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7Z14

Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain neurotoxin.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007165biological_processsignal transduction
A0007268biological_processchemical synaptic transmission
A0016020cellular_componentmembrane
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0050877biological_processnervous system process
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007165biological_processsignal transduction
B0007268biological_processchemical synaptic transmission
B0016020cellular_componentmembrane
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0043005cellular_componentneuron projection
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0050877biological_processnervous system process
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007165biological_processsignal transduction
C0007268biological_processchemical synaptic transmission
C0016020cellular_componentmembrane
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0050877biological_processnervous system process
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0007165biological_processsignal transduction
D0007268biological_processchemical synaptic transmission
D0016020cellular_componentmembrane
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0050877biological_processnervous system process
D0060078biological_processregulation of postsynaptic membrane potential
D0060079biological_processexcitatory postsynaptic potential
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0007165biological_processsignal transduction
E0007268biological_processchemical synaptic transmission
E0016020cellular_componentmembrane
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0034220biological_processmonoatomic ion transmembrane transport
E0042391biological_processregulation of membrane potential
E0043005cellular_componentneuron projection
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0050877biological_processnervous system process
E0060078biological_processregulation of postsynaptic membrane potential
E0060079biological_processexcitatory postsynaptic potential
E1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
F0005576cellular_componentextracellular region
F0090729molecular_functiontoxin activity
G0005576cellular_componentextracellular region
G0090729molecular_functiontoxin activity
Functional Information from PROSITE/UniProt
site_idPS00272
Number of Residues19
DetailsSNAKE_TOXIN Snake toxins signature. GCg..CPkvkpgiklh.CCrtD
ChainResidueDetails
FGLY38-ASP56

site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpIaVtyFPfDwqnC
ChainResidueDetails
BCYS128-CYS142
ECYS128-CYS142
CCYS130-CYS144
ACYS128-CYS142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues217
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
EGLU1-LYS218
DSER1-ILE210

site_idSWS_FT_FI2
Number of Residues86
DetailsTRANSMEM: Helical
ChainResidueDetails
EPRO219-LEU243
ECYS252-ALA270
ETYR286-VAL307
EALA450-ASN473
DPRO211-LEU235
DMET243-VAL261
DTYR277-ILE296
DILE409-ALA427

site_idSWS_FT_FI3
Number of Residues141
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
ESER308-LYS449
DASN297-HIS408

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:1721053
ChainResidueDetails
ETYR364
DASN141

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN68
CASN208

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2742850
ChainResidueDetails
CASN143

219869

PDB entries from 2024-05-15

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