0051117molecular_functionATPase binding
N0070206biological_processprotein trimerization
N0075528biological_processperturbation by virus of host immune response
O0000139cellular_componentGolgi membrane
O0005515molecular_functionprotein binding
O0005765cellular_componentlysosomal membrane
O0005769cellular_componentearly endosome
O0005794cellular_componentGolgi apparatus
O0005829cellular_componentcytosol
O0005905cellular_componentclathrin-coated pit
O0006605biological_processprotein targeting
O0006886biological_processintracellular protein transport
O0015031biological_processprotein transport
O0016192biological_processvesicle-mediated transport
O0030117cellular_componentmembrane coat
O0030121cellular_componentAP-1 adaptor complex
O0030659cellular_componentcytoplasmic vesicle membrane
O0031410cellular_componentcytoplasmic vesicle
O0032588cellular_componenttrans-Golgi network membrane
O0035615molecular_functionclathrin adaptor activity
O0043231cellular_componentintracellular membrane-bounded organelle
O0060155biological_processplatelet dense granule organization
O1903232biological_processmelanosome assembly
P0006955biological_processimmune response
P0019882biological_processantigen processing and presentation
Q0000139cellular_componentGolgi membrane
Q0000287molecular_functionmagnesium ion binding
Q0002090biological_processregulation of receptor internalization
Q0003723molecular_functionRNA binding
Q0003924molecular_functionGTPase activity
Q0005515molecular_functionprotein binding
Q0005525molecular_functionGTP binding
Q0005794cellular_componentGolgi apparatus
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0005925cellular_componentfocal adhesion
Q0006878biological_processintracellular copper ion homeostasis
Q0006886biological_processintracellular protein transport
Q0012505cellular_componentendomembrane system
Q0014069cellular_componentpostsynaptic density
Q0015031biological_processprotein transport
Q0016020cellular_componentmembrane
Q0016192biological_processvesicle-mediated transport
Q0016787molecular_functionhydrolase activity
Q0019904molecular_functionprotein domain specific binding
Q0030017cellular_componentsarcomere
Q0031252cellular_componentcell leading edge
Q0032991cellular_componentprotein-containing complex
Q0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
Q0043005cellular_componentneuron projection
Q0045202cellular_componentsynapse
Q0060292biological_processlong-term synaptic depression
Q0070062cellular_componentextracellular exosome
Q0097061biological_processdendritic spine organization
Q0098586biological_processcellular response to virus
Q1990386biological_processmitotic cleavage furrow ingression
S0000139cellular_componentGolgi membrane
S0005515molecular_functionprotein binding
S0005765cellular_componentlysosomal membrane
S0005769cellular_componentearly endosome
S0005794cellular_componentGolgi apparatus
S0005829cellular_componentcytosol
S0005905cellular_componentclathrin-coated pit
S0006605biological_processprotein targeting
S0006886biological_processintracellular protein transport
S0015031biological_processprotein transport
S0016192biological_processvesicle-mediated transport
S0030117cellular_componentmembrane coat
S0030121cellular_componentAP-1 adaptor complex
S0030659cellular_componentcytoplasmic vesicle membrane
S0031410cellular_componentcytoplasmic vesicle
S0032588cellular_componenttrans-Golgi network membrane
S0035615molecular_functionclathrin adaptor activity
S0043231cellular_componentintracellular membrane-bounded organelle
S0060155biological_processplatelet dense granule organization
S1903232biological_processmelanosome assembly
Y0006955biological_processimmune response
Y0019882biological_processantigen processing and presentation
Z0000139cellular_componentGolgi membrane
Z0000287molecular_functionmagnesium ion binding
Z0002090biological_processregulation of receptor internalization
Z0003723molecular_functionRNA binding
Z0003924molecular_functionGTPase activity
Z0005515molecular_functionprotein binding
Z0005525molecular_functionGTP binding
Z0005794cellular_componentGolgi apparatus
Z0005829cellular_componentcytosol
Z0005886cellular_componentplasma membrane
Z0005925cellular_componentfocal adhesion
Z0006878biological_processintracellular copper ion homeostasis
Z0006886biological_processintracellular protein transport
Z0012505cellular_componentendomembrane system
Z0014069cellular_componentpostsynaptic density
Z0015031biological_processprotein transport
Z0016020cellular_componentmembrane
Z0016192biological_processvesicle-mediated transport
Z0016787molecular_functionhydrolase activity
Z0019904molecular_functionprotein domain specific binding
Z0030017cellular_componentsarcomere
Z0031252cellular_componentcell leading edge
Z0032991cellular_componentprotein-containing complex
Z0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
Z0043005cellular_componentneuron projection
Z0045202cellular_componentsynapse
Z0060292biological_processlong-term synaptic depression
Z0070062cellular_componentextracellular exosome
Z0097061biological_processdendritic spine organization
Z0098586biological_processcellular response to virus
Z1990386biological_processmitotic cleavage furrow ingression
Functional Information from PROSITE/UniProt
site_idPS00989
Number of Residues11
DetailsCLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LVYKryasLYF
ChainResidueDetails
SLEU57-PHE67

site_idPS00990
Number of Residues21
DetailsCLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. VSWRse.GikYrkNeVFLDVIE
ChainResidueDetails
MVAL157-GLU177

site_idPS00991
Number of Residues15
DetailsCLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY
ChainResidueDetails
MILE253-TYR267

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
YSER343
YGLY349
YSER350
YSER352
PSER343
PGLY349
PSER350
PSER352

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
YTYR344
PTYR344
JTHR152
JTHR154
FASN126
QASN126

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
YSER356
YSER359
PSER356
PSER359
FALA160
QALA160

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N-acetylglycine; alternate => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
CGLY2
HGLY2
ZGLY2
DGLY2
FGLY2
QGLY2

site_idSWS_FT_FI5
Number of Residues6
DetailsLIPID: N-myristoyl glycine; alternate => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:23535599, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930
ChainResidueDetails
CGLY2
HGLY2
ZGLY2
DGLY2
FGLY2
QGLY2

219869

PDB entries from 2024-05-15

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