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8CT2

Local refinement of AQP1 tetramer (C1; refinement mask included D1 of protein 4.2 and Ankyrin-1 AR1-5) in Class 2 of erythrocyte ankyrin-1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003091biological_processrenal water homeostasis
A0003094biological_processglomerular filtration
A0003097biological_processrenal water transport
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005267molecular_functionpotassium channel activity
A0005372molecular_functionwater transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006813biological_processpotassium ion transport
A0006833biological_processwater transport
A0006884biological_processcell volume homeostasis
A0006972biological_processhyperosmotic response
A0008519molecular_functionammonium transmembrane transporter activity
A0009925cellular_componentbasal plasma membrane
A0009992biological_processintracellular water homeostasis
A0010761biological_processfibroblast migration
A0010763biological_processpositive regulation of fibroblast migration
A0015079molecular_functionpotassium ion transmembrane transporter activity
A0015168molecular_functionglycerol transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0015670biological_processcarbon dioxide transport
A0015793biological_processglycerol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016477biological_processcell migration
A0019233biological_processsensory perception of pain
A0019725biological_processcellular homeostasis
A0019934biological_processcGMP-mediated signaling
A0021670biological_processlateral ventricle development
A0022857molecular_functiontransmembrane transporter activity
A0030157biological_processpancreatic juice secretion
A0030184molecular_functionnitric oxide transmembrane transporter activity
A0030185biological_processnitric oxide transport
A0030424cellular_componentaxon
A0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
A0031526cellular_componentbrush border membrane
A0031965cellular_componentnuclear membrane
A0032940biological_processsecretion by cell
A0033326biological_processcerebrospinal fluid secretion
A0033363biological_processsecretory granule organization
A0034644biological_processcellular response to UV
A0035377biological_processtransepithelial water transport
A0035378biological_processcarbon dioxide transmembrane transport
A0035379molecular_functioncarbon dioxide transmembrane transporter activity
A0042060biological_processwound healing
A0042383cellular_componentsarcolemma
A0042476biological_processodontogenesis
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0044241biological_processlipid digestion
A0045177cellular_componentapical part of cell
A0045766biological_processpositive regulation of angiogenesis
A0046875molecular_functionephrin receptor binding
A0046878biological_processpositive regulation of saliva secretion
A0048146biological_processpositive regulation of fibroblast proliferation
A0048593biological_processcamera-type eye morphogenesis
A0050829biological_processdefense response to Gram-negative bacterium
A0050891biological_processmulticellular organismal-level water homeostasis
A0051458biological_processcorticotropin secretion
A0051649biological_processestablishment of localization in cell
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0070295biological_processrenal water absorption
A0070301biological_processcellular response to hydrogen peroxide
A0071241biological_processcellular response to inorganic substance
A0071260biological_processcellular response to mechanical stimulus
A0071280biological_processcellular response to copper ion
A0071288biological_processcellular response to mercury ion
A0071300biological_processcellular response to retinoic acid
A0071320biological_processcellular response to cAMP
A0071456biological_processcellular response to hypoxia
A0071472biological_processcellular response to salt stress
A0071474biological_processcellular hyperosmotic response
A0071549biological_processcellular response to dexamethasone stimulus
A0071732biological_processcellular response to nitric oxide
A0071805biological_processpotassium ion transmembrane transport
A0072220biological_processmetanephric descending thin limb development
A0072230biological_processmetanephric proximal straight tubule development
A0072232biological_processmetanephric proximal convoluted tubule segment 2 development
A0072239biological_processmetanephric glomerulus vasculature development
A0072488biological_processammonium transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A0170014cellular_componentankyrin-1 complex
B0003091biological_processrenal water homeostasis
B0003094biological_processglomerular filtration
B0003097biological_processrenal water transport
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005267molecular_functionpotassium channel activity
B0005372molecular_functionwater transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006813biological_processpotassium ion transport
B0006833biological_processwater transport
B0006884biological_processcell volume homeostasis
B0006972biological_processhyperosmotic response
B0008519molecular_functionammonium transmembrane transporter activity
B0009925cellular_componentbasal plasma membrane
B0009992biological_processintracellular water homeostasis
B0010761biological_processfibroblast migration
B0010763biological_processpositive regulation of fibroblast migration
B0015079molecular_functionpotassium ion transmembrane transporter activity
B0015168molecular_functionglycerol transmembrane transporter activity
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0015670biological_processcarbon dioxide transport
B0015793biological_processglycerol transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016477biological_processcell migration
B0019233biological_processsensory perception of pain
B0019725biological_processcellular homeostasis
B0019934biological_processcGMP-mediated signaling
B0021670biological_processlateral ventricle development
B0022857molecular_functiontransmembrane transporter activity
B0030157biological_processpancreatic juice secretion
B0030184molecular_functionnitric oxide transmembrane transporter activity
B0030185biological_processnitric oxide transport
B0030424cellular_componentaxon
B0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
B0031526cellular_componentbrush border membrane
B0031965cellular_componentnuclear membrane
B0032940biological_processsecretion by cell
B0033326biological_processcerebrospinal fluid secretion
B0033363biological_processsecretory granule organization
B0034644biological_processcellular response to UV
B0035377biological_processtransepithelial water transport
B0035378biological_processcarbon dioxide transmembrane transport
B0035379molecular_functioncarbon dioxide transmembrane transporter activity
B0042060biological_processwound healing
B0042383cellular_componentsarcolemma
B0042476biological_processodontogenesis
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0044241biological_processlipid digestion
B0045177cellular_componentapical part of cell
B0045766biological_processpositive regulation of angiogenesis
B0046875molecular_functionephrin receptor binding
B0046878biological_processpositive regulation of saliva secretion
B0048146biological_processpositive regulation of fibroblast proliferation
B0048593biological_processcamera-type eye morphogenesis
B0050829biological_processdefense response to Gram-negative bacterium
B0050891biological_processmulticellular organismal-level water homeostasis
B0051458biological_processcorticotropin secretion
B0051649biological_processestablishment of localization in cell
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0070295biological_processrenal water absorption
B0070301biological_processcellular response to hydrogen peroxide
B0071241biological_processcellular response to inorganic substance
B0071260biological_processcellular response to mechanical stimulus
B0071280biological_processcellular response to copper ion
B0071288biological_processcellular response to mercury ion
B0071300biological_processcellular response to retinoic acid
B0071320biological_processcellular response to cAMP
B0071456biological_processcellular response to hypoxia
B0071472biological_processcellular response to salt stress
B0071474biological_processcellular hyperosmotic response
B0071549biological_processcellular response to dexamethasone stimulus
B0071732biological_processcellular response to nitric oxide
B0071805biological_processpotassium ion transmembrane transport
B0072220biological_processmetanephric descending thin limb development
B0072230biological_processmetanephric proximal straight tubule development
B0072232biological_processmetanephric proximal convoluted tubule segment 2 development
B0072239biological_processmetanephric glomerulus vasculature development
B0072488biological_processammonium transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B0170014cellular_componentankyrin-1 complex
C0003091biological_processrenal water homeostasis
C0003094biological_processglomerular filtration
C0003097biological_processrenal water transport
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005267molecular_functionpotassium channel activity
C0005372molecular_functionwater transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0006813biological_processpotassium ion transport
C0006833biological_processwater transport
C0006884biological_processcell volume homeostasis
C0006972biological_processhyperosmotic response
C0008519molecular_functionammonium transmembrane transporter activity
C0009925cellular_componentbasal plasma membrane
C0009992biological_processintracellular water homeostasis
C0010761biological_processfibroblast migration
C0010763biological_processpositive regulation of fibroblast migration
C0015079molecular_functionpotassium ion transmembrane transporter activity
C0015168molecular_functionglycerol transmembrane transporter activity
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0015670biological_processcarbon dioxide transport
C0015793biological_processglycerol transmembrane transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016324cellular_componentapical plasma membrane
C0016477biological_processcell migration
C0019233biological_processsensory perception of pain
C0019725biological_processcellular homeostasis
C0019934biological_processcGMP-mediated signaling
C0021670biological_processlateral ventricle development
C0022857molecular_functiontransmembrane transporter activity
C0030157biological_processpancreatic juice secretion
C0030184molecular_functionnitric oxide transmembrane transporter activity
C0030185biological_processnitric oxide transport
C0030424cellular_componentaxon
C0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
C0031526cellular_componentbrush border membrane
C0031965cellular_componentnuclear membrane
C0032940biological_processsecretion by cell
C0033326biological_processcerebrospinal fluid secretion
C0033363biological_processsecretory granule organization
C0034644biological_processcellular response to UV
C0035377biological_processtransepithelial water transport
C0035378biological_processcarbon dioxide transmembrane transport
C0035379molecular_functioncarbon dioxide transmembrane transporter activity
C0042060biological_processwound healing
C0042383cellular_componentsarcolemma
C0042476biological_processodontogenesis
C0042802molecular_functionidentical protein binding
C0043066biological_processnegative regulation of apoptotic process
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0044241biological_processlipid digestion
C0045177cellular_componentapical part of cell
C0045766biological_processpositive regulation of angiogenesis
C0046875molecular_functionephrin receptor binding
C0046878biological_processpositive regulation of saliva secretion
C0048146biological_processpositive regulation of fibroblast proliferation
C0048593biological_processcamera-type eye morphogenesis
C0050829biological_processdefense response to Gram-negative bacterium
C0050891biological_processmulticellular organismal-level water homeostasis
C0051458biological_processcorticotropin secretion
C0051649biological_processestablishment of localization in cell
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0070295biological_processrenal water absorption
C0070301biological_processcellular response to hydrogen peroxide
C0071241biological_processcellular response to inorganic substance
C0071260biological_processcellular response to mechanical stimulus
C0071280biological_processcellular response to copper ion
C0071288biological_processcellular response to mercury ion
C0071300biological_processcellular response to retinoic acid
C0071320biological_processcellular response to cAMP
C0071456biological_processcellular response to hypoxia
C0071472biological_processcellular response to salt stress
C0071474biological_processcellular hyperosmotic response
C0071549biological_processcellular response to dexamethasone stimulus
C0071732biological_processcellular response to nitric oxide
C0071805biological_processpotassium ion transmembrane transport
C0072220biological_processmetanephric descending thin limb development
C0072230biological_processmetanephric proximal straight tubule development
C0072232biological_processmetanephric proximal convoluted tubule segment 2 development
C0072239biological_processmetanephric glomerulus vasculature development
C0072488biological_processammonium transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C0170014cellular_componentankyrin-1 complex
D0003091biological_processrenal water homeostasis
D0003094biological_processglomerular filtration
D0003097biological_processrenal water transport
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005267molecular_functionpotassium channel activity
D0005372molecular_functionwater transmembrane transporter activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0006813biological_processpotassium ion transport
D0006833biological_processwater transport
D0006884biological_processcell volume homeostasis
D0006972biological_processhyperosmotic response
D0008519molecular_functionammonium transmembrane transporter activity
D0009925cellular_componentbasal plasma membrane
D0009992biological_processintracellular water homeostasis
D0010761biological_processfibroblast migration
D0010763biological_processpositive regulation of fibroblast migration
D0015079molecular_functionpotassium ion transmembrane transporter activity
D0015168molecular_functionglycerol transmembrane transporter activity
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0015670biological_processcarbon dioxide transport
D0015793biological_processglycerol transmembrane transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0016477biological_processcell migration
D0019233biological_processsensory perception of pain
D0019725biological_processcellular homeostasis
D0019934biological_processcGMP-mediated signaling
D0021670biological_processlateral ventricle development
D0022857molecular_functiontransmembrane transporter activity
D0030157biological_processpancreatic juice secretion
D0030184molecular_functionnitric oxide transmembrane transporter activity
D0030185biological_processnitric oxide transport
D0030424cellular_componentaxon
D0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
D0031526cellular_componentbrush border membrane
D0031965cellular_componentnuclear membrane
D0032940biological_processsecretion by cell
D0033326biological_processcerebrospinal fluid secretion
D0033363biological_processsecretory granule organization
D0034644biological_processcellular response to UV
D0035377biological_processtransepithelial water transport
D0035378biological_processcarbon dioxide transmembrane transport
D0035379molecular_functioncarbon dioxide transmembrane transporter activity
D0042060biological_processwound healing
D0042383cellular_componentsarcolemma
D0042476biological_processodontogenesis
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D0044241biological_processlipid digestion
D0045177cellular_componentapical part of cell
D0045766biological_processpositive regulation of angiogenesis
D0046875molecular_functionephrin receptor binding
D0046878biological_processpositive regulation of saliva secretion
D0048146biological_processpositive regulation of fibroblast proliferation
D0048593biological_processcamera-type eye morphogenesis
D0050829biological_processdefense response to Gram-negative bacterium
D0050891biological_processmulticellular organismal-level water homeostasis
D0051458biological_processcorticotropin secretion
D0051649biological_processestablishment of localization in cell
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0070295biological_processrenal water absorption
D0070301biological_processcellular response to hydrogen peroxide
D0071241biological_processcellular response to inorganic substance
D0071260biological_processcellular response to mechanical stimulus
D0071280biological_processcellular response to copper ion
D0071288biological_processcellular response to mercury ion
D0071300biological_processcellular response to retinoic acid
D0071320biological_processcellular response to cAMP
D0071456biological_processcellular response to hypoxia
D0071472biological_processcellular response to salt stress
D0071474biological_processcellular hyperosmotic response
D0071549biological_processcellular response to dexamethasone stimulus
D0071732biological_processcellular response to nitric oxide
D0071805biological_processpotassium ion transmembrane transport
D0072220biological_processmetanephric descending thin limb development
D0072230biological_processmetanephric proximal straight tubule development
D0072232biological_processmetanephric proximal convoluted tubule segment 2 development
D0072239biological_processmetanephric glomerulus vasculature development
D0072488biological_processammonium transmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D0170014cellular_componentankyrin-1 complex
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HLNPAVTLG
ChainResidueDetails
DHIS74-GLY82

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues268
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:7507481
ChainResidueDetails
DALA2-LYS7
BPHE229-LYS269
CALA2-LYS7
CVAL67-ILE70
CLEU85-ALA94
CTHR156-GLY166
CPHE229-LYS269
AALA2-LYS7
AVAL67-ILE70
ALEU85-ALA94
ATHR156-GLY166
DVAL67-ILE70
APHE229-LYS269
DLEU85-ALA94
DTHR156-GLY166
DPHE229-LYS269
BALA2-LYS7
BVAL67-ILE70
BLEU85-ALA94
BTHR156-GLY166

site_idSWS_FT_FI2
Number of Residues112
DetailsTRANSMEM: Helical; Name=Helix 1
ChainResidueDetails
DLYS8-LYS36
BLYS8-LYS36
CLYS8-LYS36
ALYS8-LYS36

site_idSWS_FT_FI3
Number of Residues156
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:7507481
ChainResidueDetails
DTYR37-ASP48
CTHR116-GLY136
CILE184-TYR186
CVAL201-SER207
ATYR37-ASP48
ATHR116-GLY136
AILE184-TYR186
AVAL201-SER207
DTHR116-GLY136
DILE184-TYR186
DVAL201-SER207
BTYR37-ASP48
BTHR116-GLY136
BILE184-TYR186
BVAL201-SER207
CTYR37-ASP48

site_idSWS_FT_FI4
Number of Residues68
DetailsTRANSMEM: Helical; Name=Helix 2
ChainResidueDetails
DASN49-SER66
BASN49-SER66
CASN49-SER66
AASN49-SER66

site_idSWS_FT_FI5
Number of Residues40
DetailsINTRAMEM:
ChainResidueDetails
DSER71-ASN76
DTHR187-ASN192
BSER71-ASN76
BTHR187-ASN192
CSER71-ASN76
CTHR187-ASN192
ASER71-ASN76
ATHR187-ASN192

site_idSWS_FT_FI6
Number of Residues28
DetailsINTRAMEM: Helical; Name=Helix B
ChainResidueDetails
DPRO77-LEU84
BPRO77-LEU84
CPRO77-LEU84
APRO77-LEU84

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Helix 3
ChainResidueDetails
DLEU95-ILE115
BLEU95-ILE115
CLEU95-ILE115
ALEU95-ILE115

site_idSWS_FT_FI8
Number of Residues72
DetailsTRANSMEM: Helical; Name=Helix 4
ChainResidueDetails
DGLN137-ALA155
BGLN137-ALA155
CGLN137-ALA155
AGLN137-ALA155

site_idSWS_FT_FI9
Number of Residues64
DetailsTRANSMEM: Helical; Name=Helix 5
ChainResidueDetails
DSER167-ALA183
BSER167-ALA183
CSER167-ALA183
ASER167-ALA183

site_idSWS_FT_FI10
Number of Residues28
DetailsINTRAMEM: Helical; Name=Helix E
ChainResidueDetails
DPRO193-ALA200
BPRO193-ALA200
CPRO193-ALA200
APRO193-ALA200

site_idSWS_FT_FI11
Number of Residues80
DetailsTRANSMEM: Helical; Name=Helix 6
ChainResidueDetails
DASN208-ASP228
BASN208-ASP228
CASN208-ASP228
AASN208-ASP228

site_idSWS_FT_FI12
Number of Residues12
DetailsSITE: Substrate discrimination
ChainResidueDetails
DPHE56
APHE56
AHIS180
AARG195
DHIS180
DARG195
BPHE56
BHIS180
BARG195
CPHE56
CHIS180
CARG195

site_idSWS_FT_FI13
Number of Residues4
DetailsSITE: Hg(2+)-sensitive residue
ChainResidueDetails
DCYS189
BCYS189
CCYS189
ACYS189

site_idSWS_FT_FI14
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q02013
ChainResidueDetails
DSER247
DSER262
BSER247
BSER262
CSER247
CSER262
ASER247
ASER262

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q02013
ChainResidueDetails
DTYR253
BTYR253
CTYR253
ATYR253

site_idSWS_FT_FI16
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
DASN42
BASN42
CASN42
AASN42

site_idSWS_FT_FI17
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN205
BASN205
CASN205
AASN205

219869

PDB entries from 2024-05-15

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