8C12

Identification of an intermediate activation state of PAK5 reveals a novel mechanism of kinase inhibition.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004672	molecular_function	protein kinase activity
AAA	0004674	molecular_function	protein serine/threonine kinase activity
AAA	0005524	molecular_function	ATP binding
AAA	0006468	biological_process	protein phosphorylation
AAA	0006915	biological_process	apoptotic process
AAA	0007010	biological_process	cytoskeleton organization
BBB	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtekhtgkqv.........AVKK

Chain	Residue	Details
AAA	ILE455-LYS479

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
AAA	ASP568

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
AAA	ILE455
AAA	LYS478

---