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8AMW

AQP7 dimer of tetramers_C1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005811cellular_componentlipid droplet
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005938cellular_componentcell cortex
A0006833biological_processwater transport
A0015204molecular_functionurea transmembrane transporter activity
A0015250molecular_functionwater channel activity
A0015254molecular_functionglycerol channel activity
A0015267molecular_functionchannel activity
A0015791biological_processpolyol transmembrane transport
A0015793biological_processglycerol transmembrane transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0055085biological_processtransmembrane transport
A0071918biological_processurea transmembrane transport
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005811cellular_componentlipid droplet
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005938cellular_componentcell cortex
B0006833biological_processwater transport
B0015204molecular_functionurea transmembrane transporter activity
B0015250molecular_functionwater channel activity
B0015254molecular_functionglycerol channel activity
B0015267molecular_functionchannel activity
B0015791biological_processpolyol transmembrane transport
B0015793biological_processglycerol transmembrane transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0055085biological_processtransmembrane transport
B0071918biological_processurea transmembrane transport
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005811cellular_componentlipid droplet
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005938cellular_componentcell cortex
C0006833biological_processwater transport
C0015204molecular_functionurea transmembrane transporter activity
C0015250molecular_functionwater channel activity
C0015254molecular_functionglycerol channel activity
C0015267molecular_functionchannel activity
C0015791biological_processpolyol transmembrane transport
C0015793biological_processglycerol transmembrane transport
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0055085biological_processtransmembrane transport
C0071918biological_processurea transmembrane transport
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005811cellular_componentlipid droplet
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005938cellular_componentcell cortex
D0006833biological_processwater transport
D0015204molecular_functionurea transmembrane transporter activity
D0015250molecular_functionwater channel activity
D0015254molecular_functionglycerol channel activity
D0015267molecular_functionchannel activity
D0015791biological_processpolyol transmembrane transport
D0015793biological_processglycerol transmembrane transport
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0055085biological_processtransmembrane transport
D0071918biological_processurea transmembrane transport
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005811cellular_componentlipid droplet
E0005886cellular_componentplasma membrane
E0005911cellular_componentcell-cell junction
E0005938cellular_componentcell cortex
E0006833biological_processwater transport
E0015204molecular_functionurea transmembrane transporter activity
E0015250molecular_functionwater channel activity
E0015254molecular_functionglycerol channel activity
E0015267molecular_functionchannel activity
E0015791biological_processpolyol transmembrane transport
E0015793biological_processglycerol transmembrane transport
E0016020cellular_componentmembrane
E0016323cellular_componentbasolateral plasma membrane
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0055085biological_processtransmembrane transport
E0071918biological_processurea transmembrane transport
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005811cellular_componentlipid droplet
F0005886cellular_componentplasma membrane
F0005911cellular_componentcell-cell junction
F0005938cellular_componentcell cortex
F0006833biological_processwater transport
F0015204molecular_functionurea transmembrane transporter activity
F0015250molecular_functionwater channel activity
F0015254molecular_functionglycerol channel activity
F0015267molecular_functionchannel activity
F0015791biological_processpolyol transmembrane transport
F0015793biological_processglycerol transmembrane transport
F0016020cellular_componentmembrane
F0016323cellular_componentbasolateral plasma membrane
F0030659cellular_componentcytoplasmic vesicle membrane
F0031410cellular_componentcytoplasmic vesicle
F0055085biological_processtransmembrane transport
F0071918biological_processurea transmembrane transport
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005811cellular_componentlipid droplet
G0005886cellular_componentplasma membrane
G0005911cellular_componentcell-cell junction
G0005938cellular_componentcell cortex
G0006833biological_processwater transport
G0015204molecular_functionurea transmembrane transporter activity
G0015250molecular_functionwater channel activity
G0015254molecular_functionglycerol channel activity
G0015267molecular_functionchannel activity
G0015791biological_processpolyol transmembrane transport
G0015793biological_processglycerol transmembrane transport
G0016020cellular_componentmembrane
G0016323cellular_componentbasolateral plasma membrane
G0030659cellular_componentcytoplasmic vesicle membrane
G0031410cellular_componentcytoplasmic vesicle
G0055085biological_processtransmembrane transport
G0071918biological_processurea transmembrane transport
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005811cellular_componentlipid droplet
H0005886cellular_componentplasma membrane
H0005911cellular_componentcell-cell junction
H0005938cellular_componentcell cortex
H0006833biological_processwater transport
H0015204molecular_functionurea transmembrane transporter activity
H0015250molecular_functionwater channel activity
H0015254molecular_functionglycerol channel activity
H0015267molecular_functionchannel activity
H0015791biological_processpolyol transmembrane transport
H0015793biological_processglycerol transmembrane transport
H0016020cellular_componentmembrane
H0016323cellular_componentbasolateral plasma membrane
H0030659cellular_componentcytoplasmic vesicle membrane
H0031410cellular_componentcytoplasmic vesicle
H0055085biological_processtransmembrane transport
H0071918biological_processurea transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues464
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-ARG35
AARG87-GLY90
APHE99-PHE112
AILE189-ALA197
BMET1-ARG35
BARG87-GLY90
BPHE99-PHE112
BILE189-ALA197
CMET1-ARG35
CARG87-GLY90
CPHE99-PHE112
CILE189-ALA197
DMET1-ARG35
DARG87-GLY90
DPHE99-PHE112
DILE189-ALA197
EMET1-ARG35
EARG87-GLY90
EPHE99-PHE112
EILE189-ALA197
FMET1-ARG35
FARG87-GLY90
FPHE99-PHE112
FILE189-ALA197
GMET1-ARG35
GARG87-GLY90
GPHE99-PHE112
GILE189-ALA197
HMET1-ARG35
HARG87-GLY90
HPHE99-PHE112
HILE189-ALA197

site_idSWS_FT_FI2
Number of Residues920
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:P55087
ChainResidueDetails
AGLU36-ALA56
ATYR67-GLY86
APRO113-VAL148
ALEU168-ALA188
ALEU198-MET219
BGLU36-ALA56
BTYR67-GLY86
BPRO113-VAL148
BLEU168-ALA188
BLEU198-MET219
CGLU36-ALA56
CTYR67-GLY86
CPRO113-VAL148
CLEU168-ALA188
CLEU198-MET219
DGLU36-ALA56
DTYR67-GLY86
DPRO113-VAL148
DLEU168-ALA188
DLEU198-MET219
EGLU36-ALA56
ETYR67-GLY86
EPRO113-VAL148
ELEU168-ALA188
ELEU198-MET219
FGLU36-ALA56
FTYR67-GLY86
FPRO113-VAL148
FLEU168-ALA188
FLEU198-MET219
GGLU36-ALA56
GTYR67-GLY86
GPRO113-VAL148
GLEU168-ALA188
GLEU198-MET219
HGLU36-ALA56
HTYR67-GLY86
HPRO113-VAL148
HLEU168-ALA188
HLEU198-MET219

site_idSWS_FT_FI3
Number of Residues1072
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AHIS57-SER66
ATHR149-THR167
AASN220-THR221
APHE236-PHE342
BHIS57-SER66
BTHR149-THR167
BASN220-THR221
BPHE236-PHE342
CHIS57-SER66
CTHR149-THR167
CASN220-THR221
CPHE236-PHE342
DHIS57-SER66
DTHR149-THR167
DASN220-THR221
DPHE236-PHE342
EHIS57-SER66
ETHR149-THR167
EASN220-THR221
EPHE236-PHE342
FHIS57-SER66
FTHR149-THR167
FASN220-THR221
FPHE236-PHE342
GHIS57-SER66
GTHR149-THR167
GASN220-THR221
GPHE236-PHE342
HHIS57-SER66
HTHR149-THR167
HASN220-THR221
HPHE236-PHE342

site_idSWS_FT_FI4
Number of Residues160
DetailsINTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:P55087
ChainResidueDetails
AALA91-THR98
AGLY222-ILE235
BALA91-THR98
BGLY222-ILE235
CALA91-THR98
CGLY222-ILE235
DALA91-THR98
DGLY222-ILE235
EALA91-THR98
EGLY222-ILE235
FALA91-THR98
FGLY222-ILE235
GALA91-THR98
GGLY222-ILE235
HALA91-THR98
HGLY222-ILE235

site_idSWS_FT_FI5
Number of Residues8
DetailsSITE: Important for permeability to glycerol => ECO:0000269|PubMed:30423801
ChainResidueDetails
ATYR135
BTYR135
CTYR135
DTYR135
ETYR135
FTYR135
GTYR135
HTYR135

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P56403
ChainResidueDetails
ASER20
BSER20
CSER20
DSER20
ESER20
FSER20
GSER20
HSER20

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PDB entries from 2024-05-15

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