8B0F

CryoEM structure of C5b8-CD59

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006956	biological_process	complement activation
B	0005579	cellular_component	membrane attack complex
B	0006955	biological_process	immune response
C	0005579	cellular_component	membrane attack complex
C	0006955	biological_process	immune response
D	0005579	cellular_component	membrane attack complex
D	0006955	biological_process	immune response
E	0005579	cellular_component	membrane attack complex
E	0006955	biological_process	immune response
F	0005579	cellular_component	membrane attack complex
F	0006956	biological_process	complement activation

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	14
Details	LIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV

Chain	Residue	Details
F	ASN21-VAL34

---

site_id	PS01177
Number of Residues	35
Details	ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGacvnnde.TCEqraarisl.GprCikafte.CC

Chain	Residue	Details
A	CYS698-CYS732

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CvCkmPYecgpsldvC

Chain	Residue	Details
C	CYS713-CYS728

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site_id	PS00983
Number of Residues	44
Details	LY6_UPAR Ly-6 / u-PAR domain signature. QCYnCpnptad..Cktav....NCSsdfdaClitkaglqvynkcwkfeh......C

Chain	Residue	Details
G	GLN2-CYS45

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CqCrlGslGAaC

Chain	Residue	Details
C	CYS475-CYS486
E	CYS487-CYS498
D	CYS469-CYS480
B	CYS541-CYS552

---

site_id	PS00279
Number of Residues	12
Details	MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY

Chain	Residue	Details
C	TYR292-TYR303
E	TYR300-TYR311
D	TYR279-TYR290
B	TYR354-TYR365

---

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CLkrhlv.CNgdqDCldgsDEDd....C

Chain	Residue	Details
C	CYS96-CYS119
E	CYS78-CYS100
D	CYS79-CYS101
B	CYS151-CYS173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	LIPID: GPI-anchor amidated asparagine => ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:8276756

Chain	Residue	Details
G	ASN77

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:8670172

Chain	Residue	Details
G	ASN18
E	TRP512
E	TRP515
E	TRP518
B	TRP574

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:10805801

Chain	Residue	Details
G	LYS41
C	TRP506
C	TRP509

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000305

Chain	Residue	Details
G	THR51
G	THR52

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490

Chain	Residue	Details
C	ASN754

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