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7YWX

Structure of the human CCAN CENP-A alpha-satellite complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000132biological_processestablishment of mitotic spindle orientation
A0000281biological_processmitotic cytokinesis
A0000775cellular_componentchromosome, centromeric region
A0000779cellular_componentcondensed chromosome, centromeric region
A0000786cellular_componentnucleosome
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005721cellular_componentpericentric heterochromatin
A0005829cellular_componentcytosol
A0030527molecular_functionstructural constituent of chromatin
A0034080biological_processCENP-A containing chromatin assembly
A0043229cellular_componentintracellular organelle
A0043505cellular_componentCENP-A containing nucleosome
A0046982molecular_functionprotein heterodimerization activity
A0051301biological_processcell division
A0051382biological_processkinetochore assembly
A0061638cellular_componentCENP-A containing chromatin
A0061644biological_processprotein localization to CENP-A containing chromatin
A0071459biological_processprotein localization to chromosome, centromeric region
B0000781cellular_componentchromosome, telomeric region
B0000786cellular_componentnucleosome
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0016020cellular_componentmembrane
B0030527molecular_functionstructural constituent of chromatin
B0032200biological_processtelomere organization
B0032991cellular_componentprotein-containing complex
B0043505cellular_componentCENP-A containing nucleosome
B0045653biological_processnegative regulation of megakaryocyte differentiation
B0046982molecular_functionprotein heterodimerization activity
B0061644biological_processprotein localization to CENP-A containing chromatin
B0070062cellular_componentextracellular exosome
C0000786cellular_componentnucleosome
C0003674molecular_functionmolecular_function
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0008285biological_processnegative regulation of cell population proliferation
C0030527molecular_functionstructural constituent of chromatin
C0031492molecular_functionnucleosomal DNA binding
C0031507biological_processheterochromatin formation
C0043229cellular_componentintracellular organelle
C0046982molecular_functionprotein heterodimerization activity
C0070062cellular_componentextracellular exosome
D0000786cellular_componentnucleosome
D0002227biological_processinnate immune response in mucosa
D0003677molecular_functionDNA binding
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005829cellular_componentcytosol
D0006334biological_processnucleosome assembly
D0019731biological_processantibacterial humoral response
D0030527molecular_functionstructural constituent of chromatin
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0043229cellular_componentintracellular organelle
D0046982molecular_functionprotein heterodimerization activity
D0050830biological_processdefense response to Gram-positive bacterium
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0070062cellular_componentextracellular exosome
E0000132biological_processestablishment of mitotic spindle orientation
E0000281biological_processmitotic cytokinesis
E0000775cellular_componentchromosome, centromeric region
E0000779cellular_componentcondensed chromosome, centromeric region
E0000786cellular_componentnucleosome
E0003677molecular_functionDNA binding
E0003682molecular_functionchromatin binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005721cellular_componentpericentric heterochromatin
E0005829cellular_componentcytosol
E0030527molecular_functionstructural constituent of chromatin
E0034080biological_processCENP-A containing chromatin assembly
E0043229cellular_componentintracellular organelle
E0043505cellular_componentCENP-A containing nucleosome
E0046982molecular_functionprotein heterodimerization activity
E0051301biological_processcell division
E0051382biological_processkinetochore assembly
E0061638cellular_componentCENP-A containing chromatin
E0061644biological_processprotein localization to CENP-A containing chromatin
E0071459biological_processprotein localization to chromosome, centromeric region
F0000781cellular_componentchromosome, telomeric region
F0000786cellular_componentnucleosome
F0003677molecular_functionDNA binding
F0003723molecular_functionRNA binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0006325biological_processchromatin organization
F0006334biological_processnucleosome assembly
F0016020cellular_componentmembrane
F0030527molecular_functionstructural constituent of chromatin
F0032200biological_processtelomere organization
F0032991cellular_componentprotein-containing complex
F0043505cellular_componentCENP-A containing nucleosome
F0045653biological_processnegative regulation of megakaryocyte differentiation
F0046982molecular_functionprotein heterodimerization activity
F0061644biological_processprotein localization to CENP-A containing chromatin
F0070062cellular_componentextracellular exosome
G0000786cellular_componentnucleosome
G0003674molecular_functionmolecular_function
G0003677molecular_functionDNA binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005694cellular_componentchromosome
G0008285biological_processnegative regulation of cell population proliferation
G0030527molecular_functionstructural constituent of chromatin
G0031492molecular_functionnucleosomal DNA binding
G0031507biological_processheterochromatin formation
G0043229cellular_componentintracellular organelle
G0046982molecular_functionprotein heterodimerization activity
G0070062cellular_componentextracellular exosome
H0000775cellular_componentchromosome, centromeric region
H0000776cellular_componentkinetochore
H0000939cellular_componentinner kinetochore
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005694cellular_componentchromosome
H0005730cellular_componentnucleolus
H0005829cellular_componentcytosol
H0007052biological_processmitotic spindle organization
H0007059biological_processchromosome segregation
H0043515molecular_functionkinetochore binding
H0051382biological_processkinetochore assembly
H0051383biological_processkinetochore organization
I0000070biological_processmitotic sister chromatid segregation
I0000775cellular_componentchromosome, centromeric region
I0000776cellular_componentkinetochore
I0000939cellular_componentinner kinetochore
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005694cellular_componentchromosome
I0005829cellular_componentcytosol
I0007059biological_processchromosome segregation
I0007548biological_processsex differentiation
I0016604cellular_componentnuclear body
I0034080biological_processCENP-A containing chromatin assembly
I0034508biological_processcentromere complex assembly
K0000070biological_processmitotic sister chromatid segregation
K0000775cellular_componentchromosome, centromeric region
K0000776cellular_componentkinetochore
K0000939cellular_componentinner kinetochore
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005694cellular_componentchromosome
K0005829cellular_componentcytosol
K0007059biological_processchromosome segregation
K0051382biological_processkinetochore assembly
L0000775cellular_componentchromosome, centromeric region
L0000939cellular_componentinner kinetochore
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005694cellular_componentchromosome
L0005829cellular_componentcytosol
L0007059biological_processchromosome segregation
M0000775cellular_componentchromosome, centromeric region
M0000776cellular_componentkinetochore
M0000939cellular_componentinner kinetochore
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005694cellular_componentchromosome
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0007059biological_processchromosome segregation
N0000775cellular_componentchromosome, centromeric region
N0000776cellular_componentkinetochore
N0000939cellular_componentinner kinetochore
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005694cellular_componentchromosome
N0005829cellular_componentcytosol
N0007059biological_processchromosome segregation
N0034080biological_processCENP-A containing chromatin assembly
O0000775cellular_componentchromosome, centromeric region
O0000776cellular_componentkinetochore
O0000939cellular_componentinner kinetochore
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005694cellular_componentchromosome
O0005829cellular_componentcytosol
O0007059biological_processchromosome segregation
O0016604cellular_componentnuclear body
O0031511cellular_componentMis6-Sim4 complex
O0034508biological_processcentromere complex assembly
P0000775cellular_componentchromosome, centromeric region
P0000939cellular_componentinner kinetochore
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005694cellular_componentchromosome
P0005730cellular_componentnucleolus
P0005829cellular_componentcytosol
P0007059biological_processchromosome segregation
P0034080biological_processCENP-A containing chromatin assembly
Q0000775cellular_componentchromosome, centromeric region
Q0000939cellular_componentinner kinetochore
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005694cellular_componentchromosome
Q0005829cellular_componentcytosol
Q0007059biological_processchromosome segregation
Q0015629cellular_componentactin cytoskeleton
Q0051310biological_processmetaphase chromosome alignment
Q1905342biological_processpositive regulation of protein localization to kinetochore
R0000775cellular_componentchromosome, centromeric region
R0000776cellular_componentkinetochore
R0000939cellular_componentinner kinetochore
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005694cellular_componentchromosome
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006355biological_processregulation of DNA-templated transcription
R0006915biological_processapoptotic process
R0007059biological_processchromosome segregation
R0007155biological_processcell adhesion
R0007165biological_processsignal transduction
R0016020cellular_componentmembrane
R0034080biological_processCENP-A containing chromatin assembly
R0050679biological_processpositive regulation of epithelial cell proliferation
R0051301biological_processcell division
R1904036biological_processnegative regulation of epithelial cell apoptotic process
S0000712biological_processresolution of meiotic recombination intermediates
S0000775cellular_componentchromosome, centromeric region
S0000776cellular_componentkinetochore
S0000785cellular_componentchromatin
S0000939cellular_componentinner kinetochore
S0003677molecular_functionDNA binding
S0003682molecular_functionchromatin binding
S0003690molecular_functiondouble-stranded DNA binding
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005694cellular_componentchromosome
S0005829cellular_componentcytosol
S0006281biological_processDNA repair
S0006974biological_processDNA damage response
S0007059biological_processchromosome segregation
S0031297biological_processreplication fork processing
S0031398biological_processpositive regulation of protein ubiquitination
S0036297biological_processinterstrand cross-link repair
S0043240cellular_componentFanconi anaemia nuclear complex
S0046982molecular_functionprotein heterodimerization activity
S0051301biological_processcell division
S0071821cellular_componentFANCM-MHF complex
T0000278biological_processmitotic cell cycle
T0000775cellular_componentchromosome, centromeric region
T0000776cellular_componentkinetochore
T0000939cellular_componentinner kinetochore
T0003677molecular_functionDNA binding
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005694cellular_componentchromosome
T0005829cellular_componentcytosol
T0007059biological_processchromosome segregation
T0016604cellular_componentnuclear body
T0046982molecular_functionprotein heterodimerization activity
T0051276biological_processchromosome organization
T0051301biological_processcell division
T0051382biological_processkinetochore assembly
U0000775cellular_componentchromosome, centromeric region
U0000776cellular_componentkinetochore
U0000939cellular_componentinner kinetochore
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005694cellular_componentchromosome
U0005737cellular_componentcytoplasm
U0005829cellular_componentcytosol
U0007059biological_processchromosome segregation
U0034451cellular_componentcentriolar satellite
U0043009biological_processchordate embryonic development
V0000786cellular_componentnucleosome
V0002227biological_processinnate immune response in mucosa
V0003677molecular_functionDNA binding
V0005515molecular_functionprotein binding
V0005615cellular_componentextracellular space
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005694cellular_componentchromosome
V0005829cellular_componentcytosol
V0006334biological_processnucleosome assembly
V0019731biological_processantibacterial humoral response
V0030527molecular_functionstructural constituent of chromatin
V0042742biological_processdefense response to bacterium
V0042802molecular_functionidentical protein binding
V0043229cellular_componentintracellular organelle
V0046982molecular_functionprotein heterodimerization activity
V0050830biological_processdefense response to Gram-positive bacterium
V0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
V0070062cellular_componentextracellular exosome
W0000278biological_processmitotic cell cycle
W0000775cellular_componentchromosome, centromeric region
W0000776cellular_componentkinetochore
W0000939cellular_componentinner kinetochore
W0003677molecular_functionDNA binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005694cellular_componentchromosome
W0005730cellular_componentnucleolus
W0007059biological_processchromosome segregation
W0016363cellular_componentnuclear matrix
W0034080biological_processCENP-A containing chromatin assembly
W0046982molecular_functionprotein heterodimerization activity
W0051276biological_processchromosome organization
W0051301biological_processcell division
W0051382biological_processkinetochore assembly
X0000712biological_processresolution of meiotic recombination intermediates
X0000775cellular_componentchromosome, centromeric region
X0000776cellular_componentkinetochore
X0000785cellular_componentchromatin
X0000939cellular_componentinner kinetochore
X0003677molecular_functionDNA binding
X0003690molecular_functiondouble-stranded DNA binding
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005694cellular_componentchromosome
X0005829cellular_componentcytosol
X0006281biological_processDNA repair
X0007059biological_processchromosome segregation
X0031297biological_processreplication fork processing
X0031398biological_processpositive regulation of protein ubiquitination
X0036297biological_processinterstrand cross-link repair
X0043240cellular_componentFanconi anaemia nuclear complex
X0051301biological_processcell division
X0051382biological_processkinetochore assembly
X0071821cellular_componentFANCM-MHF complex
a0000776cellular_componentkinetochore
a0019237molecular_functioncentromeric DNA binding
a0051382biological_processkinetochore assembly
b0000776cellular_componentkinetochore
b0019237molecular_functioncentromeric DNA binding
b0051382biological_processkinetochore assembly
Functional Information from PROSITE/UniProt
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
DARG92-GLY114

site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFsRLAREI
ChainResidueDetails
APRO66-ILE74

site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
BGLY-72-HIS-68

site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
CALA21-VAL27

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
aSER333
aSER528
bSER73
bSER333
bSER528
aSER73

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
bSER96
aSER96

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
DLYS20
DLYS23
DLYS43
DLYS85
VLYS5
VLYS11
VLYS15
VLYS16
VLYS20
VLYS23
VLYS43
VLYS85
DLYS15
DLYS16
aTHR130
bTHR130

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
bSER146
aSER189
bSER189
aSER146

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332
ChainResidueDetails
bTHR183
BLYS-42
FLYS8
FLYS16
FLYS44
aTHR183

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
BLYS5
FLYS12
FLYS31
FLYS77
FLYS91
aSER225
bSER225
BLYS-9

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
bSER261
GLYS74
GLYS75
aSER261

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
VLYS116
VLYS120
DLYS120
VLYS34
aSER316
bSER316

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49452
ChainResidueDetails
aSER397
bSER376
bSER397
GLYS119
GLYS125
aSER376

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
bSER439
aSER439

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
aSER538
bSER538
VLYS46
VLYS108

site_idSWS_FT_FI12
Number of Residues26
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
aLYS45
VLYS57
aLYS134
aLYS119
aLYS180
aLYS212
aLYS238
aLYS260
aLYS271
aLYS273
aLYS297
aLYS440
aLYS534
bLYS45
bLYS119
bLYS134
bLYS180
bLYS212
bLYS238
bLYS260
bLYS271
bLYS273
bLYS297
bLYS440
bLYS534

site_idSWS_FT_FI13
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297
ChainResidueDetails
aLYS217
bLYS217

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08
ChainResidueDetails
VARG86
VARG92
DARG86
DARG92

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729
ChainResidueDetails
DTHR115
VTHR115
FLYS91

site_idSWS_FT_FI16
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:22121020
ChainResidueDetails
DSER112
VSER112
BLYS-7
FLYS20
FLYS59
FLYS79

site_idSWS_FT_FI17
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876
ChainResidueDetails
DLYS5
VLYS5

site_idSWS_FT_FI18
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:22121020
ChainResidueDetails
DLYS120
VLYS120

site_idSWS_FT_FI19
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6
ChainResidueDetails
DLYS20
VLYS20

site_idSWS_FT_FI20
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816
ChainResidueDetails
DLYS34
VLYS34

219869

PDB entries from 2024-05-15

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