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8AG6

human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0000400molecular_functionfour-way junction DNA binding
A0000781cellular_componentchromosome, telomeric region
A0001701biological_processin utero embryonic development
A0002204biological_processsomatic recombination of immunoglobulin genes involved in immune response
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003684molecular_functiondamaged DNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0006119biological_processoxidative phosphorylation
A0006281biological_processDNA repair
A0006298biological_processmismatch repair
A0006301biological_processpostreplication repair
A0006302biological_processdouble-strand break repair
A0006312biological_processmitotic recombination
A0006974biological_processDNA damage response
A0007281biological_processgerm cell development
A0008094molecular_functionATP-dependent activity, acting on DNA
A0008340biological_processdetermination of adult lifespan
A0008584biological_processmale gonad development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010165biological_processresponse to X-ray
A0010224biological_processresponse to UV-B
A0016020cellular_componentmembrane
A0016446biological_processsomatic hypermutation of immunoglobulin genes
A0016447biological_processsomatic recombination of immunoglobulin gene segments
A0016887molecular_functionATP hydrolysis activity
A0019237molecular_functioncentromeric DNA binding
A0019724biological_processB cell mediated immunity
A0030183biological_processB cell differentiation
A0030983molecular_functionmismatched DNA binding
A0031573biological_processmitotic intra-S DNA damage checkpoint signaling
A0032137molecular_functionguanine/thymine mispair binding
A0032139molecular_functiondinucleotide insertion or deletion binding
A0032142molecular_functionsingle guanine insertion binding
A0032143molecular_functionsingle thymine insertion binding
A0032181molecular_functiondinucleotide repeat insertion binding
A0032301cellular_componentMutSalpha complex
A0032302cellular_componentMutSbeta complex
A0032357molecular_functionoxidized purine DNA binding
A0032405molecular_functionMutLalpha complex binding
A0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0042803molecular_functionprotein homodimerization activity
A0043524biological_processnegative regulation of neuron apoptotic process
A0043531molecular_functionADP binding
A0043570biological_processmaintenance of DNA repeat elements
A0045190biological_processisotype switching
A0045910biological_processnegative regulation of DNA recombination
A0048298biological_processpositive regulation of isotype switching to IgA isotypes
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0051096biological_processpositive regulation of helicase activity
A0051726biological_processregulation of cell cycle
A0071168biological_processprotein localization to chromatin
A0140664molecular_functionATP-dependent DNA damage sensor activity
B0000287molecular_functionmagnesium ion binding
B0000400molecular_functionfour-way junction DNA binding
B0000710biological_processmeiotic mismatch repair
B0000785cellular_componentchromatin
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006298biological_processmismatch repair
B0006974biological_processDNA damage response
B0007283biological_processspermatogenesis
B0008094molecular_functionATP-dependent activity, acting on DNA
B0008340biological_processdetermination of adult lifespan
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0009411biological_processresponse to UV
B0016446biological_processsomatic hypermutation of immunoglobulin genes
B0016447biological_processsomatic recombination of immunoglobulin gene segments
B0019899molecular_functionenzyme binding
B0030983molecular_functionmismatched DNA binding
B0032137molecular_functionguanine/thymine mispair binding
B0032142molecular_functionsingle guanine insertion binding
B0032143molecular_functionsingle thymine insertion binding
B0032301cellular_componentMutSalpha complex
B0032357molecular_functionoxidized purine DNA binding
B0032405molecular_functionMutLalpha complex binding
B0035064molecular_functionmethylated histone binding
B0042803molecular_functionprotein homodimerization activity
B0043231cellular_componentintracellular membrane-bounded organelle
B0043531molecular_functionADP binding
B0043570biological_processmaintenance of DNA repeat elements
B0045190biological_processisotype switching
B0045910biological_processnegative regulation of DNA recombination
B0051096biological_processpositive regulation of helicase activity
B0097193biological_processintrinsic apoptotic signaling pathway
B0140664molecular_functionATP-dependent DNA damage sensor activity
Functional Information from PROSITE/UniProt
site_idPS00486
Number of Residues17
DetailsDNA_MISMATCH_REPAIR_2 DNA mismatch repair proteins mutS family signature. SLvLvDELGRGTatfdG
ChainResidueDetails
ASER743-GLY759
BSER1208-GLY1224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255
ChainResidueDetails
BGLY1134

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER14

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243
ChainResidueDetails
BSER41
BSER43

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS70
BLYS504

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER79
BSER91
BSER200
BSER254
BSER256

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER137

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER219

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER227

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER252

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER261

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692
ChainResidueDetails
BTHR269

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
BSER274
BSER275
BSER279
BSER280

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER309

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR488
BTHR1010

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER830

site_idSWS_FT_FI16
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER935

219869

PDB entries from 2024-05-15

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