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8D44

Cryo-electron microscopy structure of human kidney Fructose-bisphosphate aldolase B

Functional Information from GO Data
ChainGOidnamespacecontents
A0004332molecular_functionfructose-bisphosphate aldolase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005815cellular_componentmicrotubule organizing center
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006000biological_processfructose metabolic process
A0006001biological_processfructose catabolic process
A0006094biological_processgluconeogenesis
A0006096biological_processglycolytic process
A0006116biological_processNADH oxidation
A0008092molecular_functioncytoskeletal protein binding
A0016829molecular_functionlyase activity
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0032781biological_processpositive regulation of ATP-dependent activity
A0034451cellular_componentcentriolar satellite
A0042802molecular_functionidentical protein binding
A0051117molecular_functionATPase binding
A0060090molecular_functionmolecular adaptor activity
A0061609molecular_functionfructose-1-phosphate aldolase activity
A0061624biological_processfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
A0070061molecular_functionfructose binding
A0070062cellular_componentextracellular exosome
A0070072biological_processvacuolar proton-transporting V-type ATPase complex assembly
A1905856biological_processnegative regulation of pentose-phosphate shunt
B0004332molecular_functionfructose-bisphosphate aldolase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005815cellular_componentmicrotubule organizing center
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006000biological_processfructose metabolic process
B0006001biological_processfructose catabolic process
B0006094biological_processgluconeogenesis
B0006096biological_processglycolytic process
B0006116biological_processNADH oxidation
B0008092molecular_functioncytoskeletal protein binding
B0016829molecular_functionlyase activity
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0032781biological_processpositive regulation of ATP-dependent activity
B0034451cellular_componentcentriolar satellite
B0042802molecular_functionidentical protein binding
B0051117molecular_functionATPase binding
B0060090molecular_functionmolecular adaptor activity
B0061609molecular_functionfructose-1-phosphate aldolase activity
B0061624biological_processfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
B0070061molecular_functionfructose binding
B0070062cellular_componentextracellular exosome
B0070072biological_processvacuolar proton-transporting V-type ATPase complex assembly
B1905856biological_processnegative regulation of pentose-phosphate shunt
C0004332molecular_functionfructose-bisphosphate aldolase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005815cellular_componentmicrotubule organizing center
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006000biological_processfructose metabolic process
C0006001biological_processfructose catabolic process
C0006094biological_processgluconeogenesis
C0006096biological_processglycolytic process
C0006116biological_processNADH oxidation
C0008092molecular_functioncytoskeletal protein binding
C0016829molecular_functionlyase activity
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0032781biological_processpositive regulation of ATP-dependent activity
C0034451cellular_componentcentriolar satellite
C0042802molecular_functionidentical protein binding
C0051117molecular_functionATPase binding
C0060090molecular_functionmolecular adaptor activity
C0061609molecular_functionfructose-1-phosphate aldolase activity
C0061624biological_processfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
C0070061molecular_functionfructose binding
C0070062cellular_componentextracellular exosome
C0070072biological_processvacuolar proton-transporting V-type ATPase complex assembly
C1905856biological_processnegative regulation of pentose-phosphate shunt
D0004332molecular_functionfructose-bisphosphate aldolase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005815cellular_componentmicrotubule organizing center
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0006000biological_processfructose metabolic process
D0006001biological_processfructose catabolic process
D0006094biological_processgluconeogenesis
D0006096biological_processglycolytic process
D0006116biological_processNADH oxidation
D0008092molecular_functioncytoskeletal protein binding
D0016829molecular_functionlyase activity
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0032781biological_processpositive regulation of ATP-dependent activity
D0034451cellular_componentcentriolar satellite
D0042802molecular_functionidentical protein binding
D0051117molecular_functionATPase binding
D0060090molecular_functionmolecular adaptor activity
D0061609molecular_functionfructose-1-phosphate aldolase activity
D0061624biological_processfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
D0070061molecular_functionfructose binding
D0070062cellular_componentextracellular exosome
D0070072biological_processvacuolar proton-transporting V-type ATPase complex assembly
D1905856biological_processnegative regulation of pentose-phosphate shunt
Functional Information from PROSITE/UniProt
site_idPS00158
Number of Residues11
DetailsALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VyLEGtLLKPN
ChainResidueDetails
DVAL222-ASN232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00883
ChainResidueDetails
DGLU188
CGLU188
BGLU188
AGLU188

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Schiff-base intermediate with dihydroxyacetone-P => ECO:0000250|UniProtKB:P00883
ChainResidueDetails
DLYS230
CLYS230
BLYS230
ALYS230

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00883
ChainResidueDetails
DARG43
AARG43
ASER272
AARG304
DSER272
DARG304
CARG43
CSER272
CARG304
BARG43
BSER272
BARG304

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate => ECO:0000250|UniProtKB:P00883
ChainResidueDetails
DTYR364
CTYR364
BTYR364
ATYR364

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q91Y97
ChainResidueDetails
DALA2
CALA2
BALA2
AALA2

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q91Y97
ChainResidueDetails
DLYS13
ALYS13
ALYS121
ALYS317
DLYS121
DLYS317
CLYS13
CLYS121
CLYS317
BLYS13
BLYS121
BLYS317

site_idSWS_FT_FI7
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER36
CSER272
CSER276
CSER309
BSER36
BSER89
BSER132
BSER272
BSER276
BSER309
ASER36
DSER89
ASER89
ASER132
ASER272
ASER276
ASER309
DSER132
DSER272
DSER276
DSER309
CSER36
CSER89
CSER132

site_idSWS_FT_FI8
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DTHR39
DTHR119
CTHR39
CTHR119
BTHR39
BTHR119
ATHR39
ATHR119

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00884
ChainResidueDetails
DSER299
DSER301
CSER299
CSER301
BSER299
BSER301
ASER299
ASER301

220113

PDB entries from 2024-05-22

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