Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8B6F

Cryo-EM structure of NADH:ubiquinone oxidoreductase (complex-I) from respiratory supercomplex of Tetrahymena thermophila

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A0	0005543	molecular_function	phospholipid binding
A0	0008915	molecular_function	lipid-A-disaccharide synthase activity
A0	0009245	biological_process	lipid A biosynthetic process
A0	0016757	molecular_function	glycosyltransferase activity
A1	0005739	cellular_component	mitochondrion
A1	0044877	molecular_function	protein-containing complex binding
A1	1901006	biological_process	ubiquinone-6 biosynthetic process
A2	0005739	cellular_component	mitochondrion
A2	0007005	biological_process	mitochondrion organization
A2	0019901	molecular_function	protein kinase binding
A2	0043066	biological_process	negative regulation of apoptotic process
A3	0006631	biological_process	fatty acid metabolic process
A3	0016874	molecular_function	ligase activity
A3	0031956	molecular_function	medium-chain fatty acid-CoA ligase activity
A6	0016020	cellular_component	membrane
A9	0016020	cellular_component	membrane
AA	0003954	molecular_function	NADH dehydrogenase activity
AA	0005739	cellular_component	mitochondrion
AA	0005747	cellular_component	mitochondrial respiratory chain complex I
AA	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AA	0009507	cellular_component	chloroplast
AA	0015990	biological_process	electron transport coupled proton transport
AA	0016020	cellular_component	membrane
AA	0016491	molecular_function	oxidoreductase activity
AA	0042773	biological_process	ATP synthesis coupled electron transport
AB	0003954	molecular_function	NADH dehydrogenase activity
AB	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AB	0016020	cellular_component	membrane
AB	0016491	molecular_function	oxidoreductase activity
AB	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AB	0042773	biological_process	ATP synthesis coupled electron transport
AB	0045333	biological_process	cellular respiration
AB	0051536	molecular_function	iron-sulfur cluster binding
AB	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AB	0055085	biological_process	transmembrane transport
AC	0003954	molecular_function	NADH dehydrogenase activity
AC	0005739	cellular_component	mitochondrion
AC	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AC	0009060	biological_process	aerobic respiration
AC	0015990	biological_process	electron transport coupled proton transport
AC	0016020	cellular_component	membrane
AC	0016491	molecular_function	oxidoreductase activity
AC	0031966	cellular_component	mitochondrial membrane
AC	0042773	biological_process	ATP synthesis coupled electron transport
AC	0048039	molecular_function	ubiquinone binding
AC	0070469	cellular_component	respirasome
AD	0003954	molecular_function	NADH dehydrogenase activity
AD	0005739	cellular_component	mitochondrion
AD	0005743	cellular_component	mitochondrial inner membrane
AD	0005747	cellular_component	mitochondrial respiratory chain complex I
AD	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AD	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AD	0010181	molecular_function	FMN binding
AD	0045271	cellular_component	respiratory chain complex I
AD	0046872	molecular_function	metal ion binding
AD	0051287	molecular_function	NAD binding
AD	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AD	0055085	biological_process	transmembrane transport
AD	0070469	cellular_component	respirasome
AE	0005739	cellular_component	mitochondrion
AE	0005747	cellular_component	mitochondrial respiratory chain complex I
AE	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AE	0009535	cellular_component	chloroplast thylakoid membrane
AE	0016491	molecular_function	oxidoreductase activity
AE	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AE	0048038	molecular_function	quinone binding
AE	0051287	molecular_function	NAD binding
AF	0005739	cellular_component	mitochondrion
AF	0016020	cellular_component	membrane
AH	0003954	molecular_function	NADH dehydrogenase activity
AH	0005739	cellular_component	mitochondrion
AH	0005743	cellular_component	mitochondrial inner membrane
AH	0005747	cellular_component	mitochondrial respiratory chain complex I
AH	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AH	0009060	biological_process	aerobic respiration
AH	0016020	cellular_component	membrane
AH	0016491	molecular_function	oxidoreductase activity
AH	0055085	biological_process	transmembrane transport
AI	0003954	molecular_function	NADH dehydrogenase activity
AI	0005747	cellular_component	mitochondrial respiratory chain complex I
AI	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AI	0016491	molecular_function	oxidoreductase activity
AI	0045271	cellular_component	respiratory chain complex I
AI	0046872	molecular_function	metal ion binding
AI	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AJ	0005739	cellular_component	mitochondrion
AJ	0016020	cellular_component	membrane
AL	0003954	molecular_function	NADH dehydrogenase activity
AL	0005739	cellular_component	mitochondrion
AL	0005747	cellular_component	mitochondrial respiratory chain complex I
AL	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AL	0016020	cellular_component	membrane
AL	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AL	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AN	0005739	cellular_component	mitochondrion
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0005747	cellular_component	mitochondrial respiratory chain complex I
AN	0022904	biological_process	respiratory electron transport chain
AO	0005739	cellular_component	mitochondrion
AO	0005747	cellular_component	mitochondrial respiratory chain complex I
AO	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AO	0016491	molecular_function	oxidoreductase activity
AO	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
AO	0055085	biological_process	transmembrane transport
AP	0005739	cellular_component	mitochondrion
AP	0005743	cellular_component	mitochondrial inner membrane
AP	0005747	cellular_component	mitochondrial respiratory chain complex I
AP	0006979	biological_process	response to oxidative stress
AP	0016020	cellular_component	membrane
AP	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AP	0070469	cellular_component	respirasome
AR	0005739	cellular_component	mitochondrion
AR	0005743	cellular_component	mitochondrial inner membrane
AR	0005747	cellular_component	mitochondrial respiratory chain complex I
AR	0022900	biological_process	electron transport chain
AR	0070469	cellular_component	respirasome
AS	0005739	cellular_component	mitochondrion
AS	0005743	cellular_component	mitochondrial inner membrane
AS	0005747	cellular_component	mitochondrial respiratory chain complex I
AS	0006979	biological_process	response to oxidative stress
AS	0070469	cellular_component	respirasome
AT	0005739	cellular_component	mitochondrion
AT	0005747	cellular_component	mitochondrial respiratory chain complex I
AT	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AT	0009060	biological_process	aerobic respiration
AT	0015990	biological_process	electron transport coupled proton transport
AT	0016491	molecular_function	oxidoreductase activity
AT	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AT	0046872	molecular_function	metal ion binding
AT	0048038	molecular_function	quinone binding
AT	0051536	molecular_function	iron-sulfur cluster binding
AT	0051539	molecular_function	4 iron, 4 sulfur cluster binding
AU	0016020	cellular_component	membrane
AV	0000035	molecular_function	acyl binding
AV	0000036	molecular_function	acyl carrier activity
AV	0005739	cellular_component	mitochondrion
AV	0005747	cellular_component	mitochondrial respiratory chain complex I
AV	0006633	biological_process	fatty acid biosynthetic process
AW	0000035	molecular_function	acyl binding
AW	0000036	molecular_function	acyl carrier activity
AW	0005739	cellular_component	mitochondrion
AW	0005747	cellular_component	mitochondrial respiratory chain complex I
AW	0006633	biological_process	fatty acid biosynthetic process
AX	0005739	cellular_component	mitochondrion
AX	0005747	cellular_component	mitochondrial respiratory chain complex I
AX	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
AX	0009507	cellular_component	chloroplast
AX	0016020	cellular_component	membrane
AX	0016491	molecular_function	oxidoreductase activity
AX	0031966	cellular_component	mitochondrial membrane
AX	0055085	biological_process	transmembrane transport
AX	0070469	cellular_component	respirasome
AY	0005739	cellular_component	mitochondrion
AY	0016020	cellular_component	membrane
AZ	0005739	cellular_component	mitochondrion
AZ	0005743	cellular_component	mitochondrial inner membrane
AZ	0005747	cellular_component	mitochondrial respiratory chain complex I
AZ	0005840	cellular_component	ribosome
AZ	0070469	cellular_component	respirasome
B0	0016020	cellular_component	membrane
B4	0016020	cellular_component	membrane
B5	0016020	cellular_component	membrane
B6	0016020	cellular_component	membrane
BB	0016020	cellular_component	membrane
BD	0016020	cellular_component	membrane
BH	0005739	cellular_component	mitochondrion
BH	0016020	cellular_component	membrane
BH	0016491	molecular_function	oxidoreductase activity
BI	0005829	cellular_component	cytosol
BI	0051536	molecular_function	iron-sulfur cluster binding
BI	0051537	molecular_function	2 iron, 2 sulfur cluster binding
BI	0140647	biological_process	P450-containing electron transport chain
BL	0016020	cellular_component	membrane
BM	0016020	cellular_component	membrane
BR	0005747	cellular_component	mitochondrial respiratory chain complex I
BR	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
BX	0016020	cellular_component	membrane
BY	0005739	cellular_component	mitochondrion
BY	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. NWEy.QYDGQWWSM

Chain	Residue	Details
BT	ASN81-MET93

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
AB	PRO62-CYS79

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
AB	CYS129-GLN141

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

Chain	Residue	Details
AB	ARG176-PHE186

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
AD	GLU378-GLY389

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGsEKLiEdR

Chain	Residue	Details
AE	LEU62-ARG73

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. KLGLDSLDQTALLASI

Chain	Residue	Details
AV	LYS90-ILE105

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCQsACP

Chain	Residue	Details
AL	CYS136-PRO147
AL	CYS175-PRO186

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtsEMYginykwKidtRkLL

Chain	Residue	Details
AO	GLU136-LEU157

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GRLQyIaDALKLFiKG

Chain	Residue	Details
AH	GLY63-GLY78

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEAEseLVt.G

Chain	Residue	Details
AH	PRO218-GLY231

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)